Omega-3s intake Linked to Lower Amyloid Levels and reduced risk of Alzheimers

A study of diet and plasma beta-amyloid in cognitively normal individuals over 65 found that increased consumption of omega-3 fatty acids was significantly associated with lower plasma levels of beta-amyloid protein 42.
Note that none of the other nutrients were found to have a significant association with plasma beta-amyloid.

People who had a lot of omega-3 fatty acids in their diets tended to have lower plasma levels of beta-amyloid proteins, possibly reducing their risk of Alzheimer’s disease, researchers said.

In a cross-sectional study of more than 1,200 cognitively normal individuals older than 65, omega-3 fatty acid intake was significantly predictive of plasma levels of the 40- and 42-residue forms of beta-amyloid protein (AB40 and AB42, respectively), according to Nikolaos Scarmeas, MD, of Columbia University in New York City, and colleagues.

Adjusting for age, education level, and other factors pushed the relationship between AB40 and omega-3 intake into a strong but nonsignificant trend (beta statistic -10.13, P=0.13). But the association with AB42 remained significant, Scarmeas and colleagues reported online in Neurology (beta statistic -7.70, P=0.02).

The same group had previously published results indicating that a Mediterranean-type diet was associated with lower risk of cognitive impairment and Alzheimer’s disease.

Because one of the hallmarks of Alzheimer’s disease is beta-amyloid plaque deposits in the brain, Scarmeas and colleagues sought to determine if dietary factors were related to blood levels of AB40 and AB42.

Their study population was drawn from participants in the Washington Heights/Hamilton Heights Columbia Aging Project in New York City, first recruited in 1992 with a second group enrolled in 1999.

As part of this study, participants completed a detailed diet questionnaire and also provided blood samples. The latter were drawn a mean of 1.2 years after collection of dietary information.

The researchers excluded participants already showing dementia when the dietary questionnaire was administered, since their mental status could affect their self-reporting on diet.

A total of 1,219 participants out of the original 2,778 were included in the current analysis. In addition to 345 with prevalent dementia, another 1,025 could not be included because beta-amyloid levels in plasma weren’t measured.

In addition to omega-3 intake, Scarmeas and colleagues also estimated intake of nine other nutrients: folate, beta-carotene, monounsaturated fats, saturated fats, omega-6 fatty acids, and vitamins C, D, E, and B12.

Only omega-3 intake was significantly associated with plasma AB40 or AB42 levels in any analysis.

The raw data suggested a powerful link:

AB40: beta -24.74, P<0.001

AB42: beta -12.31, P<0.001

But analysis of participant characteristics revealed a number of covariates. Adjusting for age, race-ethnicity, education level, APOE genotype, total caloric intake, and recruitment wave attenuated the relationships noticeably. The beta value for AB40 shrank to -11.96 and the P value increased to 0.06.

The beta value for AB42 also declined, to -7.31, but it remained significant at P=0.02.

Adding adjustments for alcohol drinking and use of certain drugs and nutritional supplements changed the strength of the associations only slightly.

The researchers' conclusion: "The potential beneficial effects of omega-3 [fatty acid] intake on Alzheimer's disease and cognitive function in the literature might be at least partly explained by an AB-related mechanism," they wrote.

Scarmeas and colleagues noted several limitations to the study, including its cross-sectional design and its reliance on a single measurement of plasma AB40 and AB42 levels, which they characterized as "a moving target" during development of cognitive decline.

Also, the researchers relied on participants' self-reports on diet and examined only 10 of many nutrients contained in food.

Finally, Scarmeas and colleagues acknowledged that plasma beta-amyloid proteins do not necessarily reflect amyloid protein levels in the brain.

Related posts:

  1. Omega-3 Fish Oil EPA and DHA Intake Linked With Reduced Risk of Age-Related Macular Degeneration in Women
  2. ADHD reduced by 60% by increasing intake of omega3 during pregnancy .
  3. Diet high in Omega3 and low in cholesterol could reduce risk of developing Alzheimers
  4. Omega3 Fish oil supplementation during pregnancy is associated with reduced risk of infant allergy / sensitization & better immune system
  5. Omega-3 fish oil is Linked To Decreased Inflammation And Decreased Fatigue in Breast Cancer

Tags: , , , , ,

Leave a Reply

Great Britain Flag
Made in the UK - Take Omega 3 Suspendisse lacinia ultricies justo, at ultricies nisi tempus ac. Cras sed vehicula metus. Phasellus...