Posts Tagged ‘omega 3 and cancer’

Omega-3 fish oil is Linked To Decreased Inflammation And Decreased Fatigue in Breast Cancer

Saturday, March 17th, 2012

Omega-3 fish oil is Linked To Decreased Inflammation And Decreased Fatigue in Breast Cancer – Omega 3 active ingredient EPA is the most potent natural anti inflammatory
Alfano CM, Imayama I, Neuhouser ML, et al. Fatigue, Inflammation, and ω-3 and ω-6 Fatty Acid Intake Among Breast Cancer Survivors. J Clin Oncol. 2012 Mar 12.
PURPOSE: Evidence suggests that inflammation may drive fatigue in cancer survivors. Research in healthy populations has shown reduced inflammation with higher dietary intake of Omega 3 ω-3 polyunsaturated fatty acids (PUFAs), which could potentially reduce fatigue. This study investigated fatigue, inflammation, and intake of Omega 3 ω-3 and Omega 6 ω-6 PUFAs among breast cancer survivors.

METHODS: Six hundred thirty-three survivors (mean age, 56 years; stage I to IIIA) participating in the Health, Eating, Activity, and Lifestyle Study completed a food frequency/dietary supplement questionnaire and provided a blood sample assayed for C-reactive protein (CRP) and serum amyloid A (30 months after diagnosis) and completed the Piper Fatigue Scale and Short Form-36 (SF-36) vitality scale (39 months after diagnosis). Analysis of covariance and logistic regression models tested relationships between inflammation and fatigue, inflammation and Omega3 ω-3 and Omega 3 ω-6 PUFA intake, and PUFA intake and fatigue, controlling for three incremental levels of confounders. Fatigue was analyzed continuously (Piper scales) and dichotomously (SF-36 vitality ≤ 50).

Results: Behavioral (P = .003) and sensory (P = .001) fatigue scale scores were higher by increasing CRP tertile; relationships were attenuated after adjustment for medication use and comorbidity. Survivors with high CRP had 1.8 times greater odds of fatigue after full adjustment (P < .05). Higher intake of ω-6 relative to ω-3 PUFAs was associated with greater CRP (P = .01 after full adjustment) and greater odds of fatigue (odds ratio, 2.6 for the highest v lowest intake; P < .05).

CONCLUSION: Results link higher intake of Omega3 ω-3 PUFAs, decreased inflammation, and decreased physical aspects of fatigue. Future studies should test whether Omega3 ω-3 supplementation may reduce fatigue among significantly fatigued breast cancer survivors.

Omega3 highest concentration is found in takeomega3 which is high in the active omega3 EPA - the most potent natural anti inflammatory . TakeOmega3 is a unique pharmaceutical grade formulation manufactured in MHRA facilities in the UK . It is an 85% concentration with each capsule containing 750mg EPA and 50mg DHA.

Omega-3 fatty acid supplementation in cancer therapy : does omega 3 EPA ( eicosapentanoic acid) influence the radiosensitivity of tumor cells?

Tuesday, September 13th, 2011

Omega-3 fatty acid supplementation in cancer therapy : does eicosapentanoic acid influence the radiosensitivity of tumor cells?

Manda K, Kriesen S, Hildebrandt G, Fietkau R, Klautke G.

Department of Radiotherapy, University of Rostock, Rostock, Germany.



The aim of this study was to evaluate whether the omega-3 polyunsaturated fatty acid cis-5,8,11,14,17-eicosapentanoic acid (EPA) can enhance the radiosensitivity of different human tumor cell lines.


Colon adenocarcinoma cells HT-29, and two glioblastoma multiforme tumor cells T98G and U251 were cultured under standard conditions. Cell growth was observed during administration with different concentrations of EPA, using it as the free fatty acid dissolved in ethanol or bound to bovine serum albumin. To investigate the influence of EPA (free and bound) on radiosensitivity, tumor cells were pretreated 30 minutes or 24 hours prior to irradiation with the fatty acid. Cell survival was measured by colony-forming assays.


When combined with irradiation, incubation with EPA was found to result in enhanced radiosensitivity with substantial variation: while there was strong radiosensitization for HT-29 and U251 cells, almost no effect for T98G cells was observed. A marked radiosensitization was clearly dependent on the treatment schedule.


The observations suggest that EPA is not only a nutritional adjuvant but also may be a potential candidate to enhance the efficacy of irradiation on human cancer cells.

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