Posts Tagged ‘prostaglandins’

Omega 3 Fish Oil EPA , DHA Marine-derived n−3 (omega-3) PUFAs may reduce risk of developing colorectal / bowel cancer 3 Cancer

Saturday, February 18th, 2012

Background: Marine-derived n−3 (omega-3) PUFAs may reduce risk of developing colorectal cancer; however, few studies have investigated the association of n−3 PUFA intakes on colorectal polyp risk.

Objective: The objective of this study was to examine the associations of dietary PUFA intake on risk of colorectal adenomatous and hyperplastic polyps.

Design: This was a colonoscopy-based case-control study that included 3166 polyp-free control subjects, 1597 adenomatous polyp cases, and 544 hyperplastic polyp cases. Dietary PUFA intake was calculated from food-frequency questionnaires and tested for association by using unconditional logistic regression. The urinary prostaglandin E2 metabolite, which is a biomarker of prostaglandin E2 production, was measured in 896 participants by using liquid chromatography and tandem mass spectrometry.

Results: n−6 PUFAs were not associated with adenomatous or hyperplastic polyps in either men or women. Marine-derived n−3 PUFAs were associated with reduced risk of colorectal adenomas in women only, with an adjusted OR of 0.67 (95% CI: 0.47, 0.97) for the highest quintile of intake compared with the lowest quintile of intake (P-trend = 0.01). Dietary intake of α-linolenic acid was associated with an increased risk of hyperplastic polyps in men (P-trend = 0.03), which was not seen in women. In women, but not in men, dietary intake of marine-derived n−3 PUFAs was negatively correlated with urinary prostaglandin E2 production (r = −0.18; P = 0.002).

Conclusion: Higher intakes of marine-derived n−3 PUFAs / omega3 from fish oil are associated with lower risk of adenomatous polyps in women, and the association may be mediated in part through a reduction in the production of prostaglandin E2. This trial was registered at clinicaltrials.gov as NCT00625066.

Dietary intake of PUFAs and colorectal polyp risk1,2,3,4
Harvey J Murff, Martha J Shrubsole, Qiuyin Cai, Walter E Smalley, Qi Dai, Ginger L Milne, Reid M Ness, and Wei Zheng

Omega 3 fish oil and benefits for athletes

Wednesday, July 20th, 2011

Omega 3 essential fatty acid EPA Reduces Inflammation
Athletes often undergo high-intensity training that increases inflammation and the risk for pain and injury. This can decrease exercise performance and the ability to recover properly. Omega-3 fatty acids fish oil specifically EPA iseffective in reducing inflammation. Researcher Dr. William Smith from the University of Massachusetts found that omega-3 fatty acids decrease inflammation by diminishing the production of prostaglandins, hormone-like substances associated with inflammation in the body. Omega 3 EPA is the most powerful natural anti inflammatory and unlike pharmaceutical anti inflammatory products there are no health risks or side effects when taking them .

Improves Body Composition
Athletes often focus on body composition, or fat to muscle ratio, in order to stay in top physical shape and maximize training and performance. In a study published in the October 2010 issue of the “Journal of the International Society of Sports Nutrition,” Eric Noreen and colleagues found that participants taking fish oil for six weeks improved their body composition by increasing lean muscle mass and decreasing fat mass. Omega 3 specifically EPA offers better oxygen delivery during exercise and also is key in removing lactic acid from the body.

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