Posts Tagged ‘omega3 and breast cancer’

High strength Omega3 appears to inhibit breast cancer cell growth

Wednesday, January 16th, 2013

Although evidence has shown the regulating effect of n-3 poly-unsaturated fatty acid (n-3 PUFA) marine sourced omega3 fish oil on cell signaling transduction, it remains unknown whether n-3 PUFA treatment modulates estrogen signaling.

The current study showed that docosahexaenoic acid (DHA, C22:6), eicosapentaenoic acid (EPA, C20:5) shifted the pro-survival and proliferative effect of estrogen to a pro-apoptotic effect in human breast cancer (BCa) MCF-7 and T47D cells. 17 β-estradiol (E2) enhanced the inhibitory effect of n-3 PUFAs on BCa cell growth. The IC50 of DHA or EPA in MCF-7 cells decreased when combined with E2 (10 nM) treatment (from 173 µM for DHA only to 113 µM for DHA+E2, and from 187 µm for EPA only to 130 µm for EPA+E2). E2 also augmented apoptosis in n-3 PUFA-treated BCa cells. In contrast, in cells treated with stearic acid (SA, C18:0) as well as cells not treated with fatty acid, E2 promoted breast cancer cell growth. Classical (nuclear) estrogen receptors may not be involved in the pro-apoptotic effects of E2 on the n-3 PUFA-treated BCa cells because ERα agonist failed to elicit, and ERα knockdown failed to block E2 pro-apoptotic effects. Subsequent studies reveal that G protein coupled estrogen receptor 1 (GPER1) may mediate the pro-apoptotic effect of estrogen. N-3 PUFA treatment initiated the pro-apoptotic signaling of estrogen by increasing GPER1-cAMP-PKA signaling response, and blunting EGFR, Erk 1/2, and AKT activity.

These findings may not only provide the evidence to link n-3 PUFAs omega 3 biologic effects and the pro-apoptotic signaling of estrogen in breast cancer cells, but also shed new insight into the potential application of n-3 PUFAs in Breast Cancer treatment.

Lower Breast Cancer Events in Survivors with Higher Omega-3 fish oil Consumption- specifically EPA

Sunday, July 10th, 2011

Links between the chance of developing breast cancer and the consumption of fat or individual fatty acids have been around for years, but the research findings have been all over the map. Animal and cell culture studies have often reported links between omega-3 fatty acids from seafood and lower growth and spread of breast cancer tumors, but these findings have not consistently carried over into human studies. Nevertheless, the topic continues to be investigated. A systematic review of the scientific literature a few years ago analyzed 10 studies in humans and concluded there was about a 30% lower risk of breast cancer in women with higher intakes of seafood omega-3s.

Investigators in California asked a different question about the possible links between fish or omega-3 consumption and breast cancer. They focused on breast cancer survivors. The researchers asked whether omega-3 intakes affect a woman’s disease-free survival or subsequent breast cancer events after she has been treated for early-stage breast cancer. Participants in the study were enrolled in the Women’s Healthy Eating and Living Study, which was designed to learn whether eating more vegetables, fruits and fiber affected the risk of recurrent or new primary breast cancer. The study included women from the ages of 18 to 70 who were monitored over a 7-year period.

Food intake information was obtained when the women entered the study. The women were assessed for their health outcomes and the development of any cancer at intervals from 1 to 6 years after the study began. At the beginning of the study, the women consumed an average of 186 mg per day of the long-chain omega-3s found in seafood. This is nearly double the amount consumed by the general population.

After 6 years, their intake had increased to 237 mg per day, an increase of 27%. This change was unrelated to the study. Women’s use of fish oil supplements also increased during that time from 4% to 10% of women. The investigators found that the increase in omega-3s was significant for women who did not experience additional breast cancer events, but not among those who had additional events. An “event” was considered to be a recurrent cancer or a new invasive breast cancer.
The key finding was that women in the upper two-thirds of long-chain omega-3 intakes experienced a 25% reduction in the likelihood of developing an additional breast cancer event. Higher omega-3 intakes ranged from a median of 73 to 365 mg per day. It made no difference whether the omega-3s came only from food or from food plus supplements. The investigators also noted that women in the highest third of omega-3 consumption were 40% less likely to die from breast cancer compared with women in the lowest third of omega-3 consumption. The cutoff for the highest omega-3 intake was 153 mg/day or more.

Omega 3 Fish Oil benefits Intensifies the positive effect of Tamoxifen

Monday, April 11th, 2011

Female mice that ingested fish oil supplements with breast cancer drug tamoxifen appeared to have slowed the proliferation of their tumors, compared to rodents given corn oil with the drug, according to researchers at Fox Chase Cancer Center.

In the controlled study, the team of scientists found that the omega-3 fatty acids found in fish oil helped to slow gene expression related to tumor growth.

“If a tumor was being treated with tamoxifen, the addition of an omega-3 fatty acid diet seemed to make the tumor, at least at the molecular level, more benign and less aggressive and responsive to tamoxifen,” said lead researcher Jose Russo, M.D. TakeOmega3 due to its unique high EPA formulation with 750mg EPA per capsule and its high purity of 85% omega3 would be the ideal omega3 supplement to take alongside Tamoxifen . TakeOmega3 offers the highest concentration currently available and it is uniquely manufactured in facilities licensed by MHRA (Medical Health & Regulatory Authority) here in UK . No other omega3 supplement currently offers these benefits .

Additionally, the healthy fats appeared to curb immune responses that result in allergies and inflammation. These negative effects have been known to alter the body’s natural defense against cancer.

Next, the researchers hope to investigate how omega-3 fatty acids in a diet can affect risk of breast cancer in women.

Authors of the study noted that an estimated 200,000 women are diagnosed with the disease each year.

Breast cancer is the second most common cancer among women, with more than 200,000 women diagnosed each year. Being exposed to estrogen over a long period of time is one factor that can increase a woman’s risk of developing the disease. One way a woman can combat this risk factor is by taking the breast cancer drug tamoxifen, which interferes with the activity of estrogen. Now, researchers at Fox Chase Cancer Center have found that omega-3 fatty acids — abundant in fish — could be a safe and beneficial booster for tamoxifen therapy.

Jose Russo, MD, director of the Breast Cancer Research Laboratory at Fox Chase, is presenting the new findings at the AACR 102nd Annual Meeting 2011 on April 6.
To investigate how fish oil intensifies the effects of tamoxifen, Russo, in collaboration with a team led by Andrea Manni, MD, from Pennsylvania State University, induced mammary tumors in rats and then divided the animals into four groups. They fed the groups either a 17 percent fish oil diet, with or without tamoxifen, or a 20 percent corn oil diet, with or without tamoxifen, for eight weeks. They then analyzed gene expression patterns in the tumors. Omega-3 fatty acids produced a greater expression of genes related to cellular specialization, or differentiation — a sign of lower cancer severity — compared to corn oil. The combination of fish oil and tamoxifen reduced the expression of genes linked to tumor growth and spreading.

“The fish oil diet also boosted the expression of genes related to immune defenses against tumors, more so than did the corn oil diet. But omega-3 fatty acids simultaneously increased the expression of genes that trigger counterproductive immune responses, such as inflammation and allergic reactions, which curtail the ability of cells to fight cancer and can even promote the migration of tumor cells.

More studies are needed to fully understand the effects of fish oil on the immune system, Russo says. Meanwhile, his team is examining whether omega-3 fatty acids can prevent breast cancer in animals and testing the influence of diet on breast cancer risk in women.

Co-authors on the study include Bidinotto, L.T.; Vanegas, J.E.; Vanden Heuvel, J.P.; Lopez, R.; Santucci-Pereira, J.; Washington, S., Xu; H., Russo I.H.; El-Bayoumy, K.; and Manni, A. from Fox Chase.

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