Posts Tagged ‘best omega3 for breast cancer’

Omega-3 fish oil is Linked To Decreased Inflammation And Decreased Fatigue in Breast Cancer

Saturday, March 17th, 2012

Omega-3 fish oil is Linked To Decreased Inflammation And Decreased Fatigue in Breast Cancer – Omega 3 active ingredient EPA is the most potent natural anti inflammatory
Alfano CM, Imayama I, Neuhouser ML, et al. Fatigue, Inflammation, and ω-3 and ω-6 Fatty Acid Intake Among Breast Cancer Survivors. J Clin Oncol. 2012 Mar 12.
PURPOSE: Evidence suggests that inflammation may drive fatigue in cancer survivors. Research in healthy populations has shown reduced inflammation with higher dietary intake of Omega 3 ω-3 polyunsaturated fatty acids (PUFAs), which could potentially reduce fatigue. This study investigated fatigue, inflammation, and intake of Omega 3 ω-3 and Omega 6 ω-6 PUFAs among breast cancer survivors.

METHODS: Six hundred thirty-three survivors (mean age, 56 years; stage I to IIIA) participating in the Health, Eating, Activity, and Lifestyle Study completed a food frequency/dietary supplement questionnaire and provided a blood sample assayed for C-reactive protein (CRP) and serum amyloid A (30 months after diagnosis) and completed the Piper Fatigue Scale and Short Form-36 (SF-36) vitality scale (39 months after diagnosis). Analysis of covariance and logistic regression models tested relationships between inflammation and fatigue, inflammation and Omega3 ω-3 and Omega 3 ω-6 PUFA intake, and PUFA intake and fatigue, controlling for three incremental levels of confounders. Fatigue was analyzed continuously (Piper scales) and dichotomously (SF-36 vitality ≤ 50).

Results: Behavioral (P = .003) and sensory (P = .001) fatigue scale scores were higher by increasing CRP tertile; relationships were attenuated after adjustment for medication use and comorbidity. Survivors with high CRP had 1.8 times greater odds of fatigue after full adjustment (P < .05). Higher intake of ω-6 relative to ω-3 PUFAs was associated with greater CRP (P = .01 after full adjustment) and greater odds of fatigue (odds ratio, 2.6 for the highest v lowest intake; P < .05).

CONCLUSION: Results link higher intake of Omega3 ω-3 PUFAs, decreased inflammation, and decreased physical aspects of fatigue. Future studies should test whether Omega3 ω-3 supplementation may reduce fatigue among significantly fatigued breast cancer survivors.

Omega3 highest concentration is found in takeomega3 which is high in the active omega3 EPA - the most potent natural anti inflammatory . TakeOmega3 is a unique pharmaceutical grade formulation manufactured in MHRA facilities in the UK . It is an 85% concentration with each capsule containing 750mg EPA and 50mg DHA.

Omega 3 Fish Oil benefits Intensifies the positive effect of Tamoxifen

Monday, April 11th, 2011

Female mice that ingested fish oil supplements with breast cancer drug tamoxifen appeared to have slowed the proliferation of their tumors, compared to rodents given corn oil with the drug, according to researchers at Fox Chase Cancer Center.

In the controlled study, the team of scientists found that the omega-3 fatty acids found in fish oil helped to slow gene expression related to tumor growth.

“If a tumor was being treated with tamoxifen, the addition of an omega-3 fatty acid diet seemed to make the tumor, at least at the molecular level, more benign and less aggressive and responsive to tamoxifen,” said lead researcher Jose Russo, M.D. TakeOmega3 due to its unique high EPA formulation with 750mg EPA per capsule and its high purity of 85% omega3 would be the ideal omega3 supplement to take alongside Tamoxifen . TakeOmega3 offers the highest concentration currently available and it is uniquely manufactured in facilities licensed by MHRA (Medical Health & Regulatory Authority) here in UK . No other omega3 supplement currently offers these benefits .

Additionally, the healthy fats appeared to curb immune responses that result in allergies and inflammation. These negative effects have been known to alter the body’s natural defense against cancer.

Next, the researchers hope to investigate how omega-3 fatty acids in a diet can affect risk of breast cancer in women.

Authors of the study noted that an estimated 200,000 women are diagnosed with the disease each year.

Breast cancer is the second most common cancer among women, with more than 200,000 women diagnosed each year. Being exposed to estrogen over a long period of time is one factor that can increase a woman’s risk of developing the disease. One way a woman can combat this risk factor is by taking the breast cancer drug tamoxifen, which interferes with the activity of estrogen. Now, researchers at Fox Chase Cancer Center have found that omega-3 fatty acids — abundant in fish — could be a safe and beneficial booster for tamoxifen therapy.

Jose Russo, MD, director of the Breast Cancer Research Laboratory at Fox Chase, is presenting the new findings at the AACR 102nd Annual Meeting 2011 on April 6.
To investigate how fish oil intensifies the effects of tamoxifen, Russo, in collaboration with a team led by Andrea Manni, MD, from Pennsylvania State University, induced mammary tumors in rats and then divided the animals into four groups. They fed the groups either a 17 percent fish oil diet, with or without tamoxifen, or a 20 percent corn oil diet, with or without tamoxifen, for eight weeks. They then analyzed gene expression patterns in the tumors. Omega-3 fatty acids produced a greater expression of genes related to cellular specialization, or differentiation — a sign of lower cancer severity — compared to corn oil. The combination of fish oil and tamoxifen reduced the expression of genes linked to tumor growth and spreading.

“The fish oil diet also boosted the expression of genes related to immune defenses against tumors, more so than did the corn oil diet. But omega-3 fatty acids simultaneously increased the expression of genes that trigger counterproductive immune responses, such as inflammation and allergic reactions, which curtail the ability of cells to fight cancer and can even promote the migration of tumor cells.

More studies are needed to fully understand the effects of fish oil on the immune system, Russo says. Meanwhile, his team is examining whether omega-3 fatty acids can prevent breast cancer in animals and testing the influence of diet on breast cancer risk in women.

Co-authors on the study include Bidinotto, L.T.; Vanegas, J.E.; Vanden Heuvel, J.P.; Lopez, R.; Santucci-Pereira, J.; Washington, S., Xu; H., Russo I.H.; El-Bayoumy, K.; and Manni, A. from Fox Chase.

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