Posts Tagged ‘benefits of fish oil’

Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain.

Saturday, July 9th, 2011

Abstract
BACKGROUND:
The use of NSAID medications is a well-established effective therapy for both acute and chronic nonspecific neck and back pain. Extreme complications, including gastric ulcers, bleeding, myocardial infarction, and even deaths, are associated with their use. An alternative treatment with fewer side effects that also reduces the inflammatory response and thereby reduces pain is believed to be omega-3 EFAs found in fish oil specifically EPA. We report our experience in a neurosurgical practice using fish oil supplements for pain relief.

METHODS:
From March to June , 250 patients who had been seen by a neurosurgeon and were found to have nonsurgical neck or back pain were asked to take a total of 1200 mg per day of omega-3 EFAs (eicosapentaenoic acid and DHA )found in fish oil supplements. A questionnaire was sent approximately 1 month after starting the supplement.

RESULTS:
Of the 250 patients, 125 returned the questionnaire at an average of 75 days on fish oil. Seventy-eight percent were taking 1200 mg and 22% were taking 2400 mg of EFAs. Fifty-nine percent discontinued to take their prescription NSAID medications for pain. Sixty percent stated that their overall pain was improved, and 60% stated that their joint pain had improved. Eighty percent stated they were satisfied with their improvement, and 88% stated they would continue to take the fish oil. There were no significant side effects reported.

CONCLUSIONS:
Our results mirror other controlled studies that compared ibuprofen and omega-3 EFAs demonstrating equivalent effect in reducing arthritic pain. omega-3 EFA fish oil supplements appear to be a safer alternative to NSAIDs for treatment of nonsurgical neck or back pain in this selective group.
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

Omega 3 fish oil may reduce depression symptoms in the elderly

Thursday, May 26th, 2011

Daily omega-3 supplements may reduce the occurrence of the symptoms of depression in elderly women, says a new study from Italy that adds to the ongoing debate over omega-3 and mood.

Statistically and clinically significant – Harry Rice, PhD

Statistically and clinically significant – Harry Rice, PhD

According to findings published in The Journal of Nutrition, Health & Aging, depressed women who received daily supplements containing 2.5 grams of omega-3 experienced significant reductions in their symptoms.

In addition, researchers from the University of Pavia also report that omega-3 supplements providing a daily EPA (eicosapentaenoic acid) dose of 1.67 grams and a daily DHA (docosahexaenoic acid) dose of 0.83 grams reported improvements in the ‘quality of life’.

“This [quality of life] observation has never been achieved before and it appears of great value from the clinical point of view, due to the importance of these aspects in the elderly population,” wrote the researchers.

“The concept of quality of life is defined as a perceived global satisfaction and satisfaction within a number of key domains, with special emphasis on well-being.

“Therefore, the amelioration of quality of life in depressed elderly patients after supplementation with omega-3 long-chain polyunsaturated fatty acids is an important .finding,” they added.a joint Anglo-Iranian study reported that depression ratings were cut by 50 per cent following daily one gram supplements of EPA, an effect similar to that obtained by the antidepressant drug fluoxetine, according to findings published in the Australian and New Zealand Journal of Psychiatry.

Scientific research reveals brain alterations linking omega 3 fish oil deficit with depression

Thursday, May 26th, 2011

The link between deficits of omega-3 poly-unsaturated fatty acids (AGPO-3) and the onset of depressive disorders is not new in the medical field. However, what has not been known until now is the brain mechanism by which diet can condition mental health to a certain extent. Research undertaken by scientists in Bordeaux (France) and at the Faculty of Medicine and Odontology of the University of the Basque Country (UPV/EHU) and published in Nature Neuroscience, provides new clues to understanding this phenomenon.

The name of the research work, ‘Omega-3 nutritional deficiencies annul the neuronal functions of the endocannabinoid system’ describes the research findings, endocannabinoid system being linked to the onset of depressive disorders.

According to Doctor Susana Mato, researcher in the Ramón y Cajal programme, attached to the Neurosciences Department of the Faculty of Medicine and Odontology at the UPV/EHU and member of the Neurobiology Group, “we have observed that, in mice subjected to a diet low in omega-3 poly-unsaturated fatty acids, they have lower AGPO-3 brain levels, and this fact is associated with an alteration in the functioning of the endocannabinoid system”. More concretely, the researcher points to the confirmation of “the existence of a deficit in the signalling of the CB1 cannabinoid receptor in the prefrontal cortex of the brain. This protein — the CB1 cannabinoid receptor — has been linked, over the last decade and in various studies, to depressive disorders.”

Doctor Rafael Rodríguez-Puertas, research worker responsible for the Neurochemical and Neurodegeneration team at the Faculty of Medicine and Odontology at the UPV/EHU, points out that “certain forms of synaptic plasticity — a change in the efficiency of neuronal communication — measured by the brain’s endocannabinoid system, disappear specifically from certain zones of the brains of mice with AGPO-3 deficit”.

Despite several example in the scientific literature referring to the existence of a link between the low presence of AGPO-3 in the diet and depressive disorders, Susana Mato recognises that “little more is known about how modern Western diets, poor in AGPO-3, affect brain function and what might be the reason for a greater rate of depression associated with a deficit of these fatty acids”.

As doctor Rodríguez-Puertas points out, “thanks to the results of this research new possibilities are opened up for undertaking deeper research, such as how diet modifies the functioning of the brain in general and the endocannabinoid system in particular, and how this is linked to mental disorders”.

It also, “reinforces the idea that manipulating the endocannabinoid system can be useful for the treatment of depressive disorders, although the data we have up to now is very green for us to say what would be the ideal way to do so”, pointed out Dr Mato.

Collaboration amongst European researchers

The research work started with two French teams located in Bordeaux and led respectively by doctors Olivier J Manzoni and Sophie Layé. They have been working for a number of years with mice which show low levels of AGPO-3 in their brain, due to a low diet in these fatty acids.

“Dr Manzoni’s team discovered that the synaptic plasticity of the neuronal connections, which is mediated by endocannabinoids, disappears in these animals”, pointed out Dr S. Mato. To this end, in 2008, they made contact with researchers at the Faculty of Medicine at the UPV/EHU in order to obtain their collaboration in undertaking new research in order to identify possible change sin the expression and activity of the cannabinoid receptors.

In fact, in order to draw conclusions from the study, it has been necessary to employ a large number of research techniques, amongst which were “the analysis of the brain’s fatty acids, electrophysiology, autoradiography of receptors, the western blot (for quantification of proteins), the determination of levels of endocannabinoids and behaviour tests”, listed Doctor Rodríguez-Puertas. “In fact”, continued the researcher, “in our research team we are experts in the autoradiography of receptors technique and in anatomically identifying the activation of the receptors of the endocannabinoid system”.

Omega 3 Fish Oil and Depression , Mental Health as used in NHS

Monday, March 21st, 2011

Recent studies have shown that 1000mg EPA  omega 3 fish oil is as effective as Prozac in the treatment of medium to severe depression . When used together with the anti depressant it was even more effective than either treatment separately .
Forth Valley HealthBoard  recommend the brand takeomega 3  fish oil both as an adjunctive and primary therapy in medium to severe depression as well as other mental health disorders such as PTSD, OCD .
The reason they use and recommend Takeomega 3 fish oil  is primarily due to the fact this is the highest concentration currently available at just under 90% it also offers 750mg EPA per capsule with minimal quantities of DHA . The product is also manufactured in MHRA licensed facilities .

Forth Valley HealthBoard  Omega 3 Fish Oil Depression

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