Archive for July, 2012

Omega3 Fatty acid EPA most potent omega3 for inflammation and healing in athletes Omega3 EPA accelerates ligament healing

Tuesday, July 24th, 2012

Omega3 Fatty acid EPA most potent omega3 for inflammation and healing in athletes – TakeOmega3 HFL tested
Omega3 EPA accelerates ligament healing

Ligaments are tough bands of fibrous connective tissue (mainly collagen) that link two bones together at a joint. Injuries to ligaments are notoriously slow to heal. Researchers at Purdue University now report the results of an intriguing experiment which shows that eicosapentaenoic acid (EPA – one of the acitive ingredients iin fish oil materially speeds up the healing of “wounded” ligament cells in vitro. The experiment was carried out on three cultures of animal medial collateral ligament cells. The first culture was treated with arachidonic acid (an n-6 polyunsaturated fatty acid), the second with eicosapentaenoic acid (an n-3 polyunsaturated fatty acid), and the third served as a control.
After four days the cells were analyzed to determine their fatty acid profile. The AA (arachidonic acid) treated cells were found to have an n-6 to n-3 ratio of 24.3 while the EPA (eicosapentaenoic acid) treated cells had a ratio of 1.1. This indicates that the two fatty acids were well-absorbed and incorporated into the cells. Next a “wound” was introduced into the surface layers of the cell cultures by streaking a sterile pipette across them. The rate at which ligament cells grew back into the “wound” was measured over a 72-hour period and taken as an indication of wound healing speed. Both the AA and EPA treated cultures showed a higher degree of regrowth in the wound area than did the control. However, while AA decreased the synthesis of collagen by the ligament cells, EPA markedly increased it.
The researchers conclude that dietary supplementation with omega3 fish oils specifically EPA (n-3 polyunsaturated fatty acid) could be used to improve the healing of ligament injuries by enhancing the entry of new cells into the wound area and by speeding up collagen synthesis.
Source
Hankenson, Kurt D., et al. Omega-3 fatty acids enhance ligament fibroblast collagen formation in association with changes in interleukin-6 production. Proceedings of the Society for Experimental Biology and Medicine

Omega 3 and chronic tendon disorders in athletes
Does Omega 3 have any benefit in the treatment of chronic tendon disorders ? This is a major problem amongst recreational athletes and we do get asked if taking a high dose omega 3 such as Take Omega3 which is high in the key anti – inflammatory essential fatty acid EPA and is also HFL tested would be of any help . Several years ago there was a study conducted whereby they evaluated treatment with essential fatty acids and antioxidants combined with physiotherapy.
Methods and measures
In a randomised, double-blind, placebo-controlled trial 40 volunteers active in recreational sports with chronic tendon disorders were assigned to the study. The subjects were divided in two groups, one consuming a daily dosage of essential fatty acids and antioxidants and one consuming similar placebo. Furthermore, the subjects received 16 sessions of ultrasound treatment over 32 days. Evaluation was pain scores, rated on a visual analogue scale and quantification of normal sports activity during treatment.
Results
In the treatment group there was a significant reduction of pain compared with the placebo group (P<0.001) after 32 days. There was a mean decrease in pain score of 99% in the treatment group compared with a mean decrease of 31% in the placebo group. Sport-specific activity increased by 53% in the treatment group and increased by 11% in the placebo group.
Conclusions
The results suggest beneficial effect of essential fatty acids and antioxidants in combination with physiotherapy treating chronic tendon disorders.

Omega 3 essential fatty acid EPA Reduces Inflammation
Athletes often undergo high-intensity training that increases inflammation and the risk for pain and injury. This can decrease exercise performance and the ability to recover properly. Omega-3 fatty acids fish oil specifically EPA is effective in reducing inflammation. Researcher Dr. William Smith from the University of Massachusetts found that omega-3 fatty acids decrease inflammation by diminishing the production of prostaglandin's, hormone-like substances associated with inflammation in the body. Omega 3 EPA is the most powerful natural anti inflammatory and unlike pharmaceutical anti inflammatory products there are no health risks or side effects when taking them .
Improves Body Composition

Athletes often focus on body composition, or fat to muscle ratio, in order to stay in top physical shape and maximise training and performance. In a study published in the October issue of the “Journal of the International Society of Sports Nutrition,” found that participants taking fish oil for six weeks improved their body composition by increasing lean muscle mass and decreasing fat mass. Omega 3 specifically EPA offers better oxygen delivery during exercise and also is key in removing lactic acid from the body
Quicker Recovery after exercise
Omega 3 specifically EPA can significantly reduce the time required for fatigued muscles to recover after exercise. They do this by helping the conversion of lactic acid to water and carbon dioxide. Omega 3 ’s are part of all cell membranes where they act as structural components and also maintain the fluidity of the cell. They are involved with the movement of substances into the cell (e.g. nutrients) and out of the cell (e.g. waste products) and also with cell to cell communication by helping to generate electrical impulses.
takeomega3 has one of the highest concentrations of EPA among the multitude of Omega 3 fish oils on the market. Indeed it is of pharmaceutical grade. Each capsule can contain as much as 10x the EPA found in other products. TakeOmega3 is also HFL tested .
takeomega3 is already being suggested as an alternative to Prozac by medical professionals– a health supplement as opposed to a pharmaceutical drug.
Eating oily fish or an equivalent can help improve the take-up of omega 3, but can never bring EPA concentrations to medically beneficial levels.
About the product
takeomega3 is an 85% pharmaceutical grade omega 3 fish oil and offers the highest concentration currently available.
takeomega3 is manufactured in one of just two MHRA (Medical Health and Regulatory Authority) licensed facilities for the sale and manufacture of omega 3 fish oil in the UK.
takeomega3 is recommended by NHS doctors and nurses and also doctors at private hospitals and clinics such as The Priory.
Each of the takeomega3 fish oil capsules contains at least 750mg EPA and 50mg DHA
takeomega3 only uses sardines and anchovies from sustainable fish stocks
As a comparison, it is worth comparing how much active ingredient is included in any rival product - it can be as low as 15%. (1000mg Omega 3 does not refer to active ingredients – it is the level of EPA and DHA that counts.)

Omega3 Fish oil supplementation during pregnancy is associated with reduced risk of infant allergy / sensitization & better immune system

Monday, July 23rd, 2012

Omega 3 Fish oil supplementation in early infancy modulates developing infant immune responses.
D’Vaz N, Meldrum SJ, Dunstan JA, Lee-Pullen TF, Metcalfe J, Holt BJ, Serralha M, Tulic MK, Mori TA, Prescott SL.
Source

School of Paediatrics and Child Health, University of Western Australia (UWA), Perth, WA, Australia.
Abstract
BACKGROUND:

Maternal fish oil supplementation during pregnancy has been associated with altered infant immune responses and a reduced risk of infant sensitization and eczema.
OBJECTIVE:

To examine the effect of early postnatal fish oil supplementation on infant cellular immune function at 6 months of age in the context of allergic disease.
METHODS:

In a double-blind randomized controlled trial (ACTRN12606000281594), 420 infants of high atopic risk received fish oil [containing 280 mg docosahexaenoic acid (DHA) and 110 mg eicosapentanoic acid (EPA)] or control oil daily from birth to 6 months. One hundred and twenty infants had blood collected at 6 months of age. Fatty acid levels, induced cytokine responses, T cell subsets and monocyte HLA-DR expression were assessed at 6 months of age. Infant allergies were assessed at 6 and 12 months of age.
RESULTS:

DHA and EPA levels were significantly higher in the fish oil group and erythrocyte arachidonic acid (AA) levels were lower (all P < 0.05). Infants in the fish oil group had significantly lower IL-13 responses (P = 0.036) to house dust mite (HDM) and higher IFNγ (P = 0.035) and TNF (P = 0.017) responses to phytohaemaglutinin (PHA). Infants with relatively high DHA levels had lower Th2 responses to allergens including lower IL-13 to β-lactoglobulin (BLG) (P = 0.020), and lower IL-5 to BLG (P = 0.045).
CONCLUSIONS AND CLINICAL RELEVANCE:

Postnatal fish oil supplementation increased infant n-3 polyunsaturated fatty acid (PUFA) levels and associated with lowered allergen-specific Th2 responses and elevated polyclonal Th1 responses. Our results add to existing evidence of n-3 PUFA having immunomodulatory properties that are potentially allergy-protective.

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