Archive for March, 2011

Omega 3 fish oil benefits may prevent Diabetic retinopathy

Thursday, March 31st, 2011

RESEARCH ARTICLE
ANTI-ANGIOGENESIS
5-Lipoxygenase Metabolite 4-HDHA Is a Mediator of the Antiangiogenic Effect of ω-3 Polyunsaturated Fatty Acids
Przemyslaw Sapieha1,2,*, Andreas Stahl1,3,*, Jing Chen1, Molly R. Seaward1, Keirnan L. Willett1, Nathan M. Krah1, Roberta J. Dennison1, Kip M. Connor1,†, Christopher M. Aderman1, Elvira Liclican4, Arianna Carughi5,6, Dalia Perelman5,6, Yoshihide Kanaoka7, John Paul SanGiovanni8, Karsten Gronert4 and Lois E. H. Smith1,‡
+ Author Affiliations

1Department of Ophthalmology, Harvard Medical School, Children’s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA.
2Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada H1T 2M4.
3University Eye Hospital Freiburg, Killianstrasse 5, Freiburg 79106, Germany.
4Vision Science Program, School of Optometry, University of California, Berkeley, CA 94720, USA.
5Health Research and Studies Center, Los Altos, CA 94022, USA.
6Palo Alto Medical Foundation, Palo Alto, CA 94301, USA.
7Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA.
8Division of Epidemiology and Clinical Research, National Eye Institute, Bethesda, MD 20892, USA
‡To whom correspondence should be addressed. E-mail: lois.smith@childrens.harvard.edu
ABSTRACT

Lipid signaling is dysregulated in many diseases with vascular pathology, including cancer, diabetic retinopathy, retinopathy of prematurity, and age-related macular degeneration. We have previously demonstrated that diets enriched in ω-3 polyunsaturated fatty acids (PUFAs) effectively reduce pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy, in part through metabolic products that suppress microglial-derived tumor necrosis factor–α. To better understand the protective effects of ω-3 PUFAs, we examined the relative importance of major lipid metabolic pathways and their products in contributing to this effect. ω-3 PUFA diets were fed to four lines of mice deficient in each key lipid-processing enzyme (cyclooxygenase 1 or 2, or lipoxygenase 5 or 12/15), retinopathy was induced by oxygen exposure; only loss of 5-lipoxygenase (5-LOX) abrogated the protection against retinopathy of dietary ω-3 PUFAs. This protective effect was due to 5-LOX oxidation of the ω-3 PUFA lipid docosahexaenoic acid to 4-hydroxy-docosahexaenoic acid (4-HDHA). 4-HDHA directly inhibited endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator–activated receptor γ (PPARγ), independent of 4-HDHA’s anti-inflammatory effects. Our study suggests that ω-3 PUFAs may be profitably used as an alternative or supplement to current anti–vascular endothelial growth factor (VEGF) treatment for proliferative retinopathy and points to the therapeutic potential of ω-3 PUFAs and metabolites in other diseases of vasoproliferation. It also suggests that cyclooxygenase inhibitors such as aspirin and ibuprofen (but not lipoxygenase inhibitors such as zileuton) might be used without losing the beneficial effect of dietary ω-3 PUFA.

↵* These authors contributed equally to this work.
↵† Present address: Massachusetts Eye and Ear Infirmary, Angiogenesis Laboratory, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.
Citation: P. Sapieha, A. Stahl, J. Chen, M. R. Seaward, K. L. Willett, N. M. Krah, R. J. Dennison, K. M. Connor, C. M. Aderman, E. Liclican, A. Carughi, D. Perelman, Y. Kanaoka, J. P. SanGiovanni, K. Gronert, L. E. H. Smith, 5-Lipoxygenase Metabolite 4-HDHA Is a Mediator of the Antiangiogenic Effect of ω-3 Polyunsaturated Fatty Acids. Sci. Transl. Med. 3, 69ra12 (2011).

Omega3 EPA breakthrough fish oil benefits bowel cancer treatment and prevention

Thursday, March 31st, 2011

In todays Daily Mail an article has stated that more than three quarters of women are living in ignorance of bowel cancer , a cancer that is more prevelant than both ovarian and cervical cancer put together, The study below gives a clear indication that Omega 3 EPA may indeed be a breakthrough treatment , they recommend 2 per day of EPA , TakeOmega3 is a highly purified form of omega3 which has 750 mg EPA per capsule so the patient would be required to take between 2-3 capsules per day of this product .

Diabetes: People with diabetes have a 30% to 40% increased chance of getting colorectal cancer. They also tend to have a higher death rate from this cancer.

A purified form of omega 3 EPA cuts the number and size of precancerous bowel growths (polyps) in people whose genetic make-up predisposes them to bowel cancer, finds research published ahead of print in the journal Gut. Furthermore, this particular omega 3 (eicosapentaenoic acid or EPA) seems to be as effective as the prescription medicine used to treat familial bowel polyps, but without the associated cardiovascular side effects.
The researchers base their findings on 55 patients, all of whom had the inherited genetic mutation that prompts the development of precancerous polyps in the bowel — known as familial adenomatous polyposis, or FAP for short.
People with FAP are at significantly increased risk of developing bowel cancer and require surgery to remove large sections of their bowel. Subsequently, some also need regular monitoring. All 55 patients had previously undergone surgery and were being monitored by endoscopy — a procedure involving a camera on the end of a flexible tube passed through the rectum.
Twenty eight of the patients were randomly assigned to six months of treatment with 2 g daily of a new highly purified form of the omega 3 polyunsaturated fatty acid (PUFA) EPA. The other 27 were given the same amount of a dummy treatment (placebo).
. Dietary omega 3 PUFA mainly comes from oily fish, such as salmon, mackerel, and herring.
An assessment of the number and size of polyps at the beginning and end of the six month study period revealed significant differences between the two groups of patients. The number of polyps increased by almost 10% among those treated with the placebo, but fell by more than 12% among those treated with the EPA capsules, representing a difference of almost 22.5%.
This was still clinically significant, even after taking account of influential factors, such as age and sex.
Similarly, polyp size increased by more than 17% among those in the placebo group but fell by more than 12.5% in those taking the EPA capsules, representing a difference of just under 30%.
The authors note that the effects of EPA were similar to those produced by celecoxib, which is used to help curb the growth of new and existing polyps in patients with FAP.
The use of celecoxib has been associated with harmful cardiovascular side effects in older patients. In this study, EPA produced few side effects and these were no more common than those produced by the placebo. This formulation of omega 3 might also help to prevent bowel cancer in people with the common non-familial form of bowel polyps, suggest the authors. As omega 3 PUFAs in general are safe and even good for cardiovascular health, Take Omega 3 EPA could be especially suitable for older patients at risk of both bowel cancer and heart disease, they say.

Prostate Cancer – Omega3 fish oil benefits offers protection against advanced prostate cancer

Wednesday, March 30th, 2011

In todays press Andrew Lloyd Webber has spoken about his battle with prostate cancer and the fact that it could return . Perhaps he should consider taking a high EPA omega3 product such as takeomega3 which may provide key protection against the cancer. EPA also acts in a similar way to viagra in that it dilates the blood vessels and provides better oxygen delivery

A diet high in omega-3 fatty acids offers protection against advanced prostate cancer, even in men who carry a particular variant in the COX-2 gene that is known to raise the risk of the disease.

“Previous research has shown protection (by omega-3 fatty acids) against prostate cancer, but this is one of the first studies to show protection against advanced prostate cancer and interaction with COX-2,” Dr. John S. Witte of the University of California, San Francisco noted in a statement from the American Association for Cancer Research.

Witte and colleagues studied 466 men diagnosed with aggressive prostate cancer and 478 healthy matched controls. They assessed diet using a “food frequency” questionnaire and genotyped the men for nine COX-2 variants.

The researchers report in the journal Clinical Cancer Research that increasing intake of long-chain omega-3 fatty acids — the kind found in dark fish, like salmon, and shellfish — was strongly associated with a decreased risk of aggressive prostate cancer.

Men who consumed the most long-chain omega-3 fatty acids had a 63 percent reduced risk of aggressive prostate cancer compared to men who consumed the least.

“Importantly,” Witte and colleagues say, this protective effect was even stronger in men who carried the COX-2 variant, rs4647310, which is a risk factor for prostate cancer.

Specifically, men with low intake of long-chain omega-3 fatty acids and this particular variant had a more than fivefold increased risk of advanced prostate cancer. But men with high intake of omega-3 fatty acids had a substantially reduced risk, even if they carried the COX-2 rs4647310 variant.

In other words, the increased risk of prostate cancer associated with the COX-2 rs4647310 variant was “essentially reversed by increasing omega-3 fatty acid intake by a half a gram per day,” Witte said.

Omega 3 and Prostate Cancer

Wednesday, March 30th, 2011

A diet high in omega-3 fatty acids offers protection against advanced prostate cancer, even in men who carry a particular variant in the COX-2 gene that is known to raise the risk of the disease.

“Previous research has shown protection (by omega-3 fatty acids) against prostate cancer, but this is one of the first studies to show protection against advanced prostate cancer and interaction with COX-2,” Dr. John S. Witte of the University of California, San Francisco noted in a statement from the American Association for Cancer Research.

Witte and colleagues studied 466 men diagnosed with aggressive prostate cancer and 478 healthy matched controls. They assessed diet using a “food frequency” questionnaire and genotyped the men for nine COX-2 variants.

The researchers report in the journal Clinical Cancer Research that increasing intake of long-chain omega-3 fatty acids — the kind found in dark fish, like salmon, and shellfish — was strongly associated with a decreased risk of aggressive prostate cancer.

Men who consumed the most long-chain omega-3 fatty acids had a 63 percent reduced risk of aggressive prostate cancer compared to men who consumed the least.

“Importantly,” Witte and colleagues say, this protective effect was even stronger in men who carried the COX-2 variant, rs4647310, which is a risk factor for prostate cancer.

Specifically, men with low intake of long-chain omega-3 fatty acids and this particular variant had a more than fivefold increased risk of advanced prostate cancer. But men with high intake of omega-3 fatty acids had a substantially reduced risk, even if they carried the COX-2 rs4647310 variant.

In other words, the increased risk of prostate cancer associated with the COX-2 rs4647310 variant was “essentially reversed by increasing omega-3 fatty acid intake by a half a gram per day,” Witte said.

Taking Omega 3 fish oil benefits may prevent Secondary cardiovascular disease

Saturday, March 26th, 2011

Secondary cardiovascular disease prevention (fish oil / EPA plus DHA)
Several well-conducted randomized controlled trials report that in people with a history of heart attack, regular consumption of oily fish or fish oil/omega-3 supplements reduces the risk of non-fatal heart attack, fatal heart attack, sudden death, and all-cause mortality (death due to any cause). Most patients in these studies were also using conventional heart drugs, suggesting that the benefits of fish oils may add to the effects of other therapies.

Omega 3 offers Protection from cyclosporine toxicity in organ transplant patients

Saturday, March 26th, 2011

Protection from cyclosporine toxicity in organ transplant patients
There are multiple studies of heart transplant and kidney transplant patients taking cyclosporine (Neoral®), who were administered fish oil supplements. The majority of trials report improvements in kidney function, and less high blood pressure compared to patients not taking fish oil the weight of scientific evidence favors the beneficial effects of fish oil.

Omega 3 EPA fish oil benefits helps prevent obesity related diseases such as diabetes and heart disease

Friday, March 25th, 2011

A new study has suggested that a high intake of omega-3 fats found in fish helps prevent obesity-related chronic diseases such as diabetes and heart disease. Fish oil benefits .

The scientists come to the conclusion after studying Yup’ik Eskimos in Alaska, who on average consume 20 times more omega-3 fats from fish than people in the lower 48 states.

Researchers at Fred Hutchinson Cancer Research Center in collaboration conducted the study with the Center for Alaska Native Health Research at the University of Alaska-Fairbanks.

The fats the researchers were interested in measuring were those found in salmon, sardines and other fatty fish: docosahexaenoic acid, or DHA, and eicosapentaenoic acid, or EPA.

Researchers analyzed data from a community-based study of 330 people living in the Yukon Kuskokwim Delta region of southwest Alaska, 70 percent of whom were overweight or obese.

As expected, the researchers found that in participants with low blood levels of DHA and EPA, obesity strongly increased both blood triglycerides (a blood lipid abnormality) and C-reactive protein, or CRP (a measure of overall body inflammation).

Elevated levels of triglycerides and CRP increase the risk of heart disease and, possibly, diabetes.

“These results mimic those found in populations living in the Lower 48 who have similarly low blood levels of EPA and DHA,” said senior author Alan Kristal.

“However, the new finding was that obesity did not increase these risk factors among study participants with high blood levels of omega-3 fats, he said.

Lead author Zeina Makhoul said, “Interestingly, we found that obese persons with high blood levels of omega-3 fats had triglyceride and CRP concentrations that did not differ from those of normal-weight persons.

“It appeared that high intakes of omega-3-rich seafood protected Yup’ik Eskios from some of the harmful effects of obesity,” Makhoul added.

The study was published online March 23 in the European Journal of Clinical Nutrition. (ANI)

Omega3 a key anti inflammatory

Tuesday, March 22nd, 2011

Inflammation is a natural reaction by the body to allow itself to repair and is infact a key defense mechanism. It is a reaction to a number of factors such as injury , infection , allergens and chronic disease.
The body when it is under attack by one or more of these factors creates a cellular reaction – the cells effectively upregulate production of numerous molecules and as a result there is redness, swelling and pain in the tissue involved. When this happens immune cells go to the site of the inflammation where they help to destroy and get rid of the offending stimuli.
The acute inflammatory response is usually self limiting and an integral part of the healing process . However if this does get out of control the inflammation can damage tissues and hinder the body’s repair mechanisms and as a result chronic disease can be the result such as osteoarthritis , rheumatoid arthritis, . Chronic inflammation is implicated in a large number of systemic disorders including hearrt disease, type 2 diabetes, hypertension , diabetes mellitus, metabolic syndrome, neurodegeneration . It is therefore essential for good health to maintain a properly modulated metabolic pathway as it is the metabolic pathways that lead to overproduction of inflammatory mediators.
Conventional treatment of pro inflammatory conditions and diseases typically involves the use of non steroidal anti inflammatory drugs – however these are not always effective and can have serious implications on gastrointestinal , renal , cardio health with regards the side effects. As a result of this research is ongoing looking at more natural ways to treat inflammation – one of the most consistent performers in this is omega3 specifically EPA which has been shown to have perhaps the most powerful ability to modulate key inflammatory mediators such as COX-2.

Omega 3 Fish Oil and Depression , Mental Health as used in NHS

Monday, March 21st, 2011

Recent studies have shown that 1000mg EPA  omega 3 fish oil is as effective as Prozac in the treatment of medium to severe depression . When used together with the anti depressant it was even more effective than either treatment separately .
Forth Valley HealthBoard  recommend the brand takeomega 3  fish oil both as an adjunctive and primary therapy in medium to severe depression as well as other mental health disorders such as PTSD, OCD .
The reason they use and recommend Takeomega 3 fish oil  is primarily due to the fact this is the highest concentration currently available at just under 90% it also offers 750mg EPA per capsule with minimal quantities of DHA . The product is also manufactured in MHRA licensed facilities .

Forth Valley HealthBoard  Omega 3 Fish Oil Depression

Nutrition in Cancer and the benefits of Omega 3 Take Omega3

Monday, March 21st, 2011

Recent study has shown that Omega3 specifically EPA may have a unique role in the prevention of weightloss muscle loss often associated when undergoing Chemotherapy. To date there has been no solution to this however this recent study shows the importance omega3
supplementation may play in those people undergoing treatment .TakeOmega 3 high EPA supplements may help chemotherapy patients
Omega-3 fish oil supplements high in EPA may help cancer patients to prevent the muscle loss and malnutrition which commonly accompanies chemotherapy, according to new research.

EPA rich omega-3 supplements may help chemotherapy patients, say researchers.

The study, published in Cancer found that patients supplemented with 2.2 grams of eicosapentaenoic acid per day maintained weight, muscle mass, and adipose tissue throughout approximately 10 weeks of chemotherapy despite having a mean weight loss of 6.3 percent over the previous 6 months.

In the same time, patients receiving standard treatment with no supplementation were found to loose an average of 2.3 kilograms.

“Fish oil may prevent loss of weight and muscle by interfering with some of the pathways that are altered in advanced cancer … This holds great promise because currently there is no effective treatment for cancer-related malnutrition,” said Dr. Vera Mazurak, from the University of Alberta, Canada, who led the study.

The researchers said that a nutritional intervention with two grams of fish oil (in the form of EPA) per day may provide a benefit over standard care, by allowing cancer patients to maintain weight and muscle mass during chemotherapy.

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