Archive for February, 2012

Omega 3 and benefits to Cancer / Cardio Health

Saturday, February 18th, 2012

A recent study reported that higher intakes of the long-chain omega-3s fish oil EPA /DHA are associated with a lower risk of adenomatous polyps in women (Murff et al., 2012).

The long-chain omega-3s have been shown to reduce the effects of cancer-related cachexia (Colomer et al., 2007).

There are a multitude of studies demonstrating increased effectiveness of anticancer agents by long-chain omega-3s. One such study is Bougnoux et al., 2009.

With respect to the results from the primary analysis reported back in 2010, the most likely reason the long-chain omega-3s did not prevent major cardiovascular events in patients with pre-existing cardiovascular disease is that the dose was too low (600 mg EPA + DHA). Consider that the American Heart Association recommends 1 g/day of EPA+DHA for individuals with coronary heart disease.

Omega 3 Fish Oil EPA , DHA Marine-derived n−3 (omega-3) PUFAs may reduce risk of developing colorectal / bowel cancer 3 Cancer

Saturday, February 18th, 2012

Background: Marine-derived n−3 (omega-3) PUFAs may reduce risk of developing colorectal cancer; however, few studies have investigated the association of n−3 PUFA intakes on colorectal polyp risk.

Objective: The objective of this study was to examine the associations of dietary PUFA intake on risk of colorectal adenomatous and hyperplastic polyps.

Design: This was a colonoscopy-based case-control study that included 3166 polyp-free control subjects, 1597 adenomatous polyp cases, and 544 hyperplastic polyp cases. Dietary PUFA intake was calculated from food-frequency questionnaires and tested for association by using unconditional logistic regression. The urinary prostaglandin E2 metabolite, which is a biomarker of prostaglandin E2 production, was measured in 896 participants by using liquid chromatography and tandem mass spectrometry.

Results: n−6 PUFAs were not associated with adenomatous or hyperplastic polyps in either men or women. Marine-derived n−3 PUFAs were associated with reduced risk of colorectal adenomas in women only, with an adjusted OR of 0.67 (95% CI: 0.47, 0.97) for the highest quintile of intake compared with the lowest quintile of intake (P-trend = 0.01). Dietary intake of α-linolenic acid was associated with an increased risk of hyperplastic polyps in men (P-trend = 0.03), which was not seen in women. In women, but not in men, dietary intake of marine-derived n−3 PUFAs was negatively correlated with urinary prostaglandin E2 production (r = −0.18; P = 0.002).

Conclusion: Higher intakes of marine-derived n−3 PUFAs / omega3 from fish oil are associated with lower risk of adenomatous polyps in women, and the association may be mediated in part through a reduction in the production of prostaglandin E2. This trial was registered at clinicaltrials.gov as NCT00625066.

Dietary intake of PUFAs and colorectal polyp risk1,2,3,4
Harvey J Murff, Martha J Shrubsole, Qiuyin Cai, Walter E Smalley, Qi Dai, Ginger L Milne, Reid M Ness, and Wei Zheng

Omega 3 Fish Oil Increases Chemotherapy success and may contribute to increased survival rate

Friday, February 10th, 2012

Omega 3 Fish Oil Increases Chemotherapy success and may contribute to increased survival rate
Murphy RA, Mourtzakis M, Chu QS, et al. Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. Cancer. 2011 Aug 15;117(16):3774-80.
BACKGROUND: Palliative chemotherapy is aimed at increasing survival and palliating symptoms. However, the response rate to first-line chemotherapy in patients with nonsmall cell lung cancer (NSCLC) is less than 30%. Experimental studies have shown that supplementation with omega3 fish oil can increase chemotherapy efficacy without negatively affecting nontarget tissue. This study evaluated whether the combination of omega3 fish oil and chemotherapy (carboplatin with vinorelbine or gemcitabine) provided a benefit over standard of care (SOC) on response rate and clinical benefit from chemotherapy in patients with advanced NSCLC.

METHODS: Forty-six patients completed the study, n = 31 in the SOC group and n = 15 in the FO group (2.5 g EPA / DHA per day day). Response to chemotherapy was determined by clinical examination and imaging. Response rate was defined as the sum of complete response plus partial response, and clinical benefit was defined as the sum of complete response, partial response, and stable disease divided by the number of patients. Toxicities were graded by a nurse before each chemotherapy cycle. Survival was calculated 1 year after study enrollment.

RESULTS: Patients in the Omega 3 Fish Oil group had an increased response rate and greater clinical benefit compared with the SOC group (60.0% vs 25.8%, P = .008; 80.0% vs 41.9%, P = .02, respectively). The incidence of dose-limiting toxicity did not differ between groups (P = .46). One-year survival tended to be greater in the FO group (60.0% vs 38.7%; P = .15).

CONCLUSIONS: Compared with SOC, supplementation with omega3 fish oil results in increased chemotherapy efficacy without affecting the toxicity profile and may contribute to increased survival.

Supplementation with omega-3 fatty acid specifically EPA may decrease symptoms of attention-deficit/hyperactivity disorder (ADHD) in children, meta-analysis suggests – Yale Child Study Centre – Yale School of Medicine

Monday, February 6th, 2012

Supplementation with omega-3 fatty acid specifically EPA may decrease symptoms of attention-deficit/hyperactivity disorder (ADHD) in children,
meta-analysis suggests – Yale Child Study Centre – Yale School of Medicine

In an evaluation of 10 trials with 699 total children with ADHD, investigators found that those who received omega-3 supplements had a “small but significant” improvement in symptom severity compared with those who were given placebo. This effect was also significant in the children who received supplements that specifically contained higher doses of eicosapentaenoic acid.

“I was actually expecting this treatment to not be effective at all, that we shouldn’t expect much from a nutritional supplement that often takes a while to work. So the results were a surprise to me,” lead author Michael H. Bloch, MD, assistant professor at the Yale Child Study Center at Yale University School of Medicine in New Haven, Connecticut,

Omega 3 Essential Fatty key to Fuel Partitioning in the body . Research shows increase in muscle performance related to intake of omega3 essential fatty acids

Monday, February 6th, 2012

Omega 3 Essential Fatty key to Fuel Partitioning in the body . Research shows increase in muscle performance related to intake of omega3 essential fatty acids
• Decreasing Inflammation
• Increasing lean Muscle Growth
• Speeding Recovery time and better oxygen delivery during exercise
• Supporting Health Joints and Connective Tissue
• Aiding in Nerve Impulse Transmission
• Enhancing Cardiovascular Health
• Improves focus / concentration
• Prevents lactic acid build up

Omega 3 Essential Fatty Acids from Fish oil specifically EPA exert significant control over key metabolic genes in our cells. Particularly those involved in fat storage, fat burning and glycogen synthesis. Glycogen is stored carbohydrate energy. Fats high in Omega-3 play an essential role in maintenance of energy balance and glucose metabolism.

Scientists and Researchers have documented a phenomenon known as ‘fuel partitioning’, whereby dietary Omega3 essential fatty acids specifically EPA were able to direct glucose (from digested carbohydrates) towards glycogen storage while at the same time directing other fatty acids in the body away from triglyceride synthesis (ie fat storage) and towards fatty acid oxidation In addition, these studies suggested that omega-3 fatty acids have the unique ability to enhance thermogenesis (the burning of excess fat to produce heat), thereby reducing the efficiency of body fat deposition. What this means is that this fuel partitioning phenomenon appears to conserve carbohydrate while simultaneously shedding fat .

Research scientists studied the effects of omega-3 fat supplementation on swimming performance in rats . By comparison with a control group of unsupplemented rats, there was a 300% rise in the ‘swimming muscle’ levels of FABP, a protein that binds fatty acids and transports them to the mitochondria for oxidation, but no increase in muscle triglycerides. In a study on rat muscle fibers, high omega-3 produced 16-21% more muscle tension and up to 32% greater endurance during high frequency stimulation. Moreover, when these rats resumed their standard diets for a period of six weeks, their muscle function returned to the level of un-supplemented rats.

Obviously you have to take high concentration omega3, EPA in particular is key to the above processes. Many of you will have seen supplements on sale advertising 1000mg Omega3 with terms such as highest concentrations – do not be fooled by this – these formulations are usually at most 30% concentrates and very often lower – it basically means you are taking 70% filler oil . As well as that multiple low concentration products do not equate to 1 highly concentrated capsule of Take Omega3 – Research has shown that multiple capsules of low concentrate products do not benefit or act in the same way as one highly concentrated product of 85% or above. Take Omega3 is the highest concentration product available and each capsule has 750mg EPA and 50mg DHA we dont use filler oils . The human diet has too much of the pro inflammatory omega 6 in their diet so why take more via a supplement.

TakeOmega3 the healthy solution for weightloss

Sunday, February 5th, 2012

TakeOmega3 the healthy solution for weightloss

By taking Omega 3 high concentration EPA essential fatty acid you reduce inflammation that promotes weight gain. Not only that you improve skin tone and clarity , improve mood and body composition.
• Omega 3 enables burning of dietary fats by transporting fatty acids into the mitochondria of our cells for burning as fuel.
• Omega 3 enhances “fuel efficiency” by exerting positive influences on the process of fuel partitioning.
• Improve blood sugar control by sensitizing our cells and enabling receptors to respond to even small amounts of insulin.
• Stimulate the secretion of leptin, a peptide hormone that is produced by fat cells. Leptin acts on the hypothalamus to suppress appetite and burn fat stored in adipose tissue (fat cells).
• Improve fatty acid balance by reducing conversion of dietary omega-6 EFAs to arachidonic acid.
• Influence key anti-obesity genetic switches (nuclear transcription factors) that govern both inflammation and conversion of food to body fat.
• Omega3 activates perixosome proliferator-activated receptors (PPARs), which increases the burning of body fat, increases thermogenesis, increases insulin sensitivity, and decreases levels of inflammation.
— Prevent activation of NfkB.
— Omega-3 (and omega-6) block the release of sterol response element binding protein-1 (SREBP-1), which switches on the gene that codes for fatty-acid synthase, an enzyme that helps create body fat.
• Omega-3 and omega-6 enhance the body’s ability to transport glucose from our blood to our cells via an “insulin responsive transporter” called GLUT4; they do this by optimising the fluidity of cell membranes.
We recommend a dose of three capsules per day taken with meals to promote weightloss – Even though omega 3 fish oil is basically a “food,” always check with your primary health-care professional before embarking on any new supplement. Any therapeutic intervention, even nutritional supplements, can be contraindicated in certain health conditions. This is especially true with heart patients. Numerous studies have shown that fish oil helps protect against sudden cardiac death and abnormal heart rhythms called arrhythmias however it is always best to check. It does take time for the levels of EPA and most people notice a difference within 4 weeks.
Please contact us for pricing for the month weightloss program as we do offer a special discount package The incredible anti-inflammatory power of omega-3 essential fatty acids found in the high-fat fish and in high concentration omega 3 fish oil high in EPA can accomplish the following:
reduce inflammation in all organ systems
accelerate the loss of body fat
elevate mood
improve attention span / concentration / focus
stabalise blood sugar levels – lower insulin levels
create and maintain healthy serotonin levels
stop the roller-coaster effects of the carbohydrate highs and lows
decrease appetite
increase radiance to skin
increase health of the immune system
increase energy levels
decrease symptoms and severity of rheumatoid arthritis
reduce symptoms and severity of chronic skin conditions such as eczema
decrease cardiovascular risk
improvement in sleep quality
help protect against chronic disease and is the only solution to prevent Cancer Malnutrition

takeomega3 has the highest concentrations of EPA among the multitude of Omega 3 fish oils on the market. Indeed it is of pharmaceutical grade. Each capsule contains 750mgEPA which is as much as 10x the EPA found in other products
takeomega3 is already being suggested as an alternative to Prozac by medical professionals– a health supplement as opposed to a pharmaceutical drug.
Eating oily fish or an equivalent can help improve the take-up of omega 3, but can never bring EPA concentrations to medically beneficial levels.

Omega 3 fish oil supplementation enhances strength training in elderly women

Wednesday, February 1st, 2012

Omega 3 fish Oil Enhances Effects of Strength Training in Elderly Women

Rodacki CL, Rodacki AL, Pereira G, et al. Omega 3 Fish-oil supplementation enhances the effects of strength training in elderly women. Am J Clin Nutr. 2012 Feb;95(2):428-36.

BACKGROUND:
Muscle force and functional capacity generally decrease with aging in the older population, although this effect can be reversed, attenuated, or both through strength training. Fish oil (FO), which is rich in n-3 (omega-3) PUFAs, has been shown to play a role in the plasma membrane and cell function of muscles, which may enhance the benefits of training. The effect of strength training and Omega 3 Fish oil on the neuromuscular system of the elderly has not been investigated.

OBJECTIVE:
The objective was to investigate the chronic effect of Omega 3 Fish Oil supplementation and strength training on the neuromuscular system (muscle strength and functional capacity) of older women.

DESIGN:
Forty-five women (aged 64 ± 1.4 y) were randomly assigned to 3 groups. One group performed strength training only (ST group) for 90 d, whereas the others performed the same strength-training program and received FO supplementation (2 g/d) for 90 d (ST90 group) or for 150 d (ST150 group; supplemented 60 d before training). Muscle strength and functional capacity were assessed before and after the training period. Results: No differences in the pretraining period were found between groups for any of the variables. The peak torque and rate of torque development for all muscles (knee flexor and extensor, plantar and dorsiflexor) increased from pre- to posttraining in all groups. However, the effect was greater in the ST90 and ST150 groups than in the ST group. The activation level and electromechanical delay of the muscles changed from pre- to posttraining only for the ST90 and ST150 groups. Chair-rising performance in the Omega 3 fish oil groups was higher than in the ST group.

CONCLUSIONS:
Strength training increased muscle strength in elderly women. The inclusion of Omega 3 fish oil supplementation caused greater improvements in muscle strength and functional capacity.

Women who eat about three servings of oily fish per week have a somewhat lower chance of having colon polyps which can develop into cancer

Wednesday, February 1st, 2012

Women who eat about three servings of oily fish per week have a somewhat lower chance of having colon polyps, which can develop into cancer, than women who eat less than a serving a week, according to a U.S. study. Omega 3 EPA

Though the research, which covered more than 5,000 people and appeared in The American Journal of Clinical Nutrition, didn’t prove that seafood protects against polyps, earlier experiments in animals have showed that the omega-3 fatty acids in fish can reduce the risk of colorectal cancer.

About 140,000 new cases of colon and rectal cancer are diagnosed each year in the United States, and the lifetime risk of developing it is about 20 percent, according to the American Cancer Society.

“(The research) does increase our confidence that something real is going on,” said Edward Giovannucci, a professor at the Harvard School of Public Health, who didn’t work on the study.

The idea that researchers have been pursuing is that the omega-3 fats found in oily fish might have an anti-inflammatory effect, similar to aspirin, that could prevent the growth of polyps.

For the latest study, researchers led by Harvey Murff, a professor at Vanderbilt University in Nashville, Tennessee, surveyed more than 5,300 people about their eating habits. All had come in for a routine colonoscopy.

The team then compared more than 1,400 women without polyps to 456 who had polyps, also called an adenoma, detected during the procedure.

Among women with polyps, 23 percent were in the bottom fifth among fish eaters, while 15 percent were in the top fifth. That means that people who eat lots of seafood are somehow protected, because otherwise the percentages should have been the about the same.

After accounting for differences such as age, smoking and aspirin use, women who ate the most fish, three servings a week, were 33 percent less likely to have a polyp detected than those who ate the least, or less than a serving a week.

But other factors explaining the findings can’t be ruled out. For instance, fish lovers may have other healthy behaviors that decrease their risk of polyps.

The study also didn’t follow the women to see whether either group was more likely to go on to develop cancer, but Murff said that polyps are a reliable predictor of cancer risk.

“You would think most things that would reduce adenoma risk would subsequently reduce cancer risk,” he told Reuters Health.

The men in Murff’s study who ate a lot of fish did not have the same reductions in polyp risk as women, however.

Murff said he didn’t have a good explanation for that, but that perhaps men are less sensitive to the omega-3s in fish and need to eat more to get the benefit.

It could also be that men eat more omega-6 fats, found in a broad range of foods including chicken and nuts, which counteract the impact of the omega-3s. Omega-6 fatty acids are related to the production of a hormone called prostaglandin E2, which is associated with inflammation.

Eating Omega-3 fatty acids which contain EPA / DHA keeps down the level of Omega-6 acids, which in turn cuts levels of the hormone, Murff said. He noted that the women in the study who ate more fish — and presumably, more Omega-3s — had lower levels of the hormone.

“We know people who have higher levels of this (hormone) are more likely to develop colorectal/ bowel cancer. So in essence, by eating more Omega-3 fatty acids, it’s almost like taking an anti-inflammatory medication,” he told Reuters Health

Omega-3 fish oil fatty acids EPA for indicated prevention of psychotic disorders in young adults

Wednesday, February 1st, 2012

Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial.

Amminger GP, Schäfer MR, Papageorgiou K, Klier CM, Cotton SM, Harrigan SM, Mackinnon A, McGorry PD, Berger GE.
Source

Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria. gpamminger@gmail.com

Abstract

CONTEXT:

The use of antipsychotic medication for the prevention of psychotic disorders is controversial. Long-chain omega-3 (omega-3) polyunsaturated fatty acids (PUFAs) may be beneficial in a range of psychiatric conditions, including schizophrenia. Given that omega-3 PUFAs are generally beneficial to health and without clinically relevant adverse effects, their preventive use in psychosis merits investigation.

OBJECTIVE:

To determine whether omega-3 PUFAs reduce the rate of progression to first-episode psychotic disorder in adolescents and young adults aged 13 to 25 years with subthreshold psychosis.

DESIGN:

Randomized, double-blind, placebo-controlled trial conducted between 2004 and 2007.

SETTING:

Psychosis detection unit of a large public hospital in Vienna, Austria.

PARTICIPANTS:

Eighty-one individuals at ultra-high risk of psychotic disorder.

INTERVENTIONS:

A 12-week intervention period of 1.2-g/d omega-3 PUFA or placebo was followed by a 40-week monitoring period; the total study period was 12 months.

MAIN OUTCOME MEASURES:

The primary outcome measure was transition to psychotic disorder. Secondary outcomes included symptomatic and functional changes. The ratio of omega-6 to omega-3 fatty acids in erythrocytes was used to index pretreatment vs posttreatment fatty acid composition.

RESULTS:

Seventy-six of 81 participants (93.8%) completed the intervention. By study’s end (12 months), 2 of 41 individuals (4.9%) in the omega-3 group and 11 of 40 (27.5%) in the placebo group had transitioned to psychotic disorder (P = .007). The difference between the groups in the cumulative risk of progression to full-threshold psychosis was 22.6% (95% confidence interval, 4.8-40.4). omega-3 Polyunsaturated fatty acids also significantly reduced positive symptoms (P = .01), negative symptoms (P = .02), and general symptoms (P = .01) and improved functioning (P = .002) compared with placebo. The incidence of adverse effects did not differ between the treatment groups.

CONCLUSIONS:

Long-chain omega-3 PUFAs reduce the risk of progression to psychotic disorder and may offer a safe and efficacious strategy for indicated prevention in young people with subthreshold psychotic states. Trial Registration clinicaltrials.gov Identifier: NCT00396643.age 13-25 years

Omega-3 Fatty Acid Supplementation for the Treatment of Children With Attention-Deficit/Hyperactivity Disorder Symptomatology

Wednesday, February 1st, 2012

Omega-3 Fatty Acid Supplementation for the Treatment of Children With Attention-Deficit/Hyperactivity Disorder Symptomatology: Systematic Review and Meta-Analysis

Bloch MH, Qawasmi A (2011) Journal of the American Academy of Child & Adolescent Psychiatry 16 August EPub ahead of print

Several studies have demonstrated differences in omega-3 fatty acid composition in plasma and in erythrocyte membranes in patients with attention-deficit/hyperactivity disorder (ADHD) compared with unaffected controls. Omega-3 fatty acids have anti-inflammatory properties and can alter central nervous system cell membrane fluidity and phospholipid composition. Cell membrane fluidity can alter serotonin and dopamine neurotransmission. The goal of this meta-analysis was to examine the efficacy of omega-3 fatty acid supplementation in children with ADHD.

Method

PubMed was searched for randomized placebo-controlled trials examining omega-3 fatty acid supplementation in children with ADHD symptomatology. The primary outcome measurement was standardized mean difference in rating scales of ADHD severity. Secondary analyses were conducted to determine the effects of dosing of different omega-3 fatty acids in supplements.

Results

Ten trials involving 699 children were included in this meta-analysis. Omega-3 fatty acid supplementation demonstrated a small but significant effect in improving ADHD symptoms. Eicosapentaenoic acid dose within supplements was significantly correlated with supplement efficacy. No evidence of publication bias or heterogeneity between trials was found.

Conclusion

Omega-3 fatty acid supplementation, particularly with higher doses of eicosapentaenoic acid, was moderately effective in the treatment of ADHD. The relative efficacy of omega-3 fatty acid supplementation was modest compared with currently available pharmacotherapies for ADHD such as psychostimulants, atomoxetine, or α2 agonists. However, given its relatively benign side-effect profile and evidence of modest efficacy, it may be reasonable to use omega-3 fatty supplementation to augment traditional pharmacologic interventions or for families who decline other psychopharmacologic options.

These findings confirm that dietary supplementation with omega-3 high in EPA from fish oils can help to reduce symptoms of ‘ADHD’ in children – i.e. inattention, hyperactivity and impulsivity.

Importantly, they show that the benefits do not depend on a ‘clinical diagnosis’ of ADHD, as many of the trials included in this meta-analysis involved children recruited from non-clinical populations, and/or selected for other conditions such as dyslexia or dyspraxia.

The findings also indicate that of the two main long-chain omega-3 fatty acids in fish oils, EPA rather than DHA may be more effective for these purposes, although further studies would be needed to confirm this.  A similar advantage of EPA over DHA has also been noted in studies of omega-3 for depression. (see Martins et al 2009)

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