Archive for 2010

Omega 3 stronger than any other anti inflammatory

Wednesday, December 15th, 2010

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects”

Omega-3s may reduce inflammation by acting on a receptor found in fat tissue and on inflammatory immune cells called macrophages, according to research.

The new research published in the journal Cell, suggests the mechanisms behind omega-3’s actions as an anti-inflammatory are due to its action on G-protein-coupled receptor 120 (GPR120) working as an omega-3  FA receptor/sensor.

“Omega-3s are very potent activators of GPR120 on macrophages – more potent than any other anti-inflammatory we’ve ever seen,” said lead researcher Dr Jerrold Olefsky of the University of California, San Diego.

Anti-inflammatory

Omega-3 fatty acids have been long associated with anti-inflammatory effects; however the mechanisms behind such effects have been poorly understood.

GPR120 is a G protein-coupled receptor (GPCRs) – part of a group involved in many important cell functions, and is the target of many drugs.

Previous research has suggested that five GPCRs – including GPR120 included – respond well respond to free fatty acids.

Since chronic tissue inflammation is linked to insulin resistance in obesity, the researchers used GPR120 knock-out mice to investigate if omega-3 leads to GPR120-mediated anti-inflammatory and insulin sensitizing effects in vivo.

Robust effect

Researchers found that GPR120 functions as an omega-3 receptor in pro-inflammatory macrophages and mature adipocytes.

When knock-out mice were fed a high-fat diet and treated with omega-3 fatty acids, they showed all the signs of inflammation and the insulin resistance that leads to diabetes with omega-3 having no effect.

Normal mice on a high-fat diet still gained weight, however, omega-3s “had a really robust effect in preventing inflammation,” Olefsky said.

The study also observed that by signalling through GPR120, omega-3 fatty acids mediate potent anti-inflammatory effects to inhibit certain key inflammatory signaling pathways.

The study reports that omega-3 treatment was as effective – or in some cases more effective – than the popular insulin-sensitizing drug Rosiglitazone.

The researchers noted that activation of GPR120 by omega-3s blocks not one, but all inflammatory pathways.

Interpretation

Olefsky said his team focused on GPR120 from the beginning because of where it is found – in fat tissue and on macrophages. Olefsky noted that if your goal is to fight inflammation then “that’s just where you’d want them to be expressed.”

How these findings can be interpreted for humans is not yet clear, but with a growing trend in omega-3 supplementation and increased dietary intakes of omega-3 a goal for many consumers.

Olefski says it is too early to make any formal reccomendations at the moment, but highlights that he does not see any problem with people taking omega-3 supplementations “as long as it isn’t in enormous doses.”

Olefski said that further research needs to be conducted into several – currently unknown – omega-3 mechanisms. For one, omega-3s seems to block the migration of macrophage cells into tissues – “It’s a remarkable effect, and we don’t know its action,” he added.

Source: Cell

Vol 142(5) pp. 687 – 698, doi: 10.1016/j.cell.2010.07.041

“GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects”


Omega 3 EPA reduces LDL cholesterol levels – TakeOmega3 has 750mg EPA per capsule

Wednesday, December 15th, 2010

New clinical study results presented at the American Heart Association Scientific Sessions show that the long-chain omega-3 fatty acid EPA (eicosapentaenoic acid), helped significantly reduce small dense LDL (bad) cholesterol levels.

“This study suggests that supplementation with the omega-3 fatty acid EPA may present unique benefits for cardiovascular health,” said Sujata K. Bhatia, M.D., Ph.D., research associate with DuPont. “EPA was shown to have advantageous effects on several biomarkers, including LDL cholesterol, small dense LDL, and lp-PLA2.”

EPA is a long-chain fatty acid that is found primarily in cold water, fatty fish like sardines anchovies mackerel  as well as some omega-3 fatty acid such as TakeOmega3 which has 750 mg EPA per capsule  and is the highest grade omega 3 available in UK . A growing body of evidence suggests that EPA is the long-chain omega-3 that supports heart health.

The study, conducted by Cardiovascular Research Associates and sponsored by DuPont, was conducted among 110 healthy individuals comparing the effects of EPA supplements to DHA (docosahexaenoic acid) supplements on cardiovascular health. The participants were placed into four study groups and examined over a six week period. During that time, each group was monitored while taking: EPA 600 mg per day; EPA 1,800 mg per day; DHA 600 mg per day; and an olive oil placebo.

The study found that in the 1,800mg EPA group, there were significant reductions of 7 percent for small dense low density lipoprotein (LDL) cholesterol, and 6 percent for lipoprotein-associated phospholipase A2 (lp-PLA2). lp-PLA2 is an enzyme involved in vascular inflammation.
In contrast, the 600mg DHA group showed a significant increase in total small dense LDL cholesterol in both the fasting and fed state of 14.2 percent and 16.3 percent respectively.

The study results will be featured during the American Heart Association Conference poster session in Chicago

Treatment of depression with omega3 – encouraging results from largest clinical study

Monday, November 15th, 2010

The study was published in the online Journal of Clinical Psychiatry.This was the largest study ever conducted assessing Omega-3’s efficacy in treating major depression. It was carried out in conjunction with researchers from centres affiliated with the UdM’s Réseau universitaire intégré de santé (RUIS), from McGill University, Université Laval in Quebec City and Queen’s University in Kingston, Ontario. The study was supported by the European the Fondation du CHUM and the CRCHUM.

Initial analyses failed to clearly demonstrate the effectiveness of Omega-3 for all patients taking part in the study. Other analyses, however, revealed that Omega-3 improved depression symptoms in patients diagnosed with depression unaccompanied by an anxiety disorder. Efficacy for these patients was comparable to that generally observed with conventional antidepressant treatment.From October 2005 to January 2009, 432 male and female participants with major unipolar depression were recruited to take part in this randomized, double-blind study (neither patients nor researchers knew which capsules patients received). For eight weeks, half of the participants took three capsules per day of a fish oil supplement containing high concentrations of eicosapentaenoic acid (EPA). The other half took three identical capsules of a placebo consisting of sunflower oil, flavoured with a small quantity of fish oil. In contrast with typical clinical studies designed to assess the effectiveness of antidepressants, this study included a high proportion of patients with complex and difficult-to-treat conditions, including patients resistant to conventional antidepressant treatments and patients also suffering from an anxiety disorder. The aim was to assess the value of Omega-3 supplementation in a group of individuals more like those treated in outpatient clinics.Some 11% of men and 16% of women in Canada will suffer from major depression at some point in their lives, making this disorder one of our society’s leading public health issues. Depression, which is now the world’s fourth leading cause of morbidity and death is expected to move up to the number two position by 2020. “Despite significant progress in neuroscience over the past two decades, depression is difficult to treat,” Dr. Lespérance noted. In view of the large number of patients who stop taking their medications in the first few months of treatment and those who refuse such treatment due to fear of stigmatization or side effects, it comes as no surprise that a large number of patients suffering from major depression use alternative treatments offered outside the healthcare system. “Many of these treatments have not been adequately evaluated. That is why it was important to assess the efficacy of Omega-3, one of the most popular alternative approaches,” he added.It is important to note that the study assessed use of Omega-3 for eight weeks, at doses of 1050 mg of EPA and 150 mg of DHA each day. It is currently unknown whether taking higher doses or taking supplements over a longer period would yield different results.

Omega 3 fish oil health benefits for depression , heart health , arthritis

Monday, November 15th, 2010

Omega 3 fish oil health benefits for depression , heart health , arthritis

Omega-3 fatty acids are considered essential fatty acids: They are necessary for human health but the body can’ t make them therefore you have to get them through food. The best sources of Omega-3 fatty acids or PUFA’s (poly unsaturated fatty acids ) are be found in oily fish, such as sardines, anchovies salmon, tuna, and halibut, it is also found in smaller amounts in some plants, and nuts such as walnuts . A lot of people nowadays choose to take a good quality supplement such as Take Omega 3 which is an 85% high grade omega 3 with 750 mg EPA and 50 mg DHA per capsule one capsule per day ensures you will maintain your levels of omega3 and as a result enjoy better health . Omega-3 fatty acids play a crucial role in brain function as well as growth and development and helps protect the immune system. In recent years omega3 became popular because they may reduce the risk of heart disease and we are now seeing the pharmaceutical companies developing new drugs for heart disease which are highly concentrated forms of omega 3 specifically EPA The American Heart Association recommends eating oily fish at least 2 times a week. For those of you who dont like oily fish taking a one per day high EPA supplement such as take omega 3 which will supply your requirements and it can be taken at any time of the day with or without food .

What does scientific research say about omega3 ? Research shows that omega-3 fatty acids reduce inflammation and may help lower risk of chronic diseases such as heart disease, cancer, and arthritis. Omega-3 fatty acids are highly concentrated in the brain and appear to be important for cognitive (brain memory and performance) and behavioral function. In fact, infants who do not get enough omega-3 fatty acids from their mothers during pregnancy are at risk for developing vision and nerve problems. Symptoms of omega-3 fatty acid deficiency include fatigue, poor memory, dry skin, heart problems, mood swings or depression, and poor circulation.

In fact most people in western world will have low levels of omega 3 and high levels of omega 6 mainly down to the fact we dont eat oily fish and we more and more use convenience foods , it can be easily addressed by taking 1 capsule of take omega3 per day within 6 weeks your omega 3 levels will have built up in your system and you should start to feel and see the benefits .

If you would like to see full studies relating to the various medical conditions please contact us . The strongest scientific evidence with regards omega 3 is clearly for heart disease and the various medical conditions that are associated with heart disease. However more and more studies are now looking at the benefits of omega3 with regards depression and the key appears to be to have a high EPA formulation such as takeomega3 . EPA is a key anti inflammatory therefore it is used as an adjunctive therapy in conditions such as rheumatoid arthritis and osteo arthritis. With regards depression there has been success in using high EPA in the treatment of medium to severe depression both as an adjunctive therapy and as a stand alone treatment where it was found to be as effective as prozac – infact several clinics both NHS and private specialising in the treatment of mental health disorders use TakeOmega3 specifically for this purpose due to it being one of the highest concentrations available at 85% with 750 mg EPA and 50 mg DHA.

Do your omega3 capsules come from China ?

Monday, November 8th, 2010

We are proud to say that the oil we use in our takeomega3 fish oil does not and we are very open about the fact that our oil is sourced directly from Peru and then purified in an MHRA approved facility in the UK . However it is not that easy to determine where fish oil is sourced – a recent report has found the following with regards the australian market We calculate that fish oil imports from China, a country notorious for hazardous products, now account for roughly 10 percent of the Australian market. And it’s a big market, because one in five Australian adults now takes fish oil.We also found that companies sidestep import labeling rules.

No big recalls or health scandals have been linked to Chinese fish oil. And a spokesman for the People’s Republic of China said his country’s “fish oil was of good quality”.

But consumer advocates, a leading trade group for the supplements industry, and legal experts who have examined labeling laws agree: Consumers ought to be able to tell, at a glance, whether their fish oil capsules are coming from China.

Leo Hepner, an international consultant on food and dietary supplement ingredients, said that if he knew some fish oil capsules were manufactured in China, “I would prefer to buy something else.”

And Sidney Wolfe, whose Public Citizen Health Research Group has advocated for consumer safety for decades, said, “People have a right to know.”

Some Australian companies are buying the Chinese fish oil in bulk and then getting the capsules produced by an Australian contract manufacturer.

The Chinese factories that make fish oil for export to the Australia are supposed to meet TGA standards. But the TGA, according to several sources, has never inspected any Chinese dietary supplement plants.

Chinese companies also have shown little interest in having independent third parties inspect their plants or in joining industry groups dedicated to ensuring the quality of fish oil.

One such group is GOED — the Global Organization for EPA and DHA Omega 3s says “There’s not a single Chinese manufacturer in GOED,”. “You tell me why.”

Careful processing of fish oil is important to keep it from becoming rancid. Without proper refining it can contain high levels of some nasty substances, such as PCBs and mercury.

In addition, lightly regulated plants introduce the possibility of products’ containing odd contaminants or additives that no one would think to test for.

Does Omega 3 have benefits for male fertility ?

Tuesday, November 2nd, 2010

Men who eat a lot of saturated fat could be damaging their sperm, new research suggests.

Experts at Harvard Medical School in the US found men who consume lots of saturated fat and monounsaturated fat may have fewer sperm.

In contrast, those who eat healthier fats – specifically omega 3 and omega 6 – may have healthier sperm that is more active, the study suggests.

Saturated fat is found in processed meats such as bacon, sausages and ham, dairy and butter. Monounsaturated fat is found in items such as olive oil.

Researcher Dr Jill Attaman, said: “We were able to demonstrate that in men who took in higher amounts of fats, such as saturated fat and monounsaturated fat, there was an association with decreased sperm concentration.

“But polyunsaturated fat – those seen in fish primarily – was associated with improved sperm morphology and motility.”

Morphology relates to the size and shape of the sperm and is an indicator of fertility.

The research was carried out on 91 men seeking fertility treatment but Dr Attaman said she would expect to see a “similar pattern” in the general population, although this would need to be studied.

The men were asked how often they ate certain foods, what types of oil they used in cooking and baking and the types of margarine they consumed.

Of the group, 21 men also had levels of fatty acids in their sperm and semen measured.

Overall, those men in the highest saturated fat intake group took in 13% of their daily calories as saturated fat, while those in the lowest third took in 8%.

The study concluded: “Men in the highest third of saturated fat intake had 41% fewer sperm than those in the lowest third.

“Likewise men in the highest third of monounsaturated fat intake had 46% fewer sperm than those in the lowest third.”

Asked if the findings suggested a potentially large impact on a man’s ability to father a child, Dr Attaman said it depended on the men.

Those with a borderline level of sperm concentration might see more of an effect than those who already had a healthy number of sperm, she said.

She added that the exact reasons for the apparent connection are unclear and require more work.

But “dietary modifications could be beneficial for global health as well as reproductive health,” she said.

The findings were presented at the American Society for Reproductive Medicine conference in Denver.

Dr Tony Rutherford, chair of the British Fertility Society, said the study was small but the conclusion was that people should eat a healthy, balanced diet.

Can omega3 help with depression ?

Wednesday, October 20th, 2010

TakeOmega3 is a unique 85% omega3 formulation with each capsule containing 750mg EPA and 50mg DHA , it is also uniquely manufactured in the UK in a MHRA approved facility  this is the reason is it used by leading Psychiatrists , Hospitals and Clinics either as an adjunctive therapy for the treatment of depression or as primary treatment.So why  take omega3 for the treatment of depression and how does it work ? Unlike products such as St Johns Wort Take Omega3 is completely safe to take alongside other medication .

EPA  helps to block the action of the P-glycoprotein pump (Pgp) located near the blood/brain barrier. Many antidepressants, including the most selective serotonin re-uptake inhibitors (SSRIs), are barred from entering the brain by Pgp. Hence, EPA promotes the absorption of some antidepressants in the brain, an ideal tool to tackle therapy resistant depression. (Murck H et al., 2004) It is not surprising that Omega 3  has a significant impact on brain activity: 60% of our dry brain matter consists of fats. The production, breakdown, release, re-absorption and binding of neurotransmitters can be influenced by the fatty acids nestling in the cell membranes of nerve cells. In fact it is now known that the consumption of fish oil has a beneficial effect on serotonin control EPA supplementation, in both unipolar and bipolar depression has been used with conventional medication such as paroxetine, fluoxetine, mirtazapine, fluvoxamine, moclobemide, citalopram, trazodone, lithium, valproate, carbamazepine, clonazepam and venlafaxine.

Omega 3 and Kidney Cancer

Wednesday, October 13th, 2010

In 2006 there was a study published which looked at the consumption of oily fish which is high in omega3 and the rate of Kidney Cancer – over a period of 15 years they looked at the how it compared to consumers of lean fish ie cod .What they found was quite dramatic those who ate oily fish which is high in omega3 specifically EPA had a 74% lower risk of developing kidney cancer in comparison to those who ate no fish at all .Those who ate the lean fish ie cod did not get the same results as those eating the oily fish. Not everyone likes to eat oily fish which is why more and more people are choosing to take omega 3 in the form of a supplement – however not all supplements are equal. TakeOmega3 is an 85% clinical grade omega3 which has the highest concentrations of omega3 currently available. Each capsule contains 750mg EPA and 50mg DHA .
The researchers, writing in the Journal of the American Medical Association, did not indicate whether fatty fish might prevent other types of cancer.
Of more than 61,000 women in the study, ranging in age from 40 to 76, 150 developed kidney cancer.
In the United States, there is a one in 77 lifetime risk of kidney cancer, and 39,000 Americans expected to be diagnosed this year, according to the American Cancer Society. The disease is twice as common among men than women.
With regards Prostate Cancer previous studies have found eating fatty fish such as sardines anchovies, salmon herring, and mackerel could reduce men’s risk of developing prostate cancer. Essential fatty acids – especially omega-3 fatty acids contained in large amounts in fatty fish – have previously been proved to inhibit the growth of prostate cancer cells.

High intake of omega 3 may significantly reduce risk of chronic disease

Friday, September 17th, 2010

Intakes of omega-3 exceeding levels consumed by the general US population may significantly reduce the risk of chronic disease, suggests a new study with Yup’ik Eskimos.

High levels of the omega-3 fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) were associated with lower levels of triglycerides, as well as higher levels of HDL cholesterol, according to data from 357 Yup’ik Eskimos published in the American Journal of Clinical Nutrition.

Raised levels of the fatty acids were also associated with decreased levels of markers of inflammation, such as C-reactive protein (CRP), which is produced in the liver and is a known marker for inflammation. Increased levels of CRP are a good predictor for the onset of both type-2 diabetes and cardiovascular disease. CVD causes almost 50 per cent of deaths in Europe, and is reported to cost the EU economy an estimated €169 billion ($202 billion) per year.

The study of omega-3 intakes in inuits is nothing new. The first reports of the heart health benefits of the marine fatty acids were reported in the early 1970s by Jørn Dyerberg and his co-workers in The Lancet and The American Journal of Clinical Nutrition. The young Danes sought to understand how the Greenland Eskimos, or Inuit as they prefer to be called, could eat a high fat diet and still have one of the lowest death rates from cardiovascular disease on the planet.

Despite the precedent of study in these populations, the new research, led by Zeina Makhoul from Fred Hutchinson Cancer Research Center in Seattle, claims that: “Few studies have examined the associations of with biomarkers of chronic disease risk in populations with high intakes”.

In an attempt to fill this knowledge gap, they analysed blood levels of EPA and DHA in red blood cells of in a cross-section of 357 Yup’ik Eskimos.

Data showed EPA and DHA represented an average 2.8 and 6.8 percent, respectively, of the total fatty acid content of red blood cells.

In addition to the links between EPA and DHA levels and triglycerides and HDL, increased levels of DHA were positively with levels of LDL and total cholesterol, said the researchers.

While a link between EPA/DHA and CRP were reported, Makhoul and her co-workers noted that the link was stronger when EPA concentrations excessed 3 percent of fatty acids in the cells, and when DHA levels exceeded 7 percent.

“Increasing EPA and DHA intakes to amounts well above those consumed by the general US population may have strong beneficial effects on chronic disease risk,” they concluded.

Source: American Journal of Clinical Nutrition
Published online ahead of print, doi: 10.3945/ajcn.2009.28820
“Associations of very high intakes of eicosapentaenoic and docosahexaenoic acids with biomarkers of chronic disease risk among Yup’ik Eskimos”
Authros: Z. Makhoul, A.R. Kristal, R. Gulati, B. Luick, A. Bersamin, B. Boyer, G.V. Mohatt

Omega-3s anti-inflammatory mechanism revealed

Friday, September 17th, 2010

Take Omega 3  Mind Body Cardio formulation  has the highest concentrations of EPA per capsule than any other brand in UK , we are unique in that we contain 750mg EPA and are a 85% omega-3 concentrate – EPA is the key omega 3  for anti -inflammatory purposes .

Omega-3s may reduce inflammation by acting on a receptor found in fat tissue and on inflammatory immune cells called macrophages, according to research.

The new research published in the journal Cell, suggests the mechanisms behind omega-3’s actions as an anti-onflammatory are due to its action on G-protein-coupled receptor 120 (GPR120) working as an omega-3  FA receptor/sensor.

“Omega-3s are very potent activators of GPR120 on macrophages – more potent than any other anti-inflammatory we’ve ever seen,” said lead researcher Dr Jerrold Olefsky of the University of California, San Diego.

Anti-inflammatory

Omega-3 fatty acids have been long associated with anti-inflammatory effects; however the mechanisms behind such effects have been poorly understood.

GPR120 is a G protein-coupled receptor (GPCRs) – part of a group involved in many important cell functions, and is the target of many drugs.

Previous research has suggested that five GPCRs – including GPR120 included – respond well respond to free fatty acids.

Since chronic tissue inflammation is linked to insulin resistance in obesity, the researchers used GPR120 knock-out mice to investigate if omega-3 leads to GPR120-mediated anti-inflammatory and insulin sensitizing effects in vivo.

Robust effect

Researchers found that GPR120 functions as an omega-3 receptor in pro-inflammatory macrophages and mature adipocytes.

When knock-out mice were fed a high-fat diet and treated with omega-3 fatty acids, they showed all the signs of inflammation and the insulin resistance that leads to diabetes with omega-3 having no effect.

Normal mice on a high-fat diet still gained weight, however, omega-3s “had a really robust effect in preventing inflammation,” Olefsky said.

The study also observed that by signalling through GPR120, omega-3 fatty acids mediate potent anti-inflammatory effects to inhibit certain key inflammatory signaling pathways.

The study reports that omega-3 treatment was as effective – or in some cases more effective – than the popular insulin-sensitizing drug Rosiglitazone.

The researchers noted that activation of GPR120 by omega-3s blocks not one, but all inflammatory pathways.

Interpretation

Olefsky said his team focused on GPR120 from the beginning because of where it is found – in fat tissue and on macrophages. Olefsky noted that if your goal is to fight inflammation then “that’s just where you’d want them to be expressed.”

How these findings can be interpreted for humans is not yet clear, but with a growing trend in omega-3 supplementation and increased dietary intakes of omega-3 a goal for many consumers.

Olefski says it is too early to make any formal reccomendations at the moment, but highlights that he does not see any problem with people taking omega-3 supplementations “as long as it isn’t in enormous doses.”

Olefski said that further research needs to be conducted into several – currently unknown – omega-3 mechanisms. For one, omega-3s seems to block the migration of macrophage cells into tissues – “It’s a remarkable effect, and we don’t know its action,” he added.

The researchers also pointed out that whilst omega-3s appear to be very good at activating GPR120 to reduce inflammation, the fatty acid actually has a relatively low affinity for the receptor. Olefsky commented that it is possible other small molecules could be found to work even better than omega-3.

Source: Cell

Vol 142(5) pp. 687 – 698, doi: 10.1016/j.cell.2010.07.041

“GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects”

Authors: D.Y. Oh, S. Talukdar, E. J. Bae, T. Imamura, H. Morinaga, W.Q. Fan, P. Li, W.J. Lu, S.M. Watkins, J.M. Olefsky

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