Women with low levels omega3 and high levels omega6 associated with a high risk of pre-eclampsia

One of the most common causes of premature birth in the UK, pre-eclampsia affects 70,000 British women every year.

There were 42 per cent more casesĀ  of pre eclampsia in women who had conceived using IVF, the American Society for Reproductive Medicine’s annual conferenceĀ  heard Women who undergo IVF are often older and as a result may have an increased risk of other health problems . The general population in UK has a diet high in the pro inflammatory omega6 ie sunflower oil and low in omega3 ie oily fish . In order to address this it maybe beneficial to eat more oily fish at least 2-3 times a week ie salmon , mackerel , sardines or take high concentrate omega3 supplement which is high in active ingredients EPA and DHA such as TakeOmega3 which offers the highest concentration globally

Preeclampsia is a systemic disease characterized by diffuse endothelial dysfunction, increased peripheral vascular resistance, coagulation abnormalities, antioxidant deficiency, persistent elevations of maternal leukocyte-derived cytokines, and hyperlipidemia. Fish oil, rich in omega-3 polyunsaturated fatty acids, is known to reduce fasting and postprandial triglycerides and to decrease platelet and leukocyte reactivity; it may also decrease blood pressure. Additionally, omega-3 fatty acids may beneficially influence vessel wall characteristics and blood rheology. In light of the potential beneficial effects of dietary omega-3 fatty acids, we conducted a cross-sectional case-control study to examine the hypothesized exposure-effect relation between maternal dietary intake of marine omega-3 fatty acids and risk of preeclampsia. We measured polyunsaturated fatty acids in erythrocytes obtained from 22 preeclamptic women and 40 normotensive women; we measured polyunsaturated fatty acids as the percentage of total fatty acids from gas chromatography. We employed logistic regression procedures to estimate odds ratios (ORs) and 95% confidence intervals (CIs). After adjusting for confounders, women with the lowest levels of omega-3 fatty acids were 7.6 times more likely to have had their pregnancies complicated by preeclampsia as compared with those women with the highest levels of omega-3 fatty acids (95% CI = 1.4-40.6). A 15% increase in the ratio of omega-3 to omega-6 fatty acids was associated with a 46% reduction in risk of preeclampsia (OR = 0.54; 95% CI = 0.41-0.72). Low erythrocyte levels of omega-3 fatty acids and high levels of some omega-6 fatty acids, particularly arachidonic acid, appear to be associated with an increased risk of preeclampsia.Women

Omega-3 fatty acids in maternal erythrocytes and risk of preeclampsia.
Williams MA, Zingheim RW, King IB, Zebelman AM.
Source
Center for Perinatal Studies, Swedish Medical Center/Seattle, WA 98114-0999, USA.

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