Posts Tagged ‘omega 3 for Arthritis’

Omega-3 research sheds light on inflammation trigger

Tuesday, August 16th, 2011

BBSRC-funded scientists at the University of Birmingham have discovered a previously unknown step in early inflammation which is controlled by omega –3 and omega –6 fatty acids, potentially leading to clarification around conflicting health and diet advice on these two essential nutrients.

Dr Ed Rainger, from the Centre for Cardiovascular Sciences at the University, has discovered that a key product in the metabolism of omega –6 fatty acids is an essential signal for neutrophils (white blood cells that form an essential part of the immune system) to cross the endothelium, the thin layer of cells that line the interior surface of blood vessels, to work on inflammation.

Dr Rainger says the findings of the study, funded by BBSRC and the British Heart Foundation, will open up new possibilities: “The identification of these novel mechanisms by which inflammation is regulated may allow us to develop new therapies to intervene when the process of inflammation becomes pathological rather than physiological.”

These latest discoveries bolster the evidence that fish oils have anti-inflammatory effects in addition to other health benefits. Dr Rainger and his team have revealed new steps in the body’s response to tackling inflammation which researchers hope will lead to designing potential new drugs to tackle severe and chronic disease such as rheumatoid arthritis.

The team also found that the migration of neutrophils could be blocked by the increased levels of omega -3 generated after the endothelial cells had been supplemented with this omega –3 fatty acid.

Dr Rainger and his team conducted the study using a realistic, flow based system that models the process of inflammation at the interface of the circulating blood and inflamed tissue. They were then able to observe the effects of physiological levels of omega –3 and omega –6 fatty acids on the process of recruiting inflammatory blood cells such as neutrophils into the tissue. This process is regulated by endothelial cells lining the blood vessels.

Dr Ed Rainger, said: “Our findings are very significant. They support the idea that omega–6 fatty acids are pro-inflammatory – that they are required to sustain a normal inflammatory response without which we would be prone to serious infection and tissue damage.”

Conversely, Dr Rainger has uncovered mechanistic evidence that supports the anti-inflammatory role of omega -3 fatty acids: “We’ve all heard about the health benefits of eating oily fish, and its beneficial effects on cardiovascular health, possibly due to their anti inflammatory properties, yet little is known about the normal cellular mechanisms by which omega –3 fatty acids produce their protective effects.”

Nutritionists believe that imbalances in omega –3 and –6 – may explain the rise of diseases such as asthma, coronary heart disease, cancers, autoimmunity and neurodegenerative diseases, all of which are believed to stem from inflammation in the body.

Paper: Fatty acids and Inflammation: novel interactions reveal a new step in neutrophil recruitment is published in PLoS Biology on 25 August.

Rheumatoid Arthritis benefits of omega 3 fish oil

Tuesday, May 3rd, 2011

There has been great interest in the use of omega3 fish oil EPA and DHA which is a key anti inflammatory . There have been numerous studies sine the early 1980’s looking at the benefits in taking omega 3 fish oil both as a preventative measure as well as therapeutic treatment for the condition. There are at least 13 randomized clinical controlled studies that show clear benefits of taking fish oil – a common outcome in these studies has been a reduction in symptoms and tender joints. More importantly there was a reduction in analgesic anti inflammatory drugs used . For those people who have a family history of rheumatoid arthritis they should look to make dietary changes and decrease the amount of omega 6 they take which is pro inflammatory and increase the omega3 specifically EPA / DHA the key active ingredients

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