Archive for October, 2012

Omega3 with levels 80% + active ingredients EPA/DHA show that healthy young adults can improve their working memory by omega3 supplementation

Wednesday, October 31st, 2012

In the first study of its kind, researchers at the University of Pittsburgh have determined that healthy young adults ages 18-25 can improve their working memory even further by increasing their Omega-3 fatty acid intake. Their findings have been published online in PLOS One.

“Before seeing this data, I would have said it was impossible to move young healthy individuals above their cognitive best,” said Bita Moghaddam, project investigator and professor of neuroscience. “We found that members of this population can enhance their working memory performance even further, despite their already being at the top of their cognitive game.”

Led by Rajesh Narendarn, project principal investigator and associate professor of radiology, the Pitt research team sought healthy young men and women from all ethnicities to boost their Omega-3 intake with supplements for six months. They were monitored monthly through phone calls and outpatient procedures.

Before they began taking the supplements, all participants underwent positron emission tomography (PET) imaging, and their blood samples were analyzed. They were then asked to perform a working memory test in which they were shown a series of letters and numbers. The young adults had to keep track of what appeared one, two, and three times prior, known as a simple “n-back test.”

“What was particularly interesting about the presupplementation n-back test was that it correlated positively with plasma Omega-3,” said Moghaddam. “This means that the Omega-3s they were getting from their diet already positively correlated with their working memory.”

After six months of taking a clinical grade Omega-3 supplement > 80% in active ingredients approved by the Food and Drug Administration—the participants were asked to complete this series of outpatient procedures again. It was during this last stage, during the working memory test and blood sampling, that the improved working memory of this population was revealed.

“So many of the previous studies have been done with the elderly or people with medical conditions, leaving this unique population of young adults unaddressed,” said Matthew Muldoon, project coinvestigator and associate professor of medicine at Pitt. “But what about our highest-functioning periods? Can we help the brain achieve its full potential by adapting our healthy behaviors in our young adult life? We found that we absolutely can.”

Although the effects of Omega-3s on young people were a focus, the Pitt team was also hoping to determine the brain mechanism associated with Omega-3 regulation. Previous rodent studies suggested that removing Omega-3 from the diet might reduce dopamine storage (the neurotransmitter associated with mood as well as working memory) and decrease density in the striatal vesicular monoamine transporter type 2 (commonly referred to as VMAT2, a protein associated with decision making). Therefore, the Pitt researchers posited that increasing VMAT2 protein was the mechanism of action that boosted cognitive performance. Unfortunately, PET imaging revealed this was not the case.

“It is really interesting that diets enriched with Omega-3 fatty acid can enhance cognition in highly functional young individuals,” said Narendarn. “Nevertheless, it was a bit disappointing that our imaging studies were unable to clarify the mechanisms by which it enhances working memory.”

Ongoing animal modeling studies in the Moghaddam lab indicate that brain mechanisms that are affected by Omega-3s may be differently influenced in adolescents and young adults than they are in older adults. With this in mind, the Pitt team will continue to evaluate the effect of Omega-3 fatty acids in this younger population to find the mechanism that improves cognition.

Other Pitt researchers involved in the project include William G. Frankle, professor of psychiatry, and Neal S. Mason, research assistant professor of radiology.

The paper, “Improved Working Memory but No Effect on Striatal Vesicular Monoamine Transporter Type 2 after Omega-3 Polyunsaturated Fatty Acid Supplementation” was published online Oct. 3 by PLOS One and supported by grants from the National Institute on Drug Abuse and the American Reinvestment and Recovery Act of 2009.

Intake of Omega3 is essential for prolonging female reproductive lifespan and improved egg quality.

Sunday, October 14th, 2012

Omega-3 FA for Prolonging Female Reproductive Lifespan

Nehra D, Le HD, Fallon EM, et al. Prolonging the Female Reproductive Lifespan and Improving Egg Quality with Dietary Omega-3 Fatty Acids. Aging Cell. 2012 Sep 15.

Women approaching advanced maternal age have extremely poor outcomes with both natural and assisted fertility. Moreover, the incidence of chromosomal abnormalities and birth defects increases with age. As of yet, there is no effective and practical strategy for delaying ovarian aging or improving oocyte quality.

We demonstrate that the lifelong consumption of a diet rich in omega-3 fatty acids prolongs murine reproductive function into advanced maternal age, while a diet rich in omega-6 fatty acids is associated with very poor reproductive success at advanced maternal age.

Furthermore, even short-term dietary treatment with a diet rich in omega-3 fatty acids initiated at the time of the normal age-related rapid decline in murine reproductive function is associated with improved oocyte quality, while short-term dietary treatment with omega-6 fatty acids results in very poor oocyte quality.

Thus, omega-3 fatty acids may provide an effective and practical avenue for delaying ovarian aging and improving oocyte quality at advanced maternal age.

Research shows effectiveness of a daily dose 2.5G omega3 re treatment of depression in elderly

Sunday, October 14th, 2012

Abstract Nutrition Journal 2012, 11:82 doi:10.1186/1475-2891-11-82
Depression is one of the most frequently missed diagnoses in elderly people, with obvious
negative effects on quality of life. Various studies have shown that long chain omega-3
polyunsaturated fatty acids (n-3 PUFA) may be useful in its management. Our objective was
to evaluate whether a supplement containing n-3 PUFA improves depressive symptoms in
depressed elderly patients, and whether the blood fatty acid pattern is correlated with these
The severity of depressive symptoms according to the Geriatric Depression Scale (GDS),
blood fatty acid composition and erythrocyte phospholipids were analyzed in 46 depressed
females aged 66-95y, diagnosed with depression according to DSMIV, within the context of
a randomized, double-blind, placebo-controlled trial. 22 depressed females were included in
the intervention group (2.5 g/day of n-3 PUFA for 8 weeks), and 24 in the placebo group. We
also measured immunological parameters (CD2, CD3, CD4, CD8, CD16, CD19 and
cytokines (IL-5, IL-15).
The mean GDS score and AA/EPA ratio, in whole blood and RBC membrane phospholipids,
were significantly lower after 2 months supplementation with n-3 PUFA. A significant
correlation between the amelioration of GDS and the AA/EPA ratio with some
immunological parameters, such as CD2, CD19, CD4, CD16 and the ratio CD4/CD8, was
also found. Nevertheless, omega-3 supplementation did not significantly improve the studied
immunological functions.
n-3 PUFA supplementation ameliorates symptoms in elderly depression. The n-3 PUFA
status may be monitored by means of the determination of whole blood AA/EPA ratio.

Research has show than 2G of EPA is required to treat Anxiety

Wednesday, October 10th, 2012

To get the daily intake level of 2 grams of EPA per day that was used in successful trials of using omega-3 fatty acid EPA to reduce anxiety, then this would translate into consuming 14 pounds of cod per day or if you were using salmon which has higher levels of fatty acids salmon then you would require 2 pounds per day to get 2 grams of EPA.
Buydens-Branchey L, Branchey M, and Hibbeln JR. “Associations between increases in plasma n-3 polyunsaturated fatty acids following supplementation and decreases in anger and anxiety in substance abusers.” Prog Neuropsychopharmacol Biol Psychiatry 32:568-575 (2008)

ADHD reduced by 60% by increasing intake of omega3 during pregnancy .

Wednesday, October 10th, 2012

A recent study has shown that pregnant women should eat fish at least twice per week to increase their intake of omega3 and reduce risk of child developing ADHD .
The amount of fish/ omega3 intake a woman consums whilst pregnant may affect her child’s chances of developing attention-deficit/hyperactivity disorder (ADHD).
Eating fish twice a week to increase levels of omega3 was linked to about a 60 per cent lower risk of a child developing certain ADHD-like symptoms, according to research from the Boston University School of Public Health. An area of real concern were the levels of mercury found in larger fish at the top of the food chain such as Tuna , Sword fish .
Elevated mercury levels, which can occur from eating certain types of fish, such as tuna and swordfish, were also tied to a higher risk of developing ADHD symptoms such as a short attention span, restlessness or being easily distracted.
Supplementation with a good quality high concentration omega3 product such as TakeOmega3 ensures that you safely increase the levels of the very important omega3 without having to worry about contamination such as Mercury . TakeOmega3 is sourced from sardines and anchovies which are at the bottom of the the food chain . Our product goes through stringent testing to ensure it is as pure as possible

TakeOmega3 the secret to anti aging ?

Wednesday, October 3rd, 2012

New research released by Ohio State University 1/10/2012 has suggested that taking high concentration omega-3 fatty acid supplements could slow a key biological process which is linked to aging . It was found in this study that most overweight but healthy middle-aged and older adults who took omega-3 supplements for four months changed a ratio of their fatty acid consumption in a way which helped to preserve tiny segments of DNA in their white blood cells.
The lengthening of telomeres in immune system cells was found to be more prevalent in people who substantially improved the ratio of omega-3s to other fatty acids in their diet, in this study. Furthermore, omega-3 supplementation reduced oxidative stress, which is caused by excessive free radicals in the blood, by about 15 percent in comparison to effects seen in the placebo group. Professor Janice Kiecolt-Glaser, the lead author of this study, has said, “The telomere finding is provocative in that it suggests the possibility that a nutritional supplement might actually make a difference in aging.”

TakeOmega3 offers the highest concentration of active ingredients of any product available in UK – each capsule contains 800mg EPA and 150mg DHA and is 90% omega3 .

Top boffins beat themselves up for science’s sake

Tuesday, October 2nd, 2012

A pair of top scientists at Dundee’s Abertay University have been beating themselves up to test the recovery properties of a unique product.
Dr John Barbraj and his colleague Dr Ross Lorimer are looking to evaluate a special formulation of a unique Omega 3 fish oil. The pair are putting the Scottish-based product, takeOmega3, through a fully controlled scientific study over an extended period. takeOmega3, which is entirely manufactured in the UK, is formulated with the highest levels of the active natural anti-inflammatory EPA available in the UK.
Dr Barbraj said: “Before we test the product on others, it seemed only fair to try it on ourselves.
“Ross and I spent time jumping off boxes, a technique known to inflict severe muscle damage to find out just how effective takeOmega3 could be.
“Previous trials and scientific papers suggest a very high EPA content in Omega 3 oils will help muscle recovery post-exercise. We wanted to prove that.”
Top sports coaches are already convinced of takeOmega3’s effectiveness. Former Scotland and British Lions international, Craig Chalmers has had his championship winning Melrose squad on the product throughout last season and this year the club is sporting the takeOmega3 logo on their shorts. And the Gloucester Rugby squad, playing in the Aviva Premiership, have also welcomed takeOmega3 as an official supplier.
takeOmega3 managing director Lesley Paton said: “We know from the feedback from the rugby players that they are convinced of our product’s unique properties.
“But John’s study should give us scientific proof. He may not be suffering for his art, but he’s certainly putting himself through the mill for the sake of science.”

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