Posts Tagged ‘EPA strongest natural anti inflammatory’

Meta-analysis of the effects of omega 3 fish oil eicosapentaenoic acid (EPA) in clinical trials in depression.

Wednesday, October 5th, 2011

J Clin Psychiatry. 2011 Sep 6.
Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression.
Sublette ME, Ellis SP, Geant AL, Mann JJ.
Source
New York State Psychiatric Institute, 1051 Riverside Drive, Unit 42, New York, NY, USA. 10032 es2316@columbia.edu.
Abstract
OBJECTIVE:
Randomized trials of omega-3 polyunsaturated fatty acid (PUFA) treatment for depression have differed in outcome. Recent meta-analyses ascribe discrepancies to differential effects of eicosapentaenoic acid (EPA) versus docosahexaenoic acid (DHA) and to diagnostic heterogeneity. This meta-analysis tests the hypothesis that EPA is the effective component in PUFA treatment of major depressive episodes.

DATA SOURCES:
PubMed/MeSH was searched for studies published in English from 1960 through June 2010 using the terms fish oils (MeSH) AND (depressive disorder [MeSH] OR bipolar depression) AND randomized controlled trial (publication type). The search was supplemented by manual bibliography review and examination of relevant review articles.

STUDY SELECTION:
The search yielded 15 trials involving 916 participants. Studies were included if they had a prospective, randomized, double-blinded, placebo-controlled study design; if depressive episode was the primary complaint (with or without comorbid medical conditions); if omega-3 PUFA supplements were administered; and if appropriate outcome measures were used to assess depressed mood.

DATA EXTRACTION:
Extracted data included study design, sample sizes, doses and percentages of EPA and DHA, mean ages, baseline and endpoint depression ratings and standard deviations for PUFA and placebo groups, and P values. The clinical outcome of interest was the standardized mean difference in the change from baseline to endpoint scores on a depression rating scale in subjects taking PUFA supplements versus subjects taking placebo.

DATA SYNTHESIS:
In a mixed-effect model, percentage of EPA in the supplements was the fixed-effect predictor, dichotomized into 2 groups: EPA < 60% or EPA ≥ 60% of the total EPA + DHA. Secondary analyses explored the relevance of treatment duration, age, and EPA dose.

RESULTS:
Supplements with EPA ≥ 60% showed benefit on standardized mean depression scores (effect size = 0.532; 95% CI, 0.277-0.733; t = 4.195; P < .001) versus supplements with EPA < 60% (effect size = -0.026; 95% CI, -0.200 to 0.148; t = -0.316; P = .756), with negligible contribution of random effects or heteroscedasticity and with no effects of treatment duration or age. Supplements with EPA < 60% were ineffective. Exploratory analyses supported a nonlinear model, with improvement determined by the dose of EPA in excess of DHA, within the range of 200 to 2,200 mg/d of EPA.

CONCLUSIONS:
Supplements containing EPA ≥ 60% of total EPA + DHA, in a dose range of 200 to 2,200 mg/d of EPA in excess of DHA, were effective against primary depression. Translational studies are needed to determine the mechanisms of EPA’s therapeutic benefit.

Omega 3 Fish Oil benefits help prevent muscle loss in breast cancer and protects immune system

Tuesday, April 12th, 2011

Fish oil supplements may help prevent muscle loss in breast cancer survivors and help them ward off other chronic diseases, new research from Australia suggests.The study suggests there are clear benefits fish oil supplementation.

Loss of muscle mass shortly after cancer treatment is a common problem for breast cancer survivors.

The problem may be partly due to the presence of chronic inflammation, which causes a breakdown in muscle tissue.

But fish oils interfere with inflammation, thereby reducing its effect.

University of Queensland researcher Cameron McDonald says exercise is effective in rebuilding lost muscle but it’s often hard to maintain over time.

He says muscle loss exposes survivors to the prospect of earlier onset, or exacerbated, obesity-related chronic diseases such as cardiovascular disease and diabetes.

“If fish oil supplementation is effective in preventing muscle loss before it occurs, or even more effective when used in conjunction with exercise, it could significantly decrease the risk of survivors developing a chronic disease,” the PhD student says.

Research is still in its early stages and clinical trials are set to start later in the year.

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