Initiating therapy with second-generation antipsychotics (SGAs) in children and adolescents has been linked to an increased risk of developing diabetes within 1 year

Initiating therapy with second-generation antipsychotics (SGAs) in children and adolescents has been linked to an increased risk of developing diabetes within 1 year, new research suggests.

A large retrospective study shows previously SGA-naive children and youth may have up to a 4-fold increased rate of incident diabetes mellitus (DM) compared with children not using any psychotropic medications.

“We found an increased incidence of diabetes among children within the first year after initiation of SGA therapy, compared with children who were not using any psychotropic medications. This finding persisted when the incidences of both diabetes and abnormal glucose laboratory values were evaluated,” the researchers write.

However, the study showed no difference in DM rates in children and adolescents taking SGAs and their counterparts initiating therapy with antidepressant medications.

With lead author Susan E. Andrade, ScD, the study was published online November 21 in Pediatrics.


The side effects of the new second-generation antipsychotic medicines vary these medicines are prescribed for conditions such as schizophrenia

Side effects that all these medicines may have include:

  • Feeling sleepy or tired.
  • Gaining weight.
  • Developing high cholesterol
  • Developing high blood sugar

The makers of Risperdal, seroqual , and zyprexa have warned that high blood sugar or type 2 diabetes may be more likely in people who are taking these medicines.

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