Posts Tagged ‘which? fish oil’

Research shows that omega3 fish oil less than 80% concentrate are not effective at reducing triglyceride levels

Sunday, April 29th, 2012

t research has shown that lower concentrates omega 3 fish oil are not effective especially at reducing triglyceride levels

A study conducted in Europe showed the following that in order for omega3 to be effective in this area it required a concentration of at least 80% and above – none of the products by Nordic Naturals fall into this category or indeed any of those listed on the spreadsheet . The study concluded that “low concentration makes fish oil products impreactical for therapeutic use ”

The study looked at the Omega-3 uptake of three different Omega-3 concentrations:
62% Omega-3 (often sold as ‘Triple Strength’)
80% Omega-3
85% Omega-3
They did not test the regular ‘drug store grade’ fish oil (30% Omega-3) because it was ‘impractical’ to expect anyone to take 10 pills a day.

Every patient in the study took 5,100 mg (5.1 grams) of Omega-3 per day. However the big differentiate was the concentration levels

62% Did Not lower triglycerides

80% Did lower triglycerides

85% Did lower triglycerides

- there is an argument that omega3 at 62% Omega-3 is not pharmaceutical grade , however 80% to 85% are indeed

What was shown when they evaluated the results of the study was the following

A
There was a significant increase in blood EPA omega3 levels just after 14 days

B

The concentration levels of EPA were highest in the group taking the 85% concentration – the levels were lower in 62% and 80% group

C

The were no differences in the levels of DHA omega3 levels across the 3 groups

D

The most important factor was that the 62% omega3 concentrate did NOT lower triglycerides only the 80% and 85% omega3 fish oil did

RESULT: Even though everyone took the same amount of Omega-3, the chart below shows that 80% and 85% oils were better ‘absorbed.’

This is why it’s critical to take omega3 products such as TakeOmega3 that provide at least 80% Omega-3 concentrations.TakeOmega3 has 990mg omega3 and is an with 85% EPA /DHA concentration
It is very important that most fish oil supplements marketed as pharmaceutical grade or triple strength are only 60% omega 3 concentration

RESULT: Percent change in Triglycerides after taking 62%, 80% and 85% Omega-3 fish oil.

‘Triple Strength’ Fish Oil reduced triglycerides by less than 5% after two weeks. 80% and 85% Omega-3 oils reduced triglycerides by about 20%.
Since the FDA and other agencies does not regulate the terms like ‘pharmaceutical grade,’or ‘Triple Strength,’ anyone can call their product anything they want.However to gain CPP certification a product must fully comply with the conditions as stated by the MHRA – TakeOmega3 offers the highest concentration EPA of any formulation and is certificated by the MHRA

The reason the low concentrates dont work specifically with regards triglyceride reduction is very simple – yes its 62% omega3 but its also almost 40% or one-third non omega3 fats – whereas any oil that is 85% EPA and DHA such as TakeOmega3 will also be 90% in total omega3 as a result there is liitle if any other fatty acids. Omega-3 fats are a poor substrate for synthesis for triglycerides and Omega-3 also inhibit enzyme, acyl CoA:1,2-diacylglycerol acyltransferase due to the natural affinity Omega-3 has for this enzyme.

Harvard Medical School. Charles Serhan, a Harvard Medical School expert on Omega-3:
“The kind of benefits seen in most of the clinical trials with Omega-3 generally have involved much higher doses than you see recommended on supplement labels.”

Wall Street Journal. “Fish-Oil Doses Can Be Hard To Swallow,” David Stipp in Wall Street Journal Special Report, January 8, 2008:
“In trials aimed at lowering triglycerides, patients took three grams of Omega-3 per day. You would have to pop a daily dozen of the typical Omega-3 capsules on the market to get that.”

BENEFICIAL EFFECT OF EICOSAPENTAENOIC ACID ON ENDOTHELIAL FUNCTION IN OLD MYOCARDIAL INFARCTION PATIENTS UNDER ADEQUATE STATIN THERAPY

Sunday, April 29th, 2012

BENEFICIAL EFFECT OF EICOSAPENTAENOIC ACID ON ENDOTHELIAL FUNCTION IN OLD MYOCARDIAL INFARCTION PATIENTS UNDER ADEQUATE STATIN THERAPY

Kentaro Toyama, Osamu Sasaki, Toshihiko Nishioka and Hiroyuki Ito
Department of cardiology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan

J Am Coll Cardiol, 2012; 59:1773, doi:10.1016/S0735-1097(12)61774-4
© 2012 by the American College of Cardiology Foundation

Eicosapentaenoic acid (EPA) is reported to augment endothelial function and improve clinical outcomes in patients with coronary artery disease. However, it is unclear whether the effect of EPA is preserved even in patients under adequate statin therapy as secondary prevention. We hypothesized that EPA could improve endothelial function in old myocardial patients (OMI) with adequate lipid-lowering treatment using statin.
Fifty-five OMI patients under statin treatment with serum LDL cholesterol levels less than 100 mg/dl were randomly assigned to receive either 1800 mg of EPA daily with statin (EPA group, n=29) or statin alone (non-EPA group, n=26). Lipid profiles and flow-mediated dilation (FMD) were assessed just before and 6 months after the randomization in both groups.

EPA group presented significant increase in plasma concentrations of EPA (p<0.001). In EPA group, LDL-cholesterol and trygliceride levels significantly decreased (p<0.05), whereas no significant change was seen in non-EPA group. FMD, which is the primary end point of this study, showed significant improvement in EPA group (2.41±1.46% to 3.18±1.82%, p=0.001), while no significant change was seen in non-EPA group (2.51±1.48% to 2.25±1.42%, p=NS). Furthermore, FMD defined as post FMD - pre FMD significantly increased in EPA group (0.77±1.17 vs –0.25±1.59, p=0.009).

EPA further improved endothelial function in old myocardial infarction patients under adequate statin therapy.

What is pharmaceutical grade omega 3 fish oil

Sunday, January 22nd, 2012

Omega3
What is Pharmaceutical Grade Omega3 Fish Oil and why is Takeomega3 different from other brands ?
Pharmaceutical Grade Fish Oil
The true definition is an oil of concentration 80% -90% omega 3 such as TakeOmega3. There are a lot of omega3 products that claim to be pharmaceutical grade when they are not . Looking on the rear label makes everything clear
The majority of omega3 products on shelf are what we define as 18/12 this means 18% EPA and 12%DHA making a total of 30% omega 3. The remaining 70% is made up of monounsaturated,polyunsaturated and saturated fats. Your body has no need for these.
18/12 products are usually advertised as “1000mg Omega3” and they will have only 30% omega3 – giving a total of 300mg omega3 split 180mg EPA and 120 DHA.
Compare that to TakeOmega3 with 750mg EPA and 50mg DHA an 85% concentrate .

Benefits of Pharmaceutical Grade Fish oil such as TakeOmega3 85% Omega3
• 80% and above Omega3
• Virtually no environmental toxins the repeated molecular distillation necessary to achieve high concentrations removes virtually all toxins and heavy metals ie mercury
• Ultra purity reduces fish odour often associated with low concentration formulations
• An easy way to get high doses of omega3 with just one or two capsules as opposed to 10 capsules of low concentration brands.
• Research has shown low concentration capsules are not as effective as single dose pharmaceutical omega3 even when taking multiple capsules.
• The Omega3 fish oils used in Clinical trials / research the majority of the time pharmaceutical grade therefore why would you choose to take a low concentration oil
• You actually feel a difference .

Omega 3 Fish Oil benefits Intensifies the positive effect of Tamoxifen

Monday, April 11th, 2011

Female mice that ingested fish oil supplements with breast cancer drug tamoxifen appeared to have slowed the proliferation of their tumors, compared to rodents given corn oil with the drug, according to researchers at Fox Chase Cancer Center.

In the controlled study, the team of scientists found that the omega-3 fatty acids found in fish oil helped to slow gene expression related to tumor growth.

“If a tumor was being treated with tamoxifen, the addition of an omega-3 fatty acid diet seemed to make the tumor, at least at the molecular level, more benign and less aggressive and responsive to tamoxifen,” said lead researcher Jose Russo, M.D. TakeOmega3 due to its unique high EPA formulation with 750mg EPA per capsule and its high purity of 85% omega3 would be the ideal omega3 supplement to take alongside Tamoxifen . TakeOmega3 offers the highest concentration currently available and it is uniquely manufactured in facilities licensed by MHRA (Medical Health & Regulatory Authority) here in UK . No other omega3 supplement currently offers these benefits .

Additionally, the healthy fats appeared to curb immune responses that result in allergies and inflammation. These negative effects have been known to alter the body’s natural defense against cancer.

Next, the researchers hope to investigate how omega-3 fatty acids in a diet can affect risk of breast cancer in women.

Authors of the study noted that an estimated 200,000 women are diagnosed with the disease each year.

Breast cancer is the second most common cancer among women, with more than 200,000 women diagnosed each year. Being exposed to estrogen over a long period of time is one factor that can increase a woman’s risk of developing the disease. One way a woman can combat this risk factor is by taking the breast cancer drug tamoxifen, which interferes with the activity of estrogen. Now, researchers at Fox Chase Cancer Center have found that omega-3 fatty acids — abundant in fish — could be a safe and beneficial booster for tamoxifen therapy.

Jose Russo, MD, director of the Breast Cancer Research Laboratory at Fox Chase, is presenting the new findings at the AACR 102nd Annual Meeting 2011 on April 6.
To investigate how fish oil intensifies the effects of tamoxifen, Russo, in collaboration with a team led by Andrea Manni, MD, from Pennsylvania State University, induced mammary tumors in rats and then divided the animals into four groups. They fed the groups either a 17 percent fish oil diet, with or without tamoxifen, or a 20 percent corn oil diet, with or without tamoxifen, for eight weeks. They then analyzed gene expression patterns in the tumors. Omega-3 fatty acids produced a greater expression of genes related to cellular specialization, or differentiation — a sign of lower cancer severity — compared to corn oil. The combination of fish oil and tamoxifen reduced the expression of genes linked to tumor growth and spreading.

“The fish oil diet also boosted the expression of genes related to immune defenses against tumors, more so than did the corn oil diet. But omega-3 fatty acids simultaneously increased the expression of genes that trigger counterproductive immune responses, such as inflammation and allergic reactions, which curtail the ability of cells to fight cancer and can even promote the migration of tumor cells.

More studies are needed to fully understand the effects of fish oil on the immune system, Russo says. Meanwhile, his team is examining whether omega-3 fatty acids can prevent breast cancer in animals and testing the influence of diet on breast cancer risk in women.

Co-authors on the study include Bidinotto, L.T.; Vanegas, J.E.; Vanden Heuvel, J.P.; Lopez, R.; Santucci-Pereira, J.; Washington, S., Xu; H., Russo I.H.; El-Bayoumy, K.; and Manni, A. from Fox Chase.

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