Posts Tagged ‘manic depression’

Omega 3 Essential Fatty Acids are essential for optimal brain function

Saturday, October 8th, 2011

Omega 3 Essential Fatty Acids are essential for optimal brain function .During times of stress these essential nutrients are even more critical , the body cannot manufacture these nutrients themselves so they have to be provided by diet . The best sources of omega 3 essential fatty acids are those from oily fish such as sardines , anchovies , mackerel , salmon or you can take an omega 3 supplement – you should look for one that is both high concentration about 80% is preferred and high in active ingredient EPA . Unfortunately the majority of omega 3 products available to the consumer tend to be low concentration and low in EPA .
Research is now showing that deficiencies in these brain critical nutrients may manifest in mental health disorders such as major depression , suicidal tendancies , psychiatric disorders , developmental problems and impulsive violence. As well as that there are possible links re low omega 3 consumption and the increase in neurodegenerative disorders . Omega 3 fatty acids such eicosapentaenoic acid (EPA and docosahexaenoic (DHA) in particular are involved in many neuronal functions , Due to the reduction of omega 3 in todays modern diet there is more and more research being carried out re the benefits of omega3 especially EPA on the brain. The modern diet has a high ratio of omega 6 and a low ratio of omega 3 . Omega3 especially EPA is believed to be critical with regards the myelin sheaths ,Myelin is an insulating layer that forms around nerves, including those in the brain and spinal cord. It is made up of protein and fatty substances.
The purpose of the myelin sheath is to allow impulses to transmit quickly and efficiently along the nerve cells. If myelin is damaged, the impulses slow down.It is believed the omega3 active ingredients ie EPA not only acts as an anti inflammatory but also helps repair damage to the brain by promoting neuronal growth.

Eicosapentaenoic Acid – EPA Omega 3 essential fatty acid

Thursday, August 11th, 2011

Eicosapentaenoic Acid – EPA Omega 3 essential fatty acid

Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families. EPA is considered to be the most powerful anti inflammatory and is the key essential fatty acid with regards mental health disorders such as depression , bi polar , schizophrenia .

Low plasma levels of Omega3 essential fatty acid EPA are associated with bipolar disorder

Friday, July 29th, 2011

Low plasma levels of EPA are associated with bipolar disorder
Sublette M, Bosetti F, DeMar J, et al. Plasma free polyunsaturated fatty acid levels are associated with symptom severity in acute mania. Bipolar Disorder / Manic Depression
OBJECTIVES: Nutritionally essential polyunsaturated fatty acids (PUFAs) have been implicated as potentially important factors in mood disorders. For instance, n-3 PUFA supplementation is reported to improve outcomes in major depressive disorder and bipolar disorder. However, the role of PUFAs in acute mania has been minimally investigated. We performed a pilot study to compare plasma levels of free (non-esterified) and esterified PUFAs between patients in an acute manic episode and healthy volunteers, and to explore associations between symptom severity and levels of fatty acids and of the arachidonic acid metabolite, prostaglandin E2 (PGE2).

METHODS: Patients (n=10) who were medication-free for at least two weeks and seeking inpatient admission for an acute manic episode were compared with healthy volunteers (n=10). Symptom severity was assessed at admission and after six weeks of naturalistic treatment. Fasting baseline free and esterified plasma levels of docosahexaneoic acid (DHA, 22:6n-3), eicosapentaenoic acid (EPA, 20:5n-3), arachidonic acid (AA,20:4n-6) and the AA metabolite PGE2 were determined, and PGE2 levels were tested again at six weeks.

RESULTS: No between-group differences were found in levels of individual or total fatty acids, or of PGE2. Among subjects, manic symptom severity correlated negatively with levels of free AA and free EPA, and positively with the free AA:EPA ratio. PGE2 levels did not differ between groups or in subjects pre- and post-treatment.

CONCLUSIONS: Our preliminary results suggest that, in susceptible persons, low plasma levels of free EPA compared with AA are related to the severity of mania.

Great Britain Flag
Made in the UK - Take Omega 3 Suspendisse lacinia ultricies justo, at ultricies nisi tempus ac. Cras sed vehicula metus. Phasellus...