Posts Tagged ‘highest concentration fish oil’

Omega3 Fatty acid EPA most potent omega3 for inflammation and healing in athletes Omega3 EPA accelerates ligament healing

Tuesday, July 24th, 2012

Omega3 Fatty acid EPA most potent omega3 for inflammation and healing in athletes – TakeOmega3 HFL tested
Omega3 EPA accelerates ligament healing

Ligaments are tough bands of fibrous connective tissue (mainly collagen) that link two bones together at a joint. Injuries to ligaments are notoriously slow to heal. Researchers at Purdue University now report the results of an intriguing experiment which shows that eicosapentaenoic acid (EPA – one of the acitive ingredients iin fish oil materially speeds up the healing of “wounded” ligament cells in vitro. The experiment was carried out on three cultures of animal medial collateral ligament cells. The first culture was treated with arachidonic acid (an n-6 polyunsaturated fatty acid), the second with eicosapentaenoic acid (an n-3 polyunsaturated fatty acid), and the third served as a control.
After four days the cells were analyzed to determine their fatty acid profile. The AA (arachidonic acid) treated cells were found to have an n-6 to n-3 ratio of 24.3 while the EPA (eicosapentaenoic acid) treated cells had a ratio of 1.1. This indicates that the two fatty acids were well-absorbed and incorporated into the cells. Next a “wound” was introduced into the surface layers of the cell cultures by streaking a sterile pipette across them. The rate at which ligament cells grew back into the “wound” was measured over a 72-hour period and taken as an indication of wound healing speed. Both the AA and EPA treated cultures showed a higher degree of regrowth in the wound area than did the control. However, while AA decreased the synthesis of collagen by the ligament cells, EPA markedly increased it.
The researchers conclude that dietary supplementation with omega3 fish oils specifically EPA (n-3 polyunsaturated fatty acid) could be used to improve the healing of ligament injuries by enhancing the entry of new cells into the wound area and by speeding up collagen synthesis.
Source
Hankenson, Kurt D., et al. Omega-3 fatty acids enhance ligament fibroblast collagen formation in association with changes in interleukin-6 production. Proceedings of the Society for Experimental Biology and Medicine

Omega 3 and chronic tendon disorders in athletes
Does Omega 3 have any benefit in the treatment of chronic tendon disorders ? This is a major problem amongst recreational athletes and we do get asked if taking a high dose omega 3 such as Take Omega3 which is high in the key anti – inflammatory essential fatty acid EPA and is also HFL tested would be of any help . Several years ago there was a study conducted whereby they evaluated treatment with essential fatty acids and antioxidants combined with physiotherapy.
Methods and measures
In a randomised, double-blind, placebo-controlled trial 40 volunteers active in recreational sports with chronic tendon disorders were assigned to the study. The subjects were divided in two groups, one consuming a daily dosage of essential fatty acids and antioxidants and one consuming similar placebo. Furthermore, the subjects received 16 sessions of ultrasound treatment over 32 days. Evaluation was pain scores, rated on a visual analogue scale and quantification of normal sports activity during treatment.
Results
In the treatment group there was a significant reduction of pain compared with the placebo group (P<0.001) after 32 days. There was a mean decrease in pain score of 99% in the treatment group compared with a mean decrease of 31% in the placebo group. Sport-specific activity increased by 53% in the treatment group and increased by 11% in the placebo group.
Conclusions
The results suggest beneficial effect of essential fatty acids and antioxidants in combination with physiotherapy treating chronic tendon disorders.

Omega 3 essential fatty acid EPA Reduces Inflammation
Athletes often undergo high-intensity training that increases inflammation and the risk for pain and injury. This can decrease exercise performance and the ability to recover properly. Omega-3 fatty acids fish oil specifically EPA is effective in reducing inflammation. Researcher Dr. William Smith from the University of Massachusetts found that omega-3 fatty acids decrease inflammation by diminishing the production of prostaglandin's, hormone-like substances associated with inflammation in the body. Omega 3 EPA is the most powerful natural anti inflammatory and unlike pharmaceutical anti inflammatory products there are no health risks or side effects when taking them .
Improves Body Composition

Athletes often focus on body composition, or fat to muscle ratio, in order to stay in top physical shape and maximise training and performance. In a study published in the October issue of the “Journal of the International Society of Sports Nutrition,” found that participants taking fish oil for six weeks improved their body composition by increasing lean muscle mass and decreasing fat mass. Omega 3 specifically EPA offers better oxygen delivery during exercise and also is key in removing lactic acid from the body
Quicker Recovery after exercise
Omega 3 specifically EPA can significantly reduce the time required for fatigued muscles to recover after exercise. They do this by helping the conversion of lactic acid to water and carbon dioxide. Omega 3 ’s are part of all cell membranes where they act as structural components and also maintain the fluidity of the cell. They are involved with the movement of substances into the cell (e.g. nutrients) and out of the cell (e.g. waste products) and also with cell to cell communication by helping to generate electrical impulses.
takeomega3 has one of the highest concentrations of EPA among the multitude of Omega 3 fish oils on the market. Indeed it is of pharmaceutical grade. Each capsule can contain as much as 10x the EPA found in other products. TakeOmega3 is also HFL tested .
takeomega3 is already being suggested as an alternative to Prozac by medical professionals– a health supplement as opposed to a pharmaceutical drug.
Eating oily fish or an equivalent can help improve the take-up of omega 3, but can never bring EPA concentrations to medically beneficial levels.
About the product
takeomega3 is an 85% pharmaceutical grade omega 3 fish oil and offers the highest concentration currently available.
takeomega3 is manufactured in one of just two MHRA (Medical Health and Regulatory Authority) licensed facilities for the sale and manufacture of omega 3 fish oil in the UK.
takeomega3 is recommended by NHS doctors and nurses and also doctors at private hospitals and clinics such as The Priory.
Each of the takeomega3 fish oil capsules contains at least 750mg EPA and 50mg DHA
takeomega3 only uses sardines and anchovies from sustainable fish stocks
As a comparison, it is worth comparing how much active ingredient is included in any rival product - it can be as low as 15%. (1000mg Omega 3 does not refer to active ingredients – it is the level of EPA and DHA that counts.)

Low levels of grey matter in brain linked to addiction

Thursday, December 1st, 2011

Gray matter in brains control center linked to ability to process reward
November 29th, 2011 in Neuroscience

In 2007 there was the first scientific evidence that clearly showed a direct co- relation between low omega 3 consumption and lower levels of grey matter in brain research showedthat raising omega-3 intake leads to structural brain changes.researchers reported that people who had lower blood levels of omega-3 fatty acids were more likely to have a negative outlook and be more impulsive.
Conversely, those with higher blood levels of omega-3s were found to be more agreeable and less likely to report mild or moderate symptoms of depression. The scientific researchers discovered that participants who had high levels of long-chain omega-3 fatty acid intake had higher volumes of grey matter in areas of the brain associated with emotional arousal and regulation — the bilateral anterior cingulate cortex, the right amygdala and the right hippocampus.This finding suggests that omega-3s may promote structural improvement in areas of the brain related to mood and emotion regulation — the same areas where grey matter is reduced in people who have mood disorders such as major depressive disorder .A study published last year found a direct correlation between the supplementation of omega 3 fatty acids and a decrease in anger and anxiety among substance abusers who had psychiatric problems.

Moving forward to 2012 we know through research that omega3 essential fatty acids pay a critical role in brain function and the following piece of research now links low grey matter with reduced levels of dopamine which has major implications with regards addiction therapy.Omega 3’s especially EPA and DHA are a major component of brain cells , they are also key to the proper function of the two brain chemical signalling systems dopamine and serotonin which have been implicated in mental health, addiction , behavioural conditions, Omega 3 fish oil also boosts levels of glutathione and anto oxidant that protects the brain against oxidadtive stress .

The more gray matter you have in the decision-making, thought-processing part of your brain, the better your ability to evaluate rewards and consequences. That may seem like an obvious conclusion, but a new study conducted at the U.S. Department of Energy’s Brookhaven National Laboratory is the first to show this link between structure and function in healthy people – and the impairment of both structure and function in people addicted to cocaine. The study appears in the Journal of Cognitive Neuroscience.

” This study documents for the first time the importance to reward processing of gray matter structural integrity in the parts of the brain’s prefrontal cortex that are involved in higher-order executive function, including self-control and decision-making,” said Muhammad Parvaz, a post-doctoral fellow at Brookhaven Lab and a co-lead author on the paper.

“Previous studies conducted at Brookhaven and elsewhere have explored the structural integrity of the prefrontal cortex in drug addiction and the functional components of reward processing, but these studies were conducted separately,” Parvaz said. “We wanted to know whether the specific function of reward processing could be ‘mapped’ onto the underlying brain structure – whether and how these two are related,” he added.

Differences in gray matter volume – the amount of brain matter made up of nerve cell bodies, as opposed to the “white matter” axons that form the connections between cells – have been observed in a range of neuropsychiatric diseases when compared with healthy states, explained Anna Konova, the other co-lead author on the paper. “We wanted to know more about what these differences mean functionally in healthy individuals and in drug-addicted individuals,” she said.

To explore this structure-function relationship, the scientists performed magnetic resonance imaging (MRI) brain scans to measure brain volume in 17 healthy people and 22 cocaine users. The scans collect structural measurements for the entire brain, and can be analyzed voxel-by-voxel – the equivalent of three-dimensional pixels – to get detailed measurements for individual brain regions.

Within a short period of the MRI scans, the scientists also used electrodes placed on the research subjects’ scalps to measure a particular electrical signal known as the P300 (an event-related potential derived from an ongoing electroencephalogram, or EEG, that is time-locked to a particular event). This specific measure can index brain activity related to reward processing. During these electrical recordings, the subjects performed a timed psychological task (pressing buttons according to a specific set of rules) with the prospect of earning varying levels of monetary reward, from no money up to 45 cents for each correct response with a total potential reward of $50.

Previous studies by the research team have shown that, in healthy subjects, the P300 signal increases in magnitude with the amount of monetary reward offered. Cocaine-addicted individuals, however, do not exhibit this differential response in the P300 measure of brain activity, even though they, like the healthy subjects, rate the task as more interesting and exciting when the potential reward is greater.

The current study extended these results by linking them for the first time with the structural measurements.

The scientists used statistical methods to look for correlations between the difference in brain activity observed in the high-reward and no-reward conditions – how much the brain’s P300 response changed with increasing reward – and the gray matter volume in various parts of the brain as measured voxel-by-voxel in the MRI scans.

In the healthy subjects, the magnitude of change in the P300 signal with increasing reward was most strongly correlated with the volume of gray matter in three regions of the prefrontal cortex.

“The higher the gray matter volume in those particular regions, the more brain activity increased for the highest monetary reward as compared to the non-reward condition,” Konova said.

The cocaine-addicted individuals had reduced gray matter volume in these regions compared with the healthy subjects, and no detectable differences between the reward conditions in the P300 measure of brain activity. There were also no significant correlations between the former and latter – structure and function measures – in the cocaine-addicted subjects.

” These findings suggest that impaired reward processing may be attributed to deficits in the structural integrity of the brain, particularly in prefrontal cortical regions implicated in higher order cognitive and emotional function,” Parvaz said. “This study therefore validates the use of the structural measures obtained by MRI as indicative of functional deficits.”

The implications are important for understanding the potential loss of control and disadvantageous decision-making that can occur in people suffering from drug addiction, Konova explained: “These structure-function deficits may translate into dysfunctional behaviors in the real world. Specifically, impaired ability to compare rewards, and reduced gray matter in the prefrontal cortex, may culminate in the compromised ability to experience pleasure and to control behavior, especially in high-risk situations – for example, when craving or under stress – leading individuals to use drugs despite catastrophic consequences.”

The authors acknowledge that there are still questions about whether these changes in brain structure and function are a cause or a consequence of addiction. But the use of multimodal imaging techniques, as illustrated by this study, may open new ways to address these and other questions relevant to understanding human motivation in both health and disease states, with particular relevance to treating dr

Omega 3 EPA the key omega3 to tackle obesity and type 2 diabetes

Saturday, October 8th, 2011

A major risk factor for cardiovascular disease, type 2 diabetes
and other pro inflammatory life-threatening conditions is the current obesity epidemic which is endemic in developed nations such as United States , United Kingdom , UAE where it’s fueled in large part by excessive consumption of a fat-rich “Western style diet.” The main issue is the increase consumption of saturated fats which are pro inflammatory ie animal fats , sunflower oil , corn oil etc Animal-derived saturated fats like lard and butter are strongly linked to adverse health effects, but unsaturated and polyunsaturated fats from plants and cold-water fish like salmon and mackerel are not. In fact, eating oily fish which is rich in omega3 especially EPA produces beneficial health effects and can reduce the risk of cardiovascular disease and diabetes
For biomedical investigators, the enduring question has been why saturated and unsaturated fatty acids produce such diametrically opposed health effects. Now, in a paper published in the Sept. 30 issue of the journal Cell, researchers at the University of California San Diego School of Medicine and colleagues offer an explanation, and a framework that could lead to dietary supplements designed to treat obesity at the molecular level.

“These findings not only explain the long-standing enigma regarding the differential health effects of saturated and unsaturated fatty acids,” said senior author Michael Karin, PhD, Distinguished Professor of Pharmacology in UC San Diego’s Laboratory of Gene Regulation and Signal Transduction, “they also provide improved tools and a mechanistic framework for the potential development of dietary supplements to treat obesity, estimated to be worth billions of dollars per year.”

Senior author Karin, first author Ryan G. Holzer, PhD, formerly a graduate student in Karin’s lab and now at the Mayo Clinic, and colleagues began with the observation that saturated fatty acids, such as palmitic acid, are potent activators of Jun kinases (JNK), key regulatory molecules implicated in the development of type 2 diabetes, insulin resistance, obesity and atherosclerosis. However, unsaturated fatty acids such as palmitoleic acid (POA) and eicosapentaenoic acid (EPA) not only do not activate JNK, but actually block JNK activation by palmitic acid.

Palmitic acid and POA differ in molecular structure by the presence of a single unsaturated bond (the absence of two hydrogen atoms) in POA. Cellular membrane fluidity is decreased upon incorporation of saturated fatty acids, which possess rigid hydrocarbon tails, but increased by the incorporation of unsaturated fatty acids with “bent” hydrocarbon tails.

Postulating that the membrane is the only cellular structure that can discriminate between all of these fatty acids, the scientists searched for membrane-associated protein kinases that could account for the differential effects on JNK activity. They ultimately identified c-Src, a membrane-associated tyrosine kinase, as the molecule responsible for activation of JNK by palmitic acid and other saturated fatty acids. They also discovered that saturated fatty acids “push” c-Src into membrane sub-domains of reduced fluidity and increased rigidity, where it accumulates in an activated form that eventually leads to JNK activation.

By contrast, POA and EPA prevent these changes in the membrane distribution of c-Src and — by blocking c-Src aggregation — they inhibit its activation by saturated fatty acids.

Most of the research was conducted using cultured cells (fibroblasts) treated with individual or combined fatty acids, but the scientists also fed mice a high-fat diet (in which 60 percent of the calories were fat-derived) and reported similar c-Src accumulation within membrane subdomains of increased rigidity and JNK activation.

Currently, polyunsaturated fatty acids, such as EPA and structurally-related omega-3 fatty acids are used in the treatment of hyperlipidemia (high blood cholesterol levels) and may be effective in the treatment or prevention of type 2 diabetes. Karin said understanding how EPA works could lead to the identification of even more potent EPA-like molecules.

Funding for this research came from the National Institutes of Health, the Superfund Basic Research Program and the American Diabetes Association.

Co-authors of the paper are Eek-Joong Park, Ning Li, Helen Tran, Monica Chen and Crystal Choi, Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, UC San Diego; and Giovanni Solinas, Laboratory of Metabolic Stress Biology, Department of Medicine, Physiology, University of Fribourg, Switzerlan

Consumption Of Omega-3 essential Fatty acid fish oils Decrease Homocysteine Levels In Diabetic Patients

Friday, July 29th, 2011

Consumption Of Omega-3 FAs Decrease Homocysteine Levels In Diabetic Patients
Pooya S, Jalali MD, Jazayery AD, et al. The efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patients. Nutr Metab Cardiovasc Dis. 2009;18.
BACKGROUND AND AIMS: Cardiovascular diseases are the major cause of mortality among diabetic patients. The concentration of malondialdehyde (MDA) and homocysteine is believed to play a role in cardiovascular diseases. Omega-3 fatty acid supplementation could be effective in some diabetes complications and in the control of the glycemic index. However, it may increase lipid peroxidation. The objective of this study was to determine the effect of omega-3 fatty acids on the concentration of homocysteine and MDA in diabetic patients.

METHODS AND RESULTS: A randomized double-blind, placebo-controlled clinical trial was conducted on 81 patients with type 2 diabetes. The patients were randomly assigned to either the treatment or control groups. Each subject received three capsules of omega-3 fatty acids or a placebo every day for a period of 2months. The two groups were similar in terms of body mass index and food intake. At the beginning of the study and after 2months of supplementation their levels of HbA(1)c, homocysteine, MDA, C-reactive protein (CRP), total cholesterol, LDL-cholesterol and fasting blood sugar (FBS) were determined. Due to omega-3 fatty acid supplementation, homocysteine was changed significantly in both treatment and control groups up to -3.10mumol/L and 0.10mumol/L respectively, and HbA(1)c decreased by 0.75% in the treatment group and increased by 0.26% in the control group. However, the changes in fasting blood sugar (FBS), malondialdehyde (MDA), C-reactive protein (CRP), total cholesterol and LDL-cholesterol levels were not significant.

CONCLUSION: The consumption of omega-3 fatty acid supplements (3g/day) for 2months decreases the levels of homocysteine in diabetic patients with no change in FBS, MDA and CRP levels.

Omega 3 fish oil EPA linked to reduce incidence of endometriosis

Sunday, July 17th, 2011
The study — which is the largest to have investigated the link between diet and endometriosis risk and the first prospective study to identify a modifiable risk factor for the condition — found that while the total amount of fat in the diet did not matter, the type of fat did. Women who ate the highest amount of long-chain Omega-3 fatty acids were 22% less likely to be diagnosed with endometriosis than those who ate the least and that those who ate the most trans fats had a 48% increased risk, compared with those who ate the least.
The findings from 70,709 American nurses followed for 12 years, published online in Europe’s leading reproductive medicine journal Human Reproduction, not only suggest that diet may be important in the development of endometriosis, but they also provide more evidence that a low fat diet is not necessarily the healthiest and further bolster the case for eliminating trans fats from the food supply, said the study’s leader, Dr. Stacey Missmer, an assistant professor of obstetrics, gynaecology and reproductive biology at Brigham and Women’s Hospital and Harvard Medical School in Boston, Massachusetts, USA.
“Millions of women worldwide suffer from endometriosis. Many women have been searching for something they can actually do for themselves, or their daughters, to reduce the risk of developing the disease, and these findings suggest that dietary changes may be something they can do. The results need to be confirmed by further research, but this study gives us a strong indication that we’re on the right track in identifying food rich in Omega-3 oils as protective for endometriosis and trans fats as detrimental,” Dr. Missmer added.
What is endometriosis  What are symptoms of endometrioisis
Endometriosis occurs when pieces of the womb lining, or endometrium, is found outside the womb. This tissue behaves in the same way as it does in the womb — growing during the menstrual cycle in response to oestrogen in anticipation of an egg being fertilized and shedding as blood when there’s no pregnancy. However, when it grows outside the womb, it is trapped and cannot leave the body as menstruation. Some women experience no symptoms, but for many it is very incapacitating, causing severe pain. The tissue can also stick to other organs, sometimes leading to infertility. It afflicts about 10% of women. The cause is poorly understood and there is no cure. Symptoms are traditionally treated with pain medication, hormone drugs or surgery.
In the study, the researchers collected information from 1989 to 2001 on 70,709 women enrolled in the U.S. Nurses Health Study cohort. They used three food-frequency questionnaires spaced at four-year intervals to record the women’s usual dietary habits over the preceding year. They categorized consumption of the various types of dietary fat into five levels and related that information to later confirmed diagnoses of endometriosis. A total of 1,199 women were diagnosed with the disease by the end of the study. The results were adjusted to eliminate any influence on the findings from factors such as total calorie intake, body mass index, number of children borne and race.
Long-chain Omega-3 fatty acids are found mostly in oily fish. They have been linked to reduced heart disease risk. In the study, the highest contributor was mayonnaise and full-fat salad dressing, followed by fatty fish such as tuna, salmon and mackerel.
Trans fats are artificially produced through hydrogenation, which turns liquid vegetable oil into solid fat. Used in thousands of processed foods, from snacks to ready-meals, they have already been linked to increased heart disease risk. Some countries and municipalities have banned them. The major sources of trans fats in this study were fried restaurant foods, margarine and crackers.
“Women tend to go to the Internet in particular to look for something they can do. The majority of the dietary recommendations they find there are the ones prescribed for heart health, but until now, those had not been evaluated specifically for endometriosis,” Dr. Missmer said. “This gives them information that is more tailored and provides evidence for another disease where it is the type of fat in the diet, rather than the total amount, that is important.”
Besides confirming the finding, a next step could be to investigate whether dietary intervention that reduces trans fats and increases Omega-3 oils can alleviate symptoms in women who already have endometriosis, Dr. Missmer added.
The U.S. National Institutes of Health funded the study.
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