Posts Tagged ‘omega3 restores dopamine’

Omega3 EPA maybe key to brain function ,regulates dopamine turnover and inhibits loss of myelin

Friday, January 27th, 2012

EPA levels within the brain are low in comparison to that of DHA, but this fatty acid plays an important neuroactive role and may have benefits over DHA in treating Parkinson’s disease. Firstly, EPA is a natural precursor to the synthesis of DHA and also blocks the production of an enzyme called PLA2, which releases DHA from cell membranes. By blocking this enzyme, EPA therefore helps to maintain cell membrane integrity within the brain. EPA is also a potent anti-inflammatory, and, unlike DHA, can directly inhibit the production of inflammatory products from the omega-6 arachidonic acid, which themselves are known to contribute to the progression of Parkinson’s. EPA, again preferentially over DHA, is also involved in myelinogenesis by stimulating the production of several myelin proteins which are thought to be key to the inhibition of loss of myelin and therefore brain atrophy.3,4 More recently, EPA has been suggested to regulate dopamine turnover and down-regulate genes involved in neuronal cell death pathways, thus further supporting a beneficial role for ethyl-EPA supplementation as both a preventative and therapeutic tool in neurodegenerative

Oral fish oil restores striatal dopamine release after traumatic brain injury.

Thursday, July 28th, 2011

Omega 3 Fish oil taken orally  restores striatal dopamine release after traumatic brain injury.

Brain Trauma Research Center, Department of Neurosurgery, University of Pittsburgh, 3434 Fifth Ave, Suite 201, Pittsburgh, PA 15260, USA.
Omega-3 fatty acid administration can affect the release of neurotransmitters and reduce inflammation and oxidative stress, but its use in traumatic brain injury (TBI) has not been described extensively. We investigated the effect of 7 day oral fish oil treatment in the recovery of potassium evoked dopamine release after TBI. Sham rats and TBI rats were given either olive oil or fish oil orally and were subject to cerebral microdialysis. Olive oil treated TBI rats showed significant dopamine release deficit compared to sham rats, and this deficit was restored with oral fish oil treatment. There was no effect of fish oil treatment on extracellular levels of dopamine metabolites such as 3,4-dihydroxyphenylacetic acid and homovanillic acid. These results suggest the therapeutic potential of omega-3 fatty acids in restoring dopamine neurotransmission deficits after TBI.

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