Posts Tagged ‘highest concentration omega3’

Omega 3 : omega 6 – the rise of chronic disease and illness

Saturday, September 22nd, 2012

The human body can synthesise all fatty acids with the exception of omega3 and omega 6 . They are known as essential fatty acids or EFA’S they are the building blocks of cell membranes – brain tissue and nerve tissue – they are essential for the functioning of every cell in your body .They help protect against chronic health conditions and disease , they repair degenerative cells and ensure that the body is fuelled properly . The ideal scenario would be to have a ratio of 1:1 omega 6 : omega 3 this however as we shall see is not the case and the actual ratio in UK , USA , UAE and countries following a westernised diet maybe as much as 25 : 1 omega 6 : omega 3 .

To put this in perspective taking breast cancer as an example studies have shown that an excessive food based intake of Omega – 6( linoleic acid ) is linked to some forms of breast cancer , in subjects whose breast tissue contains high levels of omega-3 they appear to be less prone to this form of cancer which affects 1 in 8 women.

In order to maintain levels of these very important EFA’s you have to take them from food sources – what has happened in the last Century is that there has been an increase in the consumption of Omega 6 (linoleic acid) and a decrease in consumption of Omega 3 ( alpha linoleic acid )

Fats can be divided into two groups saturated and unsaturated fatty acids . Saturated fats are from animals sources , unsaturated fats are your omega 3 , omega 6 and omega 9 . Omega 9 is also known as Oleic acid .

Omega 6 is converted in your body into arachodonic acid (AA) Omega 3 is converted into eicosapentaenoic acid (EPA ) and docosahexaenoic acid (DHA) the secret to good health is to have a balance between the omega 6 and omega 3 . Unfortunately in our modern diet we consume too much omega 6 and too little omega 3 and it is this inbalance that has resulted in so many of the health problems affecting the population . Part of the problem is the intense farming methods and what we feed animals on as well as that a lot of fish in fish farms are fed an artificial diet so the farmed fish contains less omega 3 than wild cold water fish which feeds on krill . The most common source s of omega 6 in our modern diet is sunflower oil , corn oil , groundnut oil , hemp , safflower and soya oils . These oils are used extensively in the modern food industry just look at the labels of the food you buy – bread , pizza, margarines , ready meals .

A diet high in omega 6 is one that is pro inflammatory – this is due to the fact your body produces more prostaglandins which promote inflammation – inflammation is what precedes disease and many diseases are aggrevated by inflammation ie arthritis , type 2 diabetes , IBD , psoriasis etc . With the western diet showing a ratio of around 25: 1 omega 6 (pro inflammatory ) : omega 3 (anti inflammatory ) it is easy to see what has gone wrong and why we have the increase in so many chronic conditions .

The simple solution is obviously to increase intake of the anti inflammatory omega 3 – EPA and DHA and decrease intake of the pro inflammatory omega 6 sunflower oils , corn oil etc . Very often the simplest way is for most people is to take an omega3 supplement however due to the clever marketing of the companies finding the right supplement is difficult .

You need a supplement that is high in active ingredients specifically EPA which is believed to be the most potent natural anti inflammatory . Takeomega3 has 800mg EPA per capsule which is far in excess of any other omega3 product on shelf – surprisingly the brands advertising 1000mg omega3 are only 30% active ingredients and the other 70% is fat which you dont need !! ., TakeOmega 3 is 90% active ingredients. Research has shown that for an omega3 supplement to be effective it needs to be 80% active ingredients none of the brands on UK shelves offer this . They label highest concentration , pure omega3 , 1000mg omega3 but at the end of the day they are lowin the active ingredients and as a result are not effective . Why waste money on a product that could be as much as 80% fat that you dont need ?

Omega 3 EPA the key omega3 to tackle obesity and type 2 diabetes

Saturday, October 8th, 2011

A major risk factor for cardiovascular disease, type 2 diabetes
and other pro inflammatory life-threatening conditions is the current obesity epidemic which is endemic in developed nations such as United States , United Kingdom , UAE where it’s fueled in large part by excessive consumption of a fat-rich “Western style diet.” The main issue is the increase consumption of saturated fats which are pro inflammatory ie animal fats , sunflower oil , corn oil etc Animal-derived saturated fats like lard and butter are strongly linked to adverse health effects, but unsaturated and polyunsaturated fats from plants and cold-water fish like salmon and mackerel are not. In fact, eating oily fish which is rich in omega3 especially EPA produces beneficial health effects and can reduce the risk of cardiovascular disease and diabetes
For biomedical investigators, the enduring question has been why saturated and unsaturated fatty acids produce such diametrically opposed health effects. Now, in a paper published in the Sept. 30 issue of the journal Cell, researchers at the University of California San Diego School of Medicine and colleagues offer an explanation, and a framework that could lead to dietary supplements designed to treat obesity at the molecular level.

“These findings not only explain the long-standing enigma regarding the differential health effects of saturated and unsaturated fatty acids,” said senior author Michael Karin, PhD, Distinguished Professor of Pharmacology in UC San Diego’s Laboratory of Gene Regulation and Signal Transduction, “they also provide improved tools and a mechanistic framework for the potential development of dietary supplements to treat obesity, estimated to be worth billions of dollars per year.”

Senior author Karin, first author Ryan G. Holzer, PhD, formerly a graduate student in Karin’s lab and now at the Mayo Clinic, and colleagues began with the observation that saturated fatty acids, such as palmitic acid, are potent activators of Jun kinases (JNK), key regulatory molecules implicated in the development of type 2 diabetes, insulin resistance, obesity and atherosclerosis. However, unsaturated fatty acids such as palmitoleic acid (POA) and eicosapentaenoic acid (EPA) not only do not activate JNK, but actually block JNK activation by palmitic acid.

Palmitic acid and POA differ in molecular structure by the presence of a single unsaturated bond (the absence of two hydrogen atoms) in POA. Cellular membrane fluidity is decreased upon incorporation of saturated fatty acids, which possess rigid hydrocarbon tails, but increased by the incorporation of unsaturated fatty acids with “bent” hydrocarbon tails.

Postulating that the membrane is the only cellular structure that can discriminate between all of these fatty acids, the scientists searched for membrane-associated protein kinases that could account for the differential effects on JNK activity. They ultimately identified c-Src, a membrane-associated tyrosine kinase, as the molecule responsible for activation of JNK by palmitic acid and other saturated fatty acids. They also discovered that saturated fatty acids “push” c-Src into membrane sub-domains of reduced fluidity and increased rigidity, where it accumulates in an activated form that eventually leads to JNK activation.

By contrast, POA and EPA prevent these changes in the membrane distribution of c-Src and — by blocking c-Src aggregation — they inhibit its activation by saturated fatty acids.

Most of the research was conducted using cultured cells (fibroblasts) treated with individual or combined fatty acids, but the scientists also fed mice a high-fat diet (in which 60 percent of the calories were fat-derived) and reported similar c-Src accumulation within membrane subdomains of increased rigidity and JNK activation.

Currently, polyunsaturated fatty acids, such as EPA and structurally-related omega-3 fatty acids are used in the treatment of hyperlipidemia (high blood cholesterol levels) and may be effective in the treatment or prevention of type 2 diabetes. Karin said understanding how EPA works could lead to the identification of even more potent EPA-like molecules.

Funding for this research came from the National Institutes of Health, the Superfund Basic Research Program and the American Diabetes Association.

Co-authors of the paper are Eek-Joong Park, Ning Li, Helen Tran, Monica Chen and Crystal Choi, Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, UC San Diego; and Giovanni Solinas, Laboratory of Metabolic Stress Biology, Department of Medicine, Physiology, University of Fribourg, Switzerlan

Consumption Of Omega-3 essential Fatty acid fish oils Decrease Homocysteine Levels In Diabetic Patients

Friday, July 29th, 2011

Consumption Of Omega-3 FAs Decrease Homocysteine Levels In Diabetic Patients
Pooya S, Jalali MD, Jazayery AD, et al. The efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patients. Nutr Metab Cardiovasc Dis. 2009;18.
BACKGROUND AND AIMS: Cardiovascular diseases are the major cause of mortality among diabetic patients. The concentration of malondialdehyde (MDA) and homocysteine is believed to play a role in cardiovascular diseases. Omega-3 fatty acid supplementation could be effective in some diabetes complications and in the control of the glycemic index. However, it may increase lipid peroxidation. The objective of this study was to determine the effect of omega-3 fatty acids on the concentration of homocysteine and MDA in diabetic patients.

METHODS AND RESULTS: A randomized double-blind, placebo-controlled clinical trial was conducted on 81 patients with type 2 diabetes. The patients were randomly assigned to either the treatment or control groups. Each subject received three capsules of omega-3 fatty acids or a placebo every day for a period of 2months. The two groups were similar in terms of body mass index and food intake. At the beginning of the study and after 2months of supplementation their levels of HbA(1)c, homocysteine, MDA, C-reactive protein (CRP), total cholesterol, LDL-cholesterol and fasting blood sugar (FBS) were determined. Due to omega-3 fatty acid supplementation, homocysteine was changed significantly in both treatment and control groups up to -3.10mumol/L and 0.10mumol/L respectively, and HbA(1)c decreased by 0.75% in the treatment group and increased by 0.26% in the control group. However, the changes in fasting blood sugar (FBS), malondialdehyde (MDA), C-reactive protein (CRP), total cholesterol and LDL-cholesterol levels were not significant.

CONCLUSION: The consumption of omega-3 fatty acid supplements (3g/day) for 2months decreases the levels of homocysteine in diabetic patients with no change in FBS, MDA and CRP levels.

Omega 3 EPA reduces LDL cholesterol levels – TakeOmega3 has 750mg EPA per capsule

Wednesday, December 15th, 2010

New clinical study results presented at the American Heart Association Scientific Sessions show that the long-chain omega-3 fatty acid EPA (eicosapentaenoic acid), helped significantly reduce small dense LDL (bad) cholesterol levels.

“This study suggests that supplementation with the omega-3 fatty acid EPA may present unique benefits for cardiovascular health,” said Sujata K. Bhatia, M.D., Ph.D., research associate with DuPont. “EPA was shown to have advantageous effects on several biomarkers, including LDL cholesterol, small dense LDL, and lp-PLA2.”

EPA is a long-chain fatty acid that is found primarily in cold water, fatty fish like sardines anchovies mackerel  as well as some omega-3 fatty acid such as TakeOmega3 which has 750 mg EPA per capsule  and is the highest grade omega 3 available in UK . A growing body of evidence suggests that EPA is the long-chain omega-3 that supports heart health.

The study, conducted by Cardiovascular Research Associates and sponsored by DuPont, was conducted among 110 healthy individuals comparing the effects of EPA supplements to DHA (docosahexaenoic acid) supplements on cardiovascular health. The participants were placed into four study groups and examined over a six week period. During that time, each group was monitored while taking: EPA 600 mg per day; EPA 1,800 mg per day; DHA 600 mg per day; and an olive oil placebo.

The study found that in the 1,800mg EPA group, there were significant reductions of 7 percent for small dense low density lipoprotein (LDL) cholesterol, and 6 percent for lipoprotein-associated phospholipase A2 (lp-PLA2). lp-PLA2 is an enzyme involved in vascular inflammation.
In contrast, the 600mg DHA group showed a significant increase in total small dense LDL cholesterol in both the fasting and fed state of 14.2 percent and 16.3 percent respectively.

The study results will be featured during the American Heart Association Conference poster session in Chicago

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