Posts Tagged ‘Daily Mail’

Women with low levels omega3 and high levels omega6 associated with a high risk of pre-eclampsia

Thursday, October 20th, 2011

One of the most common causes of premature birth in the UK, pre-eclampsia affects 70,000 British women every year.

There were 42 per cent more cases  of pre eclampsia in women who had conceived using IVF, the American Society for Reproductive Medicine’s annual conference  heard Women who undergo IVF are often older and as a result may have an increased risk of other health problems . The general population in UK has a diet high in the pro inflammatory omega6 ie sunflower oil and low in omega3 ie oily fish . In order to address this it maybe beneficial to eat more oily fish at least 2-3 times a week ie salmon , mackerel , sardines or take high concentrate omega3 supplement which is high in active ingredients EPA and DHA such as TakeOmega3 which offers the highest concentration globally

Preeclampsia is a systemic disease characterized by diffuse endothelial dysfunction, increased peripheral vascular resistance, coagulation abnormalities, antioxidant deficiency, persistent elevations of maternal leukocyte-derived cytokines, and hyperlipidemia. Fish oil, rich in omega-3 polyunsaturated fatty acids, is known to reduce fasting and postprandial triglycerides and to decrease platelet and leukocyte reactivity; it may also decrease blood pressure. Additionally, omega-3 fatty acids may beneficially influence vessel wall characteristics and blood rheology. In light of the potential beneficial effects of dietary omega-3 fatty acids, we conducted a cross-sectional case-control study to examine the hypothesized exposure-effect relation between maternal dietary intake of marine omega-3 fatty acids and risk of preeclampsia. We measured polyunsaturated fatty acids in erythrocytes obtained from 22 preeclamptic women and 40 normotensive women; we measured polyunsaturated fatty acids as the percentage of total fatty acids from gas chromatography. We employed logistic regression procedures to estimate odds ratios (ORs) and 95% confidence intervals (CIs). After adjusting for confounders, women with the lowest levels of omega-3 fatty acids were 7.6 times more likely to have had their pregnancies complicated by preeclampsia as compared with those women with the highest levels of omega-3 fatty acids (95% CI = 1.4-40.6). A 15% increase in the ratio of omega-3 to omega-6 fatty acids was associated with a 46% reduction in risk of preeclampsia (OR = 0.54; 95% CI = 0.41-0.72). Low erythrocyte levels of omega-3 fatty acids and high levels of some omega-6 fatty acids, particularly arachidonic acid, appear to be associated with an increased risk of preeclampsia.Women

Omega-3 fatty acids in maternal erythrocytes and risk of preeclampsia.
Williams MA, Zingheim RW, King IB, Zebelman AM.
Center for Perinatal Studies, Swedish Medical Center/Seattle, WA 98114-0999, USA.

Omega3 EPA breakthrough fish oil benefits bowel cancer treatment and prevention

Thursday, March 31st, 2011

In todays Daily Mail an article has stated that more than three quarters of women are living in ignorance of bowel cancer , a cancer that is more prevelant than both ovarian and cervical cancer put together, The study below gives a clear indication that Omega 3 EPA may indeed be a breakthrough treatment , they recommend 2 per day of EPA , TakeOmega3 is a highly purified form of omega3 which has 750 mg EPA per capsule so the patient would be required to take between 2-3 capsules per day of this product .

Diabetes: People with diabetes have a 30% to 40% increased chance of getting colorectal cancer. They also tend to have a higher death rate from this cancer.

A purified form of omega 3 EPA cuts the number and size of precancerous bowel growths (polyps) in people whose genetic make-up predisposes them to bowel cancer, finds research published ahead of print in the journal Gut. Furthermore, this particular omega 3 (eicosapentaenoic acid or EPA) seems to be as effective as the prescription medicine used to treat familial bowel polyps, but without the associated cardiovascular side effects.
The researchers base their findings on 55 patients, all of whom had the inherited genetic mutation that prompts the development of precancerous polyps in the bowel — known as familial adenomatous polyposis, or FAP for short.
People with FAP are at significantly increased risk of developing bowel cancer and require surgery to remove large sections of their bowel. Subsequently, some also need regular monitoring. All 55 patients had previously undergone surgery and were being monitored by endoscopy — a procedure involving a camera on the end of a flexible tube passed through the rectum.
Twenty eight of the patients were randomly assigned to six months of treatment with 2 g daily of a new highly purified form of the omega 3 polyunsaturated fatty acid (PUFA) EPA. The other 27 were given the same amount of a dummy treatment (placebo).
. Dietary omega 3 PUFA mainly comes from oily fish, such as salmon, mackerel, and herring.
An assessment of the number and size of polyps at the beginning and end of the six month study period revealed significant differences between the two groups of patients. The number of polyps increased by almost 10% among those treated with the placebo, but fell by more than 12% among those treated with the EPA capsules, representing a difference of almost 22.5%.
This was still clinically significant, even after taking account of influential factors, such as age and sex.
Similarly, polyp size increased by more than 17% among those in the placebo group but fell by more than 12.5% in those taking the EPA capsules, representing a difference of just under 30%.
The authors note that the effects of EPA were similar to those produced by celecoxib, which is used to help curb the growth of new and existing polyps in patients with FAP.
The use of celecoxib has been associated with harmful cardiovascular side effects in older patients. In this study, EPA produced few side effects and these were no more common than those produced by the placebo. This formulation of omega 3 might also help to prevent bowel cancer in people with the common non-familial form of bowel polyps, suggest the authors. As omega 3 PUFAs in general are safe and even good for cardiovascular health, Take Omega 3 EPA could be especially suitable for older patients at risk of both bowel cancer and heart disease, they say.

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