Posts Tagged ‘bbc omega3’

Omega 3 Fish Oil benefits Intensifies the positive effect of Tamoxifen

Monday, April 11th, 2011

Female mice that ingested fish oil supplements with breast cancer drug tamoxifen appeared to have slowed the proliferation of their tumors, compared to rodents given corn oil with the drug, according to researchers at Fox Chase Cancer Center.

In the controlled study, the team of scientists found that the omega-3 fatty acids found in fish oil helped to slow gene expression related to tumor growth.

“If a tumor was being treated with tamoxifen, the addition of an omega-3 fatty acid diet seemed to make the tumor, at least at the molecular level, more benign and less aggressive and responsive to tamoxifen,” said lead researcher Jose Russo, M.D. TakeOmega3 due to its unique high EPA formulation with 750mg EPA per capsule and its high purity of 85% omega3 would be the ideal omega3 supplement to take alongside Tamoxifen . TakeOmega3 offers the highest concentration currently available and it is uniquely manufactured in facilities licensed by MHRA (Medical Health & Regulatory Authority) here in UK . No other omega3 supplement currently offers these benefits .

Additionally, the healthy fats appeared to curb immune responses that result in allergies and inflammation. These negative effects have been known to alter the body’s natural defense against cancer.

Next, the researchers hope to investigate how omega-3 fatty acids in a diet can affect risk of breast cancer in women.

Authors of the study noted that an estimated 200,000 women are diagnosed with the disease each year.

Breast cancer is the second most common cancer among women, with more than 200,000 women diagnosed each year. Being exposed to estrogen over a long period of time is one factor that can increase a woman’s risk of developing the disease. One way a woman can combat this risk factor is by taking the breast cancer drug tamoxifen, which interferes with the activity of estrogen. Now, researchers at Fox Chase Cancer Center have found that omega-3 fatty acids — abundant in fish — could be a safe and beneficial booster for tamoxifen therapy.

Jose Russo, MD, director of the Breast Cancer Research Laboratory at Fox Chase, is presenting the new findings at the AACR 102nd Annual Meeting 2011 on April 6.
To investigate how fish oil intensifies the effects of tamoxifen, Russo, in collaboration with a team led by Andrea Manni, MD, from Pennsylvania State University, induced mammary tumors in rats and then divided the animals into four groups. They fed the groups either a 17 percent fish oil diet, with or without tamoxifen, or a 20 percent corn oil diet, with or without tamoxifen, for eight weeks. They then analyzed gene expression patterns in the tumors. Omega-3 fatty acids produced a greater expression of genes related to cellular specialization, or differentiation — a sign of lower cancer severity — compared to corn oil. The combination of fish oil and tamoxifen reduced the expression of genes linked to tumor growth and spreading.

“The fish oil diet also boosted the expression of genes related to immune defenses against tumors, more so than did the corn oil diet. But omega-3 fatty acids simultaneously increased the expression of genes that trigger counterproductive immune responses, such as inflammation and allergic reactions, which curtail the ability of cells to fight cancer and can even promote the migration of tumor cells.

More studies are needed to fully understand the effects of fish oil on the immune system, Russo says. Meanwhile, his team is examining whether omega-3 fatty acids can prevent breast cancer in animals and testing the influence of diet on breast cancer risk in women.

Co-authors on the study include Bidinotto, L.T.; Vanegas, J.E.; Vanden Heuvel, J.P.; Lopez, R.; Santucci-Pereira, J.; Washington, S., Xu; H., Russo I.H.; El-Bayoumy, K.; and Manni, A. from Fox Chase.

Omega 3 EPA reduces LDL cholesterol levels – TakeOmega3 has 750mg EPA per capsule

Wednesday, December 15th, 2010

New clinical study results presented at the American Heart Association Scientific Sessions show that the long-chain omega-3 fatty acid EPA (eicosapentaenoic acid), helped significantly reduce small dense LDL (bad) cholesterol levels.

“This study suggests that supplementation with the omega-3 fatty acid EPA may present unique benefits for cardiovascular health,” said Sujata K. Bhatia, M.D., Ph.D., research associate with DuPont. “EPA was shown to have advantageous effects on several biomarkers, including LDL cholesterol, small dense LDL, and lp-PLA2.”

EPA is a long-chain fatty acid that is found primarily in cold water, fatty fish like sardines anchovies mackerel  as well as some omega-3 fatty acid such as TakeOmega3 which has 750 mg EPA per capsule  and is the highest grade omega 3 available in UK . A growing body of evidence suggests that EPA is the long-chain omega-3 that supports heart health.

The study, conducted by Cardiovascular Research Associates and sponsored by DuPont, was conducted among 110 healthy individuals comparing the effects of EPA supplements to DHA (docosahexaenoic acid) supplements on cardiovascular health. The participants were placed into four study groups and examined over a six week period. During that time, each group was monitored while taking: EPA 600 mg per day; EPA 1,800 mg per day; DHA 600 mg per day; and an olive oil placebo.

The study found that in the 1,800mg EPA group, there were significant reductions of 7 percent for small dense low density lipoprotein (LDL) cholesterol, and 6 percent for lipoprotein-associated phospholipase A2 (lp-PLA2). lp-PLA2 is an enzyme involved in vascular inflammation.
In contrast, the 600mg DHA group showed a significant increase in total small dense LDL cholesterol in both the fasting and fed state of 14.2 percent and 16.3 percent respectively.

The study results will be featured during the American Heart Association Conference poster session in Chicago

Great Britain Flag
Made in the UK - Take Omega 3 Suspendisse lacinia ultricies justo, at ultricies nisi tempus ac. Cras sed vehicula metus. Phasellus...