Posts Tagged ‘cancer and omega3’

Omega 3 Fish Oil EPA , DHA Marine-derived n−3 (omega-3) PUFAs may reduce risk of developing colorectal / bowel cancer 3 Cancer

Saturday, February 18th, 2012

Background: Marine-derived n−3 (omega-3) PUFAs may reduce risk of developing colorectal cancer; however, few studies have investigated the association of n−3 PUFA intakes on colorectal polyp risk.

Objective: The objective of this study was to examine the associations of dietary PUFA intake on risk of colorectal adenomatous and hyperplastic polyps.

Design: This was a colonoscopy-based case-control study that included 3166 polyp-free control subjects, 1597 adenomatous polyp cases, and 544 hyperplastic polyp cases. Dietary PUFA intake was calculated from food-frequency questionnaires and tested for association by using unconditional logistic regression. The urinary prostaglandin E2 metabolite, which is a biomarker of prostaglandin E2 production, was measured in 896 participants by using liquid chromatography and tandem mass spectrometry.

Results: n−6 PUFAs were not associated with adenomatous or hyperplastic polyps in either men or women. Marine-derived n−3 PUFAs were associated with reduced risk of colorectal adenomas in women only, with an adjusted OR of 0.67 (95% CI: 0.47, 0.97) for the highest quintile of intake compared with the lowest quintile of intake (P-trend = 0.01). Dietary intake of α-linolenic acid was associated with an increased risk of hyperplastic polyps in men (P-trend = 0.03), which was not seen in women. In women, but not in men, dietary intake of marine-derived n−3 PUFAs was negatively correlated with urinary prostaglandin E2 production (r = −0.18; P = 0.002).

Conclusion: Higher intakes of marine-derived n−3 PUFAs / omega3 from fish oil are associated with lower risk of adenomatous polyps in women, and the association may be mediated in part through a reduction in the production of prostaglandin E2. This trial was registered at clinicaltrials.gov as NCT00625066.

Dietary intake of PUFAs and colorectal polyp risk1,2,3,4
Harvey J Murff, Martha J Shrubsole, Qiuyin Cai, Walter E Smalley, Qi Dai, Ginger L Milne, Reid M Ness, and Wei Zheng

Supplementation with omega 3 fish oil increases first-line chemotherapy efficacy in patients

Thursday, July 28th, 2011

BACKGROUND:
Palliative chemotherapy is aimed at increasing survival and palliating symptoms. However, the response rate to first-line chemotherapy in patients with nonsmall cell lung cancer (NSCLC) is less than 30%. Experimental studies have shown that supplementation with omega 3  fish oil (FO) can increase chemotherapy efficacy without negatively affecting nontarget tissue. This study evaluated whether the combination of omega3 and fish oil and chemotherapy (carboplatin with vinorelbine or gemcitabine) provided a benefit over standard of care (SOC) on response rate and clinical benefit from chemotherapy in patients with advanced NSCLC.

METHODS:
Forty-six patients completed the study, n = 31 in the SOC group and n = 15 in the Omega 3 Fish oil  group (2.5 g EPA + DHA/day). Response to chemotherapy was determined by clinical examination and imaging. Response rate was defined as the sum of complete response plus partial response, and clinical benefit was defined as the sum of complete response, partial response, and stable disease divided by the number of patients. Toxicities were graded by a nurse before each chemotherapy cycle. Survival was calculated 1 year after study enrollment.

RESULTS:
Patients in the omega 3 fish oil group had an increased response rate and greater clinical benefit compared with the SOC group (60.0% vs 25.8%, P = .008; 80.0% vs 41.9%, P = .02, respectively). The incidence of dose-limiting toxicity did not differ between groups (P = .46). One-year survival tended to be greater in the FO group (60.0% vs 38.7%; P = .15).

CONCLUSIONS:
Compared with SOC, supplementation with omega 3 fish oil  results in increased chemotherapy efficacy without affecting the toxicity profile and may contribute to increased survival. Cancer 2011;. © 2011 American Cancer Society.

Copyright © 2011 American Cancer Society.

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