High Dose EPA / DHA up to 5g / day DO NOT increase risk of bleeding -European Food Safety Authority

European Food Safety Authority state
Long-term supplemental intakes of EPA and DHA combined up to about 5 g/day do not increase the risk of spontaneous bleeding episodes or bleeding complications even in subjects at high risk of bleeding (e.g. taking acetylsalicylic acid or anti-coagulants).or affect glucose homeostasis immune function or lipid peroxidation,

DHA at doses of 2 4 g/day, induce an increase in LDL-cholesterol concentrations of about 3 % which may not have an adverse effect on cardiovascular disease risk, whereas EPA at doses up to 4 g/day has no significant effect on LDL cholesterol.

Supplemental intakes of EPA and DHA combined at doses up to 5 g/day, and supplemental intakes of EPA alone up to 1.8 g/day, do not raise safety concerns for adults.

he Panel concludes that the available data are not sufficient to establish a tolerable upper intake level for n-3 LCPUFA (DHA, EPA, and DPA, individually or combined) for any population group.

At observed intake levels, consumption of n-3 LCPUFA has not been associated with adverse effects in healthy children or adults.

The Panel considers that supplemental intakes of EPA and DHA combined at doses up to 5 g/day, and supplemental intakes of EPA alone up to 1.8 g/day, do not raise safety concerns for the adult population. Limited data are available on the effects of long-term supplementation with these n-3 LCPUFAs at higher doses. The Panel also notes that observed intakes of EPA and DHA from food and food supplements in European populations are generally below these amounts.

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