Posts Tagged ‘best fish oil’

Omega3 Fatty acid EPA most potent omega3 for inflammation and healing in athletes Omega3 EPA accelerates ligament healing

Tuesday, July 24th, 2012

Omega3 Fatty acid EPA most potent omega3 for inflammation and healing in athletes – TakeOmega3 HFL tested
Omega3 EPA accelerates ligament healing

Ligaments are tough bands of fibrous connective tissue (mainly collagen) that link two bones together at a joint. Injuries to ligaments are notoriously slow to heal. Researchers at Purdue University now report the results of an intriguing experiment which shows that eicosapentaenoic acid (EPA – one of the acitive ingredients iin fish oil materially speeds up the healing of “wounded” ligament cells in vitro. The experiment was carried out on three cultures of animal medial collateral ligament cells. The first culture was treated with arachidonic acid (an n-6 polyunsaturated fatty acid), the second with eicosapentaenoic acid (an n-3 polyunsaturated fatty acid), and the third served as a control.
After four days the cells were analyzed to determine their fatty acid profile. The AA (arachidonic acid) treated cells were found to have an n-6 to n-3 ratio of 24.3 while the EPA (eicosapentaenoic acid) treated cells had a ratio of 1.1. This indicates that the two fatty acids were well-absorbed and incorporated into the cells. Next a “wound” was introduced into the surface layers of the cell cultures by streaking a sterile pipette across them. The rate at which ligament cells grew back into the “wound” was measured over a 72-hour period and taken as an indication of wound healing speed. Both the AA and EPA treated cultures showed a higher degree of regrowth in the wound area than did the control. However, while AA decreased the synthesis of collagen by the ligament cells, EPA markedly increased it.
The researchers conclude that dietary supplementation with omega3 fish oils specifically EPA (n-3 polyunsaturated fatty acid) could be used to improve the healing of ligament injuries by enhancing the entry of new cells into the wound area and by speeding up collagen synthesis.
Source
Hankenson, Kurt D., et al. Omega-3 fatty acids enhance ligament fibroblast collagen formation in association with changes in interleukin-6 production. Proceedings of the Society for Experimental Biology and Medicine

Omega 3 and chronic tendon disorders in athletes
Does Omega 3 have any benefit in the treatment of chronic tendon disorders ? This is a major problem amongst recreational athletes and we do get asked if taking a high dose omega 3 such as Take Omega3 which is high in the key anti – inflammatory essential fatty acid EPA and is also HFL tested would be of any help . Several years ago there was a study conducted whereby they evaluated treatment with essential fatty acids and antioxidants combined with physiotherapy.
Methods and measures
In a randomised, double-blind, placebo-controlled trial 40 volunteers active in recreational sports with chronic tendon disorders were assigned to the study. The subjects were divided in two groups, one consuming a daily dosage of essential fatty acids and antioxidants and one consuming similar placebo. Furthermore, the subjects received 16 sessions of ultrasound treatment over 32 days. Evaluation was pain scores, rated on a visual analogue scale and quantification of normal sports activity during treatment.
Results
In the treatment group there was a significant reduction of pain compared with the placebo group (P<0.001) after 32 days. There was a mean decrease in pain score of 99% in the treatment group compared with a mean decrease of 31% in the placebo group. Sport-specific activity increased by 53% in the treatment group and increased by 11% in the placebo group.
Conclusions
The results suggest beneficial effect of essential fatty acids and antioxidants in combination with physiotherapy treating chronic tendon disorders.

Omega 3 essential fatty acid EPA Reduces Inflammation
Athletes often undergo high-intensity training that increases inflammation and the risk for pain and injury. This can decrease exercise performance and the ability to recover properly. Omega-3 fatty acids fish oil specifically EPA is effective in reducing inflammation. Researcher Dr. William Smith from the University of Massachusetts found that omega-3 fatty acids decrease inflammation by diminishing the production of prostaglandin's, hormone-like substances associated with inflammation in the body. Omega 3 EPA is the most powerful natural anti inflammatory and unlike pharmaceutical anti inflammatory products there are no health risks or side effects when taking them .
Improves Body Composition

Athletes often focus on body composition, or fat to muscle ratio, in order to stay in top physical shape and maximise training and performance. In a study published in the October issue of the “Journal of the International Society of Sports Nutrition,” found that participants taking fish oil for six weeks improved their body composition by increasing lean muscle mass and decreasing fat mass. Omega 3 specifically EPA offers better oxygen delivery during exercise and also is key in removing lactic acid from the body
Quicker Recovery after exercise
Omega 3 specifically EPA can significantly reduce the time required for fatigued muscles to recover after exercise. They do this by helping the conversion of lactic acid to water and carbon dioxide. Omega 3 ’s are part of all cell membranes where they act as structural components and also maintain the fluidity of the cell. They are involved with the movement of substances into the cell (e.g. nutrients) and out of the cell (e.g. waste products) and also with cell to cell communication by helping to generate electrical impulses.
takeomega3 has one of the highest concentrations of EPA among the multitude of Omega 3 fish oils on the market. Indeed it is of pharmaceutical grade. Each capsule can contain as much as 10x the EPA found in other products. TakeOmega3 is also HFL tested .
takeomega3 is already being suggested as an alternative to Prozac by medical professionals– a health supplement as opposed to a pharmaceutical drug.
Eating oily fish or an equivalent can help improve the take-up of omega 3, but can never bring EPA concentrations to medically beneficial levels.
About the product
takeomega3 is an 85% pharmaceutical grade omega 3 fish oil and offers the highest concentration currently available.
takeomega3 is manufactured in one of just two MHRA (Medical Health and Regulatory Authority) licensed facilities for the sale and manufacture of omega 3 fish oil in the UK.
takeomega3 is recommended by NHS doctors and nurses and also doctors at private hospitals and clinics such as The Priory.
Each of the takeomega3 fish oil capsules contains at least 750mg EPA and 50mg DHA
takeomega3 only uses sardines and anchovies from sustainable fish stocks
As a comparison, it is worth comparing how much active ingredient is included in any rival product - it can be as low as 15%. (1000mg Omega 3 does not refer to active ingredients – it is the level of EPA and DHA that counts.)

BENEFICIAL EFFECT OF EICOSAPENTAENOIC ACID ON ENDOTHELIAL FUNCTION IN OLD MYOCARDIAL INFARCTION PATIENTS UNDER ADEQUATE STATIN THERAPY

Sunday, April 29th, 2012

BENEFICIAL EFFECT OF EICOSAPENTAENOIC ACID ON ENDOTHELIAL FUNCTION IN OLD MYOCARDIAL INFARCTION PATIENTS UNDER ADEQUATE STATIN THERAPY

Kentaro Toyama, Osamu Sasaki, Toshihiko Nishioka and Hiroyuki Ito
Department of cardiology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan

J Am Coll Cardiol, 2012; 59:1773, doi:10.1016/S0735-1097(12)61774-4
© 2012 by the American College of Cardiology Foundation

Eicosapentaenoic acid (EPA) is reported to augment endothelial function and improve clinical outcomes in patients with coronary artery disease. However, it is unclear whether the effect of EPA is preserved even in patients under adequate statin therapy as secondary prevention. We hypothesized that EPA could improve endothelial function in old myocardial patients (OMI) with adequate lipid-lowering treatment using statin.
Fifty-five OMI patients under statin treatment with serum LDL cholesterol levels less than 100 mg/dl were randomly assigned to receive either 1800 mg of EPA daily with statin (EPA group, n=29) or statin alone (non-EPA group, n=26). Lipid profiles and flow-mediated dilation (FMD) were assessed just before and 6 months after the randomization in both groups.

EPA group presented significant increase in plasma concentrations of EPA (p<0.001). In EPA group, LDL-cholesterol and trygliceride levels significantly decreased (p<0.05), whereas no significant change was seen in non-EPA group. FMD, which is the primary end point of this study, showed significant improvement in EPA group (2.41±1.46% to 3.18±1.82%, p=0.001), while no significant change was seen in non-EPA group (2.51±1.48% to 2.25±1.42%, p=NS). Furthermore, FMD defined as post FMD - pre FMD significantly increased in EPA group (0.77±1.17 vs –0.25±1.59, p=0.009).

EPA further improved endothelial function in old myocardial infarction patients under adequate statin therapy.

What is pharmaceutical grade omega 3 fish oil

Sunday, January 22nd, 2012

Omega3
What is Pharmaceutical Grade Omega3 Fish Oil and why is Takeomega3 different from other brands ?
Pharmaceutical Grade Fish Oil
The true definition is an oil of concentration 80% -90% omega 3 such as TakeOmega3. There are a lot of omega3 products that claim to be pharmaceutical grade when they are not . Looking on the rear label makes everything clear
The majority of omega3 products on shelf are what we define as 18/12 this means 18% EPA and 12%DHA making a total of 30% omega 3. The remaining 70% is made up of monounsaturated,polyunsaturated and saturated fats. Your body has no need for these.
18/12 products are usually advertised as “1000mg Omega3” and they will have only 30% omega3 – giving a total of 300mg omega3 split 180mg EPA and 120 DHA.
Compare that to TakeOmega3 with 750mg EPA and 50mg DHA an 85% concentrate .

Benefits of Pharmaceutical Grade Fish oil such as TakeOmega3 85% Omega3
• 80% and above Omega3
• Virtually no environmental toxins the repeated molecular distillation necessary to achieve high concentrations removes virtually all toxins and heavy metals ie mercury
• Ultra purity reduces fish odour often associated with low concentration formulations
• An easy way to get high doses of omega3 with just one or two capsules as opposed to 10 capsules of low concentration brands.
• Research has shown low concentration capsules are not as effective as single dose pharmaceutical omega3 even when taking multiple capsules.
• The Omega3 fish oils used in Clinical trials / research the majority of the time pharmaceutical grade therefore why would you choose to take a low concentration oil
• You actually feel a difference .

Osteoporosis and low bone density are common in people in the early stages of multiple sclerosis (MS), according to a new study published in the Neurology®, the medical journal of the American Academy of Neurology.

Saturday, July 16th, 2011

We’ve known that people who have had MS for a long time are at a greater risk of low bone density and broken bones, but we didn’t know whether this was happening soon after the onset of MS and if it was caused by factors such as their lack of exercise due to lack of mobility, or their medications or reduced vitamin D from lack of sun exposure,” said study author Stine Marit Moen, MD, of Oslo University Hospital Ulleval in Norway.

Research has shown Omega-3 fatty acids found in fish oil specifically EPA and DHA ,  are positively associated with bone mineral accrual and, thus, with peak BMD in young men.” Higher bone density in youth can decrease the chances of brittle bones and osteoporosis later in life.

Low vitamin D levels are associated with an increased risk of MS. Low vitamin D levels can lead to reduced calcium absorption and bone mineralization, or the process the body uses to turn minerals into bone structure.
“Our hypothesis was that if vitamin D exerts a major effect on the risk of MS, then the effects of low vitamin D levels on bone density would be apparent soon after the onset of MS,” Moen said.
The study involved 99 people with an average age of 37 who were recently diagnosed with MS or clinically isolated syndrome, which means they had a first episode of symptoms like those in MS but have not yet been diagnosed with the disease. All had no or minor physical disability from the disease.
The participants had bone density tests an average of 1.6 years after the first time they had any symptoms suggestive of MS. Their tests were compared to bone tests of 159 people of similar age, gender and ethnicity who did not have the disease.
A total of 51 percent of those with MS had either osteoporosis or osteopenia, compared to 37 percent of those who did not have the disease. Osteoporosis is a disease where low bone density causes the bones to become thin and brittle, making them more likely to break. Osteopenia is low bone density that is less severe than osteoporosis but puts a person at risk for osteoporosis.
The results remained the same after researchers adjusted for other factors that can affect bone density, such as smoking, alcohol use and hormone treatment.
“These results suggest that people in the early stages of MS and their doctors need to consider steps to prevent osteoporosis and maintain good bone health,” Moen said.

The presence of omega-3 fatty acids in young men is linked to “peak bone mass” or bone mineral density, according to a study published in the American Journal of Clinical Nutrition. The study found that 22-year-old men with the highest levels of omega-3 fatty acids had the greatest bone density in the body and spine two years later.

Dr. Magnus Hogstrom and colleagues from Umea University in Sweden followed 78 healthy young men from their mid-teens to early adulthood. The team measured the BMD (bone mineral density) of the total body, hip and spine at the start of the study and again when the participants were 22 and 24 years of age. The objective was to quantify a relationship between the levels of omega-3 fatty acids and bone density.

According to the journal, “The results showed that Omega-3 fatty acids,  are positively associated with bone mineral accrual and, thus, with peak BMD in young men.” Higher bone density in youth can decrease the chances of brittle bones and osteoporosis later in life.

As well as that the EPA in omega3 is one of the most potent  natural anti inflammatory as detailed in previous blogs , as a result the EPA will reduce any inflammation naturally as there is a clear relationship with osteoporosis and inflammation the EPA will target the site of inflammation and reduce it.

Although osteoporosis is often associated with women, the American Osteoporosis Foundation reports that two million American men have osteoporosis. Inadequate physical exercise, smoking and use of antacids that contain aluminum are among risk factors.

Recent research by NASA has also shown that omega3 is a key factor in preventing bone density loss during space travel and they advise that this has important implications for those at risk or suffering from osteoporosis

Omega 3 Fish Oil EPA and DHA reduce anxiety and inflammation in healthy students

Thursday, July 14th, 2011

Omega-3 Reduces Anxiety and Inflammation in Healthy Students,
A new study gauging the impact of consuming more fish oil showed a marked reduction both in inflammation and, surprisingly, in anxiety among a cohort of healthy young people.

The findings suggest that if young participants can get such improvements from specific dietary supplements, then the elderly and people at high risk for certain diseases might benefit even more.
The findings by a team of researchers at Ohio State University were just published in the journal Brain, Behavior and Immunity. It is the latest from more than three decades of research into links between psychological stress and immunity.
Omega-3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have long been considered as positive additives to the diet. Earlier research suggested that the compounds might play a role in reducing the level of cytokines in the body, compounds that promote inflammation, and perhaps even reduce depression.
Psychological stress has repeatedly been shown to increase cytokine production so the researchers wondered if increasing omega-3 might mitigate that process, reducing inflammation.
To test their theory, they turned to a familiar group of research subjects — medical students. Some of the earliest work these scientists did showed that stress from important medical school tests lowered students’ immune status.
“We hypothesized that giving some students omega-3 supplements would decrease their production of proinflammatory cytokines, compared to other students who only received a placebo,” explained Janice Kiecolt-Glaser, professor of psychology and psychiatry.
“We thought the omega-3 would reduce the stress-induced increase in cytokines that normally arose from nervousness over the tests.”
The team assembled a field of 68 first- and second-year medical students who volunteered for the clinical trial. The students were randomly divided into six groups, all of which were interviewed six times during the study. At each visit, blood samples were drawn from the students who also completed a battery of psychological surveys intended to gauge their levels of stress, anxiety or depression. The students also completed questionnaires about their diets during the previous weeks.
Half the students received omega-3 supplements while the other half were given placebo pills.
“The supplement was probably about four or five times the amount of fish oil you’d get from a daily serving of salmon, for example,” explained Martha Belury, professor of human nutrition and co-author in the study.
Part of the study, however, didn’t go according to plans.
Changes in the medical curriculum and the distribution of major tests throughout the year, rather than during a tense three-day period as was done in the past, removed much of the stress that medical students had shown in past studies.
“These students were not anxious. They weren’t really stressed. They were actually sleeping well throughout this period, so we didn’t get the stress effect we had expected,” Kiecolt-Glaser said.
But the psychological surveys clearly showed an important change in anxiety among the students: Those receiving the omega-3 showed a 20 percent reduction in anxiety compared to the placebo group.
An analysis of the of the blood samples from the medical students showed similar important results.
“We took measurements of the cytokines in the blood serum, as well as measured the productivity of cells that produced two important cytokines, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFa),” said Ron Glaser, professor of molecular virology, immunology & medical genetics and director of the Institute for Behavioral Medicine Research.
“We saw a 14 percent reduction in the amounts of IL-6 among the students receiving the omega-3.” Since the cytokines foster inflammation, “anything we can do to reduce cytokines is a big plus in dealing with the overall health of people at risk for many diseases,” he said.
While inflammation is a natural immune response that helps the body heal, it also can play a harmful role in a host of diseases ranging from arthritis to heart disease to cancer.

Omega 3 Fish Oil

Friday, June 3rd, 2011

TakeOmega3 is currently the highest concentration omega3 available and each capsule contains 750mg EPA which is the most powerful natural anti inflammatory and 50mg DHA . EPA actually produces anti inflammatory hormones

It has multiple applications in a clinical and sports setting -

This formulation lowers risk of death from heart disease, heart attack and stroke by preventing clots , decreasing inflammation in the vessels , decreasing cholesterol and stabalizing the heartbeat to prevent irregular contractions
Reduces inflammation in the body which helps conditions such as Arthritis and Inflammatory Bowel Disease , Type 2 Diabetes , Eczema and Psoriasis – EPA is now recognised as the most powerful natural anti inflammatory
Improves mood and concentration especially under stressful conditions , also speeds recovery from traumatic brain injury and recent studies have been looking at the benefits for combat aircraft pilots re improvement in cockpit skills .
Offers better oxygen delivery to the body as a result less muscle fatigue and removes carbon dioxide / lactic acid .
Research is now focusing on the fact it may help prevent osteoporosis
Research is now showing that omega 3 can be linked with a reduction risk of breast cancer , bowel/colon cancer and prostate cancer by as much as 40%
It helps prevent muscle wastage during illness , specifically with regards Cancer and aging as well being the only effective treatment with regards Cancer Malnutrition .
It improves weight loss especially around stomach area
Lowers triglycerides by 20% to 50%
lowers blood pressure
Helps improve bone mass

In athletes it improves stamina and performance , supports mental concentration and focus . Also assists in quicker recovery time after injury

Hughes Syndrome Multiple Miscarriage Antiphospholipid syndrome

Tuesday, April 19th, 2011

Hughes Syndrome is believed to be the cause of multiple miscarriage . The condition also known as Antiphospholipid syndrome was identified in the 80’s by Prof Graham Hughes. Basically the condition causes the blood to become sticky and as a result prone to clotting . Omega 3 specifically EPA is believed to have benefit to this due to its blood thinning effect  our product contains no Vitamin A or Vitamin D which are found in cod liver oil and maybe harmful during pregnancy – the advantage is that this is a completely natural effect and has none of the side effects of blood thinning medications. They also when taken along side blood thinning drugs such as aspirin clopedigrel (Plavix) and warfarin strengthen the effect so it maybe that a lower dose of pharmaceutical medication is required .

The key to successful use of omega3 as a blood thinner is to ensure that it is a high concentration product with high levels of EPA – EPA is the key anti inflammatory which is why it is so effective . Obviously you should speak with your doctor if you are currently on blood thinning medications. Unlike Cod Liver Oil our omega 3 fish oil  contains no vitamin A or D which maybe harmful during pregnancy

Omega 3 Fish Oil benefits help prevent muscle loss in breast cancer and protects immune system

Tuesday, April 12th, 2011

Fish oil supplements may help prevent muscle loss in breast cancer survivors and help them ward off other chronic diseases, new research from Australia suggests.The study suggests there are clear benefits fish oil supplementation.

Loss of muscle mass shortly after cancer treatment is a common problem for breast cancer survivors.

The problem may be partly due to the presence of chronic inflammation, which causes a breakdown in muscle tissue.

But fish oils interfere with inflammation, thereby reducing its effect.

University of Queensland researcher Cameron McDonald says exercise is effective in rebuilding lost muscle but it’s often hard to maintain over time.

He says muscle loss exposes survivors to the prospect of earlier onset, or exacerbated, obesity-related chronic diseases such as cardiovascular disease and diabetes.

“If fish oil supplementation is effective in preventing muscle loss before it occurs, or even more effective when used in conjunction with exercise, it could significantly decrease the risk of survivors developing a chronic disease,” the PhD student says.

Research is still in its early stages and clinical trials are set to start later in the year.

Depression study confirms effectiveness of EPA as anti depressant treatment

Tuesday, March 15th, 2011

The use of Omega-3 supplements is effective among patients with major depression who do not have anxiety disorders, according to a study directed by Dr. François Lespérance of the Centre de recherche du Centre hospitalier at the Université de Montréal (CRCHUM), head of CHUM’s Department of Psychiatry and a professor at the Université de MontréalThe study was published June 15 in the online Journal of Clinical Psychiatry.Take Omega3 is the ideal formulation to treat depression due to each capsule containing 750mg EPA and 50mg DHA it is an 85% concentrate which is the highest currently available.

This was the largest study ever conducted assessing Omega-3’s efficacy in treating major depression. It was carried out in conjunction with researchers from centres affiliated with the UdM’s Réseau universitaire intégré de santé (RUIS), from McGill University, Université Laval in Quebec City and Queen’s University in Kingston, Ontario.

Initial analyses failed to clearly demonstrate the effectiveness of Omega-3 for all patients taking part in the study. Other analyses, however, revealed that Omega-3 improved depression symptoms in patients diagnosed with depression unaccompanied by an anxiety disorder. Efficacy for these patients was comparable to that generally observed with conventional antidepressant treatment.

From October 2005 to January 2009, 432 male and female participants with major unipolar depression were recruited to take part in this randomized, double-blind study (neither patients nor researchers knew which capsules patients received)Some 11% of men and 16% of women in Canada will suffer from major depression at some point in their lives, making this disorder one of our society’s leading public health issues. Depression, which is now the world’s fourth leading cause of morbidity and death is expected to move up to the number two position by 2020. “Despite significant progress in neuroscience over the past two decades, depression is difficult to treat,” Dr. Lespérance noted. In view of the large number of patients who stop taking their medications in the first few months of treatment and those who refuse such treatment due to fear of stigmatization or side effects, it comes as no surprise that a large number of patients suffering from major depression use alternative treatments offered outside the healthcare system. “Many of these treatments have not been adequately evaluated. That is why it was important to assess the efficacy of Omega-3, one of the most popular alternative approaches,” he added.

Epidemiological and neurobiological studies have suggested that a relative deficit in polyunsaturated fatty acids of the Omega-3 group may predispose individuals to psychological disorders such as depression. Further, several preliminary clinical studies based on small numbers of patients have suggested that Omega-3 supplements with high concentrations of EPA can help to reduce symptoms of depression among patients who fail to respond to an initial antidepressant treatment. These studies have not, however, convinced the entire scientific community. A broader study was needed to acquire further knowledge about the properties and efficacy of high-quality Omega-3 supplements among patients suffering from major depression.udy.

It is important to note that the study assessed use of Omega-3 for eight weeks, at doses of 1050 mg of EPA and 150 mg of DHA each day. It is currently unknown whether taking higher doses or taking supplements over a longer period would yield different results.

These encouraging results show that use of EPA is effective among patients with unipolar depression unaccompanied by an anxiety disorder. Additional research directly comparing Omega-3 with conventional antidepressants could more clearly confirm their usefulness for patients suffering from depression

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