Omega-3 fish oil As Possible Therapeutic Agent In Breast & Prostate Cancers

Omega-3FA As Possible Therapeutic Agents In Breast & Prostate Cancers

Brown I, Wahle KW, Cascio MG, et al. Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids (fish oil ) in different human prostate and breast cancer cell lines. Prostaglandins Leukot Essent Fatty Acids. 2011 Oct 11.

Omega-3  fatty acids (fish oil ) inhibit breast and prostate cancer cell growth.

We previously showed that N-acylethanolamine derivatives of n-3 (n-3-NAE) are endocannabinoids, which regulate cancer cell proliferation. These n-3-NAE are synthesised in certain cells/tissues, after supplementing with omega 3 essential fatty acids found in fish oil , however, no one has assessed whether and to what extent this occurs in cancer cells.

We determined levels of endogenous n-3-NAEs in hormone sensitive and insensitive prostate and breast cancer cells and subsequent effects on other endocannabinoids (anandamide and 2-arachidonoylglycerol), before and after supplementing with DHA and EPA fatty acids which are the active ingredient of fish oil , using HPLC tandem mass spectrometry.

This is the first study reporting that omega 3 -NAEs are synthesised from their parent omega 3  fatty acids in cancer cells, regardless of tumour type, hormone status or the presence of fatty acid amide hydrolase.

This could have important implications for the use of omega 3  fatty acids ( fish oil ) as therapeutic agents in breast and prostate cancers expressing cannabinoid receptors.

Related posts:

  1. Omega 3 fish oil supplementation slows growth of prostate cancer cells
  2. Prostate Cancer – Omega3 fish oil benefits offers protection against advanced prostate cancer
  3. Omega 3 and Prostate Cancer
  4. High strength Omega3 appears to inhibit breast cancer cell growth
  5. Omega-3 PUFA Inhibit Human Breast Cancer Cell Growth

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