Posts Tagged ‘breast cancer’

High strength Omega3 appears to inhibit breast cancer cell growth

Wednesday, January 16th, 2013

Although evidence has shown the regulating effect of n-3 poly-unsaturated fatty acid (n-3 PUFA) marine sourced omega3 fish oil on cell signaling transduction, it remains unknown whether n-3 PUFA treatment modulates estrogen signaling.

The current study showed that docosahexaenoic acid (DHA, C22:6), eicosapentaenoic acid (EPA, C20:5) shifted the pro-survival and proliferative effect of estrogen to a pro-apoptotic effect in human breast cancer (BCa) MCF-7 and T47D cells. 17 β-estradiol (E2) enhanced the inhibitory effect of n-3 PUFAs on BCa cell growth. The IC50 of DHA or EPA in MCF-7 cells decreased when combined with E2 (10 nM) treatment (from 173 µM for DHA only to 113 µM for DHA+E2, and from 187 µm for EPA only to 130 µm for EPA+E2). E2 also augmented apoptosis in n-3 PUFA-treated BCa cells. In contrast, in cells treated with stearic acid (SA, C18:0) as well as cells not treated with fatty acid, E2 promoted breast cancer cell growth. Classical (nuclear) estrogen receptors may not be involved in the pro-apoptotic effects of E2 on the n-3 PUFA-treated BCa cells because ERα agonist failed to elicit, and ERα knockdown failed to block E2 pro-apoptotic effects. Subsequent studies reveal that G protein coupled estrogen receptor 1 (GPER1) may mediate the pro-apoptotic effect of estrogen. N-3 PUFA treatment initiated the pro-apoptotic signaling of estrogen by increasing GPER1-cAMP-PKA signaling response, and blunting EGFR, Erk 1/2, and AKT activity.

These findings may not only provide the evidence to link n-3 PUFAs omega 3 biologic effects and the pro-apoptotic signaling of estrogen in breast cancer cells, but also shed new insight into the potential application of n-3 PUFAs in Breast Cancer treatment.

Omega-3 fish oil As Possible Therapeutic Agent In Breast & Prostate Cancers

Monday, November 7th, 2011

Omega-3FA As Possible Therapeutic Agents In Breast & Prostate Cancers

Brown I, Wahle KW, Cascio MG, et al. Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids (fish oil ) in different human prostate and breast cancer cell lines. Prostaglandins Leukot Essent Fatty Acids. 2011 Oct 11.

Omega-3  fatty acids (fish oil ) inhibit breast and prostate cancer cell growth.

We previously showed that N-acylethanolamine derivatives of n-3 (n-3-NAE) are endocannabinoids, which regulate cancer cell proliferation. These n-3-NAE are synthesised in certain cells/tissues, after supplementing with omega 3 essential fatty acids found in fish oil , however, no one has assessed whether and to what extent this occurs in cancer cells.

We determined levels of endogenous n-3-NAEs in hormone sensitive and insensitive prostate and breast cancer cells and subsequent effects on other endocannabinoids (anandamide and 2-arachidonoylglycerol), before and after supplementing with DHA and EPA fatty acids which are the active ingredient of fish oil , using HPLC tandem mass spectrometry.

This is the first study reporting that omega 3 -NAEs are synthesised from their parent omega 3  fatty acids in cancer cells, regardless of tumour type, hormone status or the presence of fatty acid amide hydrolase.

This could have important implications for the use of omega 3  fatty acids ( fish oil ) as therapeutic agents in breast and prostate cancers expressing cannabinoid receptors.

Omega 3 EPA & DHA Fatty Acids to Reduce Breast Cancer Risk in Offspring,

Friday, July 22nd, 2011

MU professor to present poster on effects of diet on breast cancer during Orlando’s Era of Hope Conference

HUNTINGTON, W.Va. – Dr. Philippe T. Georgel, a professor of biological sciences and director of the Cell Differentiation and Development Center at Marshall University, will present a poster on the effects of diet on breast cancer at the Era of Hope 2011 Conference in Orlando, Fla.

The Era of Hope Conference provides a forum for scientists and clinicians from a variety of disciplines to join breast cancer survivors and advocates in learning about the advances made by the Department of Defense Breast Cancer Research Program (BCRP) awardees, to challenge paradigms and push boundaries, and to identify innovative, high-impact approaches for future research.

This year’s conference is Tuesday, Aug. 2, through Friday, Aug. 5, at the Orlando World Center Marriott. The Era of Hope Conference is expected to attract more than 1,600 BCRP awardees, survivors and invited speakers.

Georgel’s abstract, done in collaboration with Dr. Elaine Hardman and titled Maternal Consumption of Omega 3 Fatty Acids to Reduce Breast Cancer Risk in Offspring, was chosen for the conference by the Science Applications International Corporation (SAIC).

The research project investigates the ability of a maternal diet rich in omega 3 fatty acids (found in fish oil  to reduce the incidence of breast cancer and to limit growth of malignant mammary tumors in the female offspring.

The mechanism involved appears to be linked to long-term changes in gene expression mediated by epigenetic events (regulatory events that do not involve DNA mutations).

“The DOD ‘Era of Hope’ selection committee picks projects they believe have a good chance to generate potential applications in the future in terms of prevention of breast cancer,” Georgel said. “This type of study provides a window to the multiple long-term positive effects associated with a balanced diet, not only for the individuals but also for their offspring.”

Breast Cancer now affecting one in eight women can takeomega3 help prevent this disease ?

Friday, February 4th, 2011

This shocking statistic is believed to be a result of the way we now live our lives . Alcohol , lack of exercise , stress and dietary factors are all believed to contribute to this . Can omega 3 play a part in preventing women getting breast cancer ? What can women do to help reduce the risk of getting breast cancer ? These will perhaps be the questions that most women not only in UK but globally as breast cancer is a true global disease. The first study of its kind has revealed that postmenopausal women who took the omega 3 supplements reduced risk by a third.

The research, which involved 35,000 women and took six years to complete, has caused such excitement among experts that they are calling for larger and more detailed studies to urgently be carried out. Could the very action of take a high grade omega 3 supplement such as takeomega3 help in some way to prevent breast cancer ? Takeomega 3 has the highest levels of EPA currently available of any omega3 supplement with 750mg per capsule as a result it is an extremely potent anti inflammatory formulation.

They hope that it may be possible to use fish oils as a way to help women slash their risk of suffering from breast tumours.

Fish Oil contains high levels of fatty acids that can reduce inflammation. Studies have already suggested they may boost brain cells, keep eyes healthy and possibly protect against ageing.

But other studies have dismissed these claims, saying the evidence is still not there. The latest study, by a respected team in America, is the first to actively monitor women who take fish oils and see how many develop breast cancer

The team also looked at whether other supplements like St John’s Wort, soy and ginkgo biloba had any affect on the risk of tumours. All of the women in the study were between 50 and 76 and had been through the menopause.

They were asked if they had taken fish oils before or were taking them at the start of the study and how often they took them.

The team, whose study is published in the Journal of Cancer, Epidemiology, Biomarkers and Prevention, found 83 per cent took fish oils at least four times a week and 60 per cent daily. During the following six years, 880 suffered from breast cancer.

The data revealed that those who took fish oils at the start of the study had a 32 per cent reduced risk of ductal breast cancer, the most common form of the disease which affects eight in 10 sufferers.

However, there was no reduction in risk of lobular breast cancer that affects around one in 10 sufferers. Nor was there a reduced risk of women who had taken fish oils up to a decade earlier but stopped or those who took other supplements.

The team, from the Fred Hutchinson Cancer Research Center in Seattle, said the findings were interesting but it was too early to say if the fish oil is responsible. Scientists believe fish oils might work by reducing inflammation which may prevent cells from becoming damaged and turning cancerous.

Previous studies on cells in the lab and on animals both suggest fish oils might be able to protect against cancer. Scientists are keen to find an answer because more and more people have been taking supplements for decades.

This means they have been used for long enough to gauge whether they are having a positive or negative effect on long-term health. So far British experts warn against taking multi-vitamins to protect against cancer, with some warning they may increase the risk.

But the evidence on fish oils is less clear.Dr Panagiota Mitrou, deputy head of science for the World Cancer Research Fund, said: “The findings are very interesting because it is the first time fish oil has been linked to lower breast cancer risk in this type of study.

“But as the authors suggest, because this is a single study the findings are not enough for us to be confident that women can reduce their risk of breast cancer by taking fish oil supplements. More research is now needed to find out if this is actually the case.

“There is already very strong scientific evidence about how women can reduce their breast cancer risk. In fact scientists estimate that about 40 per cent of breast cancer cases in the UK could be prevented through being physically active, maintaining a healthy weight and reducing the alcohol they drink.”

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