Posts Tagged ‘dementia’

Omega-3 fatty acid EPA cognitive decline: modulation by ApoEε4 allele and depression.

Sunday, October 16th, 2011

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Omega-3 fatty acids and cognitive decline: modulation by ApoEε4 allele and depression.
Samieri C, Féart C, Proust-Lima C, Peuchant E, Dartigues JF, Amieva H, Barberger-Gateau P.
Source

INSERM, U897, Department of Nutritional Epidemiology, Bordeaux, F-33076, France; University Victor Segalen Bordeaux 2, ISPED, 146 Rue Léo Saignat, Bordeaux, 33076, France.
Abstract

Long-chain omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may slow cognitive decline. The ε4 allele of the ApolipoproteinE (ApoE), the main genetic risk factor for Alzheimer’s disease, and depressive symptoms, which are frequently associated with cognitive impairment in older persons, may modify this relationship. We estimated the associations between EPA and DHA plasma levels and subsequent cognitive decline over 7 years, taking into account ApoE-ε4 status and depressive symptoms, in a prospective population-based cohort. Participants (≥ 65 years, n = 1,228 nondemented at baseline) were evaluated at least once over three follow-up visits using four cognitive tests. Plasma EPA was associated with slower decline on Benton Visual Retention Test (BVRT) performances in ApoE-ε4 carriers, or in subjects with high depressive symptoms at baseline. Plasma DHA was associated with slower decline on BVRT performances in ApoE-ε4 carriers only. EPA and DHA may contribute to delaying decline in visual working memory in ApoE-ε4 carriers. In older depressed subjects, EPA, but not DHA, may slow cognitive decline.

A 20%-30% decrease in developing dementia by increasing intake of essential fatty acids omega 3 EPA and DHA

Friday, July 22nd, 2011

A diet rich in EPA and DHA omega-3 fatty acids may lower the risk of developing dementia researchers report.TakeOmega3 offers the highest concentration of the essential fatty acid EPA which is the most powerful natural anti inflammatory and DHA . It offers the highest concentration currently available with 750mg EPA and 50 mg DHA per capsule an 85% concentrate, no omega3 product has higher concentrations and it is made entirely in the UK.

In a study of more than 2,000 older women and men followed for nearly five years, the more omega-3-rich oily fish they ate, the lower their risk of developing dementia.

The researchers looked specifically at the omega-3 fatty acids DHA (docosahexaenoic acid) and EPA (eiosapentaenoic acid), found in salmon, sardines, tuna, halibut, and mackerel.

Foods like meat and dairy products that are packed with saturated fatty acids, particularly palmitic acid, on the other hand, were liked to an increased risk of dementia, says researcher Deborah Gustafson, PhD, of the University of Gothenburg’s Institute for Neuroscience and Physiology, in Sweden. She is a visiting scientist at State University of New York-Downstate Medical Center in Brooklyn, N.Y.

The study doesn’t prove cause and effect, only that there is an association between different types of fatty acids and dementia.

Nevertheless, “it seems pretty clear that if you’re picking a diet to prevent Alzheimers disease with the knowledge we have today, you would pick a diet rich in fish, fruits, and vegetables and low in [saturated] fat,” William Thies, PhD, scientific director of the Alzheimer’s Association, tells WebMD. He was not involved with the study.

About 5.4 million Americans have Alzheimer’s disease, which accounts for 60% to 80% of cases of dementia.

The findings were presented here at the Alzheimer’s Association International Conference.

Omega-3s and Dementia Risk

The researchers followed 2,363 women and men aged 65 and older participating in a larger aging study. None had dementia at the start of the study.

All filled out a 61-item questionnaire that asked what foods they ate, how much, and how often. Using nutritional charts, the researchers then estimated intake of fatty acids, including EPA, DHA, palmitic acid, and stearic acid.

Neurological exams were given every 18 months. Over a period of four and one-half years, 406 of the participants were diagnosed with dementia.

Results showed that increasing intakes of EPA and DHA were associated with a 20% to 30% lower risk for dementia. Increasing intakes of palmitic acid was associated with higher dementia risk. There was no link between other types of fatty acids and dementia.

The analysis took into account other risk factors for dementia, including age, sex, race, education, and other medical conditions.

The researchers could not take into account every risk factor for dementia, Thies points out.

While the study was not designed to examine how fatty acids might affect dementia risk, Gustafson says that EPA and DHA may be protective due to their chemical and biological properties. They are building blocks for protective braincell membranes, for example, and they may calm inflammation that can damage brain cell health.

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