Posts Tagged ‘anti inflammatory’

Omega 3 Fish Oil EPA and DHA reduce anxiety and inflammation in healthy students

Thursday, July 14th, 2011

Omega-3 Reduces Anxiety and Inflammation in Healthy Students,
A new study gauging the impact of consuming more fish oil showed a marked reduction both in inflammation and, surprisingly, in anxiety among a cohort of healthy young people.

The findings suggest that if young participants can get such improvements from specific dietary supplements, then the elderly and people at high risk for certain diseases might benefit even more.
The findings by a team of researchers at Ohio State University were just published in the journal Brain, Behavior and Immunity. It is the latest from more than three decades of research into links between psychological stress and immunity.
Omega-3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have long been considered as positive additives to the diet. Earlier research suggested that the compounds might play a role in reducing the level of cytokines in the body, compounds that promote inflammation, and perhaps even reduce depression.
Psychological stress has repeatedly been shown to increase cytokine production so the researchers wondered if increasing omega-3 might mitigate that process, reducing inflammation.
To test their theory, they turned to a familiar group of research subjects — medical students. Some of the earliest work these scientists did showed that stress from important medical school tests lowered students’ immune status.
“We hypothesized that giving some students omega-3 supplements would decrease their production of proinflammatory cytokines, compared to other students who only received a placebo,” explained Janice Kiecolt-Glaser, professor of psychology and psychiatry.
“We thought the omega-3 would reduce the stress-induced increase in cytokines that normally arose from nervousness over the tests.”
The team assembled a field of 68 first- and second-year medical students who volunteered for the clinical trial. The students were randomly divided into six groups, all of which were interviewed six times during the study. At each visit, blood samples were drawn from the students who also completed a battery of psychological surveys intended to gauge their levels of stress, anxiety or depression. The students also completed questionnaires about their diets during the previous weeks.
Half the students received omega-3 supplements while the other half were given placebo pills.
“The supplement was probably about four or five times the amount of fish oil you’d get from a daily serving of salmon, for example,” explained Martha Belury, professor of human nutrition and co-author in the study.
Part of the study, however, didn’t go according to plans.
Changes in the medical curriculum and the distribution of major tests throughout the year, rather than during a tense three-day period as was done in the past, removed much of the stress that medical students had shown in past studies.
“These students were not anxious. They weren’t really stressed. They were actually sleeping well throughout this period, so we didn’t get the stress effect we had expected,” Kiecolt-Glaser said.
But the psychological surveys clearly showed an important change in anxiety among the students: Those receiving the omega-3 showed a 20 percent reduction in anxiety compared to the placebo group.
An analysis of the of the blood samples from the medical students showed similar important results.
“We took measurements of the cytokines in the blood serum, as well as measured the productivity of cells that produced two important cytokines, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFa),” said Ron Glaser, professor of molecular virology, immunology & medical genetics and director of the Institute for Behavioral Medicine Research.
“We saw a 14 percent reduction in the amounts of IL-6 among the students receiving the omega-3.” Since the cytokines foster inflammation, “anything we can do to reduce cytokines is a big plus in dealing with the overall health of people at risk for many diseases,” he said.
While inflammation is a natural immune response that helps the body heal, it also can play a harmful role in a host of diseases ranging from arthritis to heart disease to cancer.

Rheumatoid Arthritis benefits of omega 3 fish oil

Tuesday, May 3rd, 2011

There has been great interest in the use of omega3 fish oil EPA and DHA which is a key anti inflammatory . There have been numerous studies sine the early 1980’s looking at the benefits in taking omega 3 fish oil both as a preventative measure as well as therapeutic treatment for the condition. There are at least 13 randomized clinical controlled studies that show clear benefits of taking fish oil – a common outcome in these studies has been a reduction in symptoms and tender joints. More importantly there was a reduction in analgesic anti inflammatory drugs used . For those people who have a family history of rheumatoid arthritis they should look to make dietary changes and decrease the amount of omega 6 they take which is pro inflammatory and increase the omega3 specifically EPA / DHA the key active ingredients

Omega3 a key anti inflammatory

Tuesday, March 22nd, 2011

Inflammation is a natural reaction by the body to allow itself to repair and is infact a key defense mechanism. It is a reaction to a number of factors such as injury , infection , allergens and chronic disease.
The body when it is under attack by one or more of these factors creates a cellular reaction – the cells effectively upregulate production of numerous molecules and as a result there is redness, swelling and pain in the tissue involved. When this happens immune cells go to the site of the inflammation where they help to destroy and get rid of the offending stimuli.
The acute inflammatory response is usually self limiting and an integral part of the healing process . However if this does get out of control the inflammation can damage tissues and hinder the body’s repair mechanisms and as a result chronic disease can be the result such as osteoarthritis , rheumatoid arthritis, . Chronic inflammation is implicated in a large number of systemic disorders including hearrt disease, type 2 diabetes, hypertension , diabetes mellitus, metabolic syndrome, neurodegeneration . It is therefore essential for good health to maintain a properly modulated metabolic pathway as it is the metabolic pathways that lead to overproduction of inflammatory mediators.
Conventional treatment of pro inflammatory conditions and diseases typically involves the use of non steroidal anti inflammatory drugs – however these are not always effective and can have serious implications on gastrointestinal , renal , cardio health with regards the side effects. As a result of this research is ongoing looking at more natural ways to treat inflammation – one of the most consistent performers in this is omega3 specifically EPA which has been shown to have perhaps the most powerful ability to modulate key inflammatory mediators such as COX-2.

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