Archive for February, 2011

Omega 3 anti obesity effects and reduction in inflammation

Wednesday, February 23rd, 2011

Fat cells may play an important role in mediating the anti-obesity effects of omega-3 rich fish oils, according to a new review.

The review, published in The Journal of Nutritional Biochemistry, suggests that omega 3 fatty acids promote changes in fat tissue (adipose tissue) metabolism, which may bring about changes in cellular signaling and secretion, contributing to improvements in glucose and lipid metabolism.

“It has been well established that adipose tissue not only is an inert storage organ but also secretes many bioactive substances,” said the authors, led by Dr Michael Puglisi from Vanderbilt University, USA.

“Various reports indicate that improved adipose (AT) tissue storage and secretory functions and a reduction in AT-specific inflammation have a central role in mediating the beneficial effects of  omega3 fish oil  against the risk factors of  metabolic syndrome” added the reviewers.

The new review focused on the mechanistic details of the cellular signaling process that modulates AT storage, and the responses to omega-3 fatty acids that modulate a response to metabolic syndrome.

The authors said that obesity has led to “alarming increases in the incidence of many chronic diseases, including type 2 diabetes and cardiovascular disease.”

They added that because over nutrition leads to obesity, the manipulation of dietary nutrient content “is a logical means of alleviating this problem.”

Along with lowering of plasma triglycerides, omega-3 rich fish oils have been found to improve insulin sensitivity and reduce blood pressure, inflammation, thrombosis and arrhythmia – contributing to a role in lowering the risk of cardiovascular disease (CVD) and diabetes.

The authors said that the liver mediated (hepatocentric) and blood lipid mediated (hypolipidemic) effects of fish oil have been extensively evaluated, “and undoubtedly play a major part in the reduction of risk for chronic disease.”But they noted that the potential adipose mediated (adipocentric) beneficial effects of fish oil have not been fully explored.

“Evidence points to the role of adipose tissue (AT) in fish oil-mediated improvements on features of metabolic syndrome, such as insulin resistance,” said Dr Puglisi and his colleagues.

Adipose tissue plays an important role in regulating lipid homeostasis by storing excess energy in the form of triglycerides.“Thus, the lipid storage function of AT is critical in buffering the daily influx of dietary fatty acids entering the circulation,” said the authors.
Adipose tissue secretes a variety of immune cell modulating molecules – known as adipokines. Fish oil has been associated “with remarkable changes in the plasma levels of two key adipokines, adiponectin and leptin,” they added.

Puglisi and co-workers explained that recent attention has been focused on the contribution of adiponectin in omega-3 mediated improvements in markers of metabolic syndromes. However, they added that emerging evidence has indicated a potential role of leptin in modulating metabolic syndrome from omega-3 intake.

“In addition to improving the storage and secretory functions of adipose tissue, fish oil, and the omega–3 fatty acids found in fish oil, have been shown to reduce inflammation in adipose tissue,” said the authors.
They explained that there is evidence to suggest such effects may be (at least in part) a result of modulation of signaling receptors such the peroxisome proliferator-activated receptor gamma (PPAR-gamma) or the inhibition of the Toll-like receptor 4 (TLR4)

Puglisi and his colleagues said there is “compelling evidence that fish oil mediates its beneficial effects on metabolic syndrome by improving adipose tissue storage and secretory functions and by reducing inflammation.”

Future studies are needed “to understand the mechanisms, in particular the role of PPAR-gamma, in modulating leptin signaling upon fish oil feeding,” said the authors.

Omega3 supplements taken daily may boost the production of muscle protein

Wednesday, February 23rd, 2011

Omega-3 may combat muscle loss associated with aging

Four grams per day of omega-3 fatty acids for eight weeks were found to increase the rate of muscle protein synthesis associated with increased supply of amino acids and insulin, according to findings published in the American Journal of Clinical Nutrition.

“Although the exact mechanisms by which omega-3 fatty acids stimulate muscle protein synthesis during hyperinsulinemia-hyperaminoacidemia remain to be resolved, our study provides compelling evidence of an interaction of omega-3 fatty acids and protein metabolism in human muscle and suggest that dietary omega-3 fatty acid supplementation could potentially provide a safe, simple, and low-cost intervention to combat sarcopenia,” wrote the researchers.

Bettina Mittendorfer, PhD, from the Division of Geriatrics and Nutritional Science at Washington University School of Medicine in Saint Louis and corresponding author of the study told that, as far as the researchers are aware, this is the first study to report potential anti-sarcopenia effects of omega-3 fatty acids.

Sarcopenia is a condition that affects the older generation, and is linked to a loss of lean body mass, strength and function.

In the US, some 45 percent of over-65 year-olds are thought to be impacted by the condition. A person in their 20s will have muscle that is up to 60 percent fat-free mass, whereas this drops to less than 40 percent for a 70 year-old.

“A major cause for the loss of muscle mass with advanced age is the inability of aging muscle to adequately increase the rate of muscle protein synthesis in response to nutritional stimuli (eg, amino acids and insulin),” explained the researchers.

Breast Cancer now affecting one in eight women can takeomega3 help prevent this disease ?

Friday, February 4th, 2011

This shocking statistic is believed to be a result of the way we now live our lives . Alcohol , lack of exercise , stress and dietary factors are all believed to contribute to this . Can omega 3 play a part in preventing women getting breast cancer ? What can women do to help reduce the risk of getting breast cancer ? These will perhaps be the questions that most women not only in UK but globally as breast cancer is a true global disease. The first study of its kind has revealed that postmenopausal women who took the omega 3 supplements reduced risk by a third.

The research, which involved 35,000 women and took six years to complete, has caused such excitement among experts that they are calling for larger and more detailed studies to urgently be carried out. Could the very action of take a high grade omega 3 supplement such as takeomega3 help in some way to prevent breast cancer ? Takeomega 3 has the highest levels of EPA currently available of any omega3 supplement with 750mg per capsule as a result it is an extremely potent anti inflammatory formulation.

They hope that it may be possible to use fish oils as a way to help women slash their risk of suffering from breast tumours.

Fish Oil contains high levels of fatty acids that can reduce inflammation. Studies have already suggested they may boost brain cells, keep eyes healthy and possibly protect against ageing.

But other studies have dismissed these claims, saying the evidence is still not there. The latest study, by a respected team in America, is the first to actively monitor women who take fish oils and see how many develop breast cancer

The team also looked at whether other supplements like St John’s Wort, soy and ginkgo biloba had any affect on the risk of tumours. All of the women in the study were between 50 and 76 and had been through the menopause.

They were asked if they had taken fish oils before or were taking them at the start of the study and how often they took them.

The team, whose study is published in the Journal of Cancer, Epidemiology, Biomarkers and Prevention, found 83 per cent took fish oils at least four times a week and 60 per cent daily. During the following six years, 880 suffered from breast cancer.

The data revealed that those who took fish oils at the start of the study had a 32 per cent reduced risk of ductal breast cancer, the most common form of the disease which affects eight in 10 sufferers.

However, there was no reduction in risk of lobular breast cancer that affects around one in 10 sufferers. Nor was there a reduced risk of women who had taken fish oils up to a decade earlier but stopped or those who took other supplements.

The team, from the Fred Hutchinson Cancer Research Center in Seattle, said the findings were interesting but it was too early to say if the fish oil is responsible. Scientists believe fish oils might work by reducing inflammation which may prevent cells from becoming damaged and turning cancerous.

Previous studies on cells in the lab and on animals both suggest fish oils might be able to protect against cancer. Scientists are keen to find an answer because more and more people have been taking supplements for decades.

This means they have been used for long enough to gauge whether they are having a positive or negative effect on long-term health. So far British experts warn against taking multi-vitamins to protect against cancer, with some warning they may increase the risk.

But the evidence on fish oils is less clear.Dr Panagiota Mitrou, deputy head of science for the World Cancer Research Fund, said: “The findings are very interesting because it is the first time fish oil has been linked to lower breast cancer risk in this type of study.

“But as the authors suggest, because this is a single study the findings are not enough for us to be confident that women can reduce their risk of breast cancer by taking fish oil supplements. More research is now needed to find out if this is actually the case.

“There is already very strong scientific evidence about how women can reduce their breast cancer risk. In fact scientists estimate that about 40 per cent of breast cancer cases in the UK could be prevented through being physically active, maintaining a healthy weight and reducing the alcohol they drink.”

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